In recent years, with the deepening integration of medicine and engineering and advances in thermometry and temperature-control technologies, whole-body hyperthermia (WBH) has attracted increasing attention. Unlike local hyperthermia, WBH elevates the temperature of the entire body, thereby not only subjecting the lesion site to heat stress but also fully mobilizing the host’s immune responses at multiple sites and through multiple pathways, thus broadly regulating body metabolism to exert therapeutic effects. With its unique advantages, WBH has become a frontier hotspot in hyperthermia research. To date, a growing body of basic and clinical evidence has confirmed the therapeutic potential and efficacy of WBH in the treatment of both oncologic and non-oncologic conditions. Against this background, the expert consensus focuses on summarizing key points including the definition and classification of WBH, its antitumor mechanisms, clinical implementation techniques, complications, and management principles, with the aim of providing guidance for the clinical application and promotion of WBH.

This study analyzes the textual characteristics of China's national-level dementia prevention and treatment policies during the "14th Five-Year Plan" period, reveals the distribution patterns and intrinsic relationships among policy instruments, stakeholders, and policy intensity, and provides a basis for optimizing and improving the policy system.

National-level policy texts related to dementia prevention and treatment issued from 2021 to 2025 were retrieved; a three-dimensional analytical framework comprising "policy tools-stakeholders-policy intensity" was constructed; content analysis was employed for coding; and coding reliability was tested using Cohen’s Kappa coefficient. MAXQDA 2022 was used to conduct quantitative statistical analysis across three dimensions: policy instrument types (supply-oriented, environment-oriented, and demand-oriented), stakeholders (six categories including government departments, medical institutions, and healthcare personnel), and policy intensity (1-5 points).

A total of 15 policy texts related to dementia prevention and treatment were included, yielding 276 policy instrument codes, with good coding reliability (the three-dimensional kappa coefficients are 0.85, 0.82, and 0.82, respectively). Unidimensional analysis showed that environmental-oriented tools have the highest proportion (122 codes, 44.20%), followed by supply-oriented tools (113 codes, 40.94%), and demand-oriented tools have a significantly lower proportion (41 codes, 14.86%); policy attention was focused on medical institutions (73 codes, 30.80%) and government departments (71 codes, 29.96%), while social capital (18 codes, 7.59%) and health personnel (16 codes, 6.75%) had lower levels of attention; the average policy intensity was relatively low (2.80 points), manifested by the coexistence of six joint documents issued by three or more ministries and five separate documents issued by each ministry, and the lack of policies issued by the dual ministries and commissions. Cross analysis showed that policy tools were unevenly distributed among different entities, with medical institutions (73 codes) and government departments (71 codes) undertaking the most, while health personnel (16 codes) and social capital (18 codes) undertaking the least; the average strength of the three types of tools was 2.55 points for demand type, 2.34 points for environmental type, and 2.20 points for supply type. The price service strength in the demand-oriented tools was the highest (4.50 points), but only 4 codes were available. In 3D analysis, environmental tools had the highest total strength (306 points), while demand based tools had the lowest (116 points); medical institutions (139 points) and government departments (122 points) ranked first in terms of overall strength, while health personnel had the lowest (30 points).

The policy system for the prevention and treatment of dementia in China presents structural characteristics of "intensive planning, supply start-up, insufficient demand and weak strength". The allocation of policy tools focuses more on supply, with insufficient attention to demand. The executing entities are concentrated in medical institutions and government departments, and the overall policy intensity is low and lacks continuity. Continuous optimization is needed in terms of tool balance, subject coverage, and intensity continuity.

To investigate the dynamic patterns of frailty among middle-aged and older adults and their associations with the risk of cardiovascular disease (CVD), and to further examine the mediating role of physical activity in this association.

Using data from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2018, all participants enrolled between 2011 and 2015 who were aged≥45 years, had fewer than 5 frailty index items, and without CVD were included. Frailty status was assessed using the Rockwood frailty index and a group-based trajectory model was employed to identify dynamic patterns of frailty change. The primary outcome was self-reported physician-diagnosed CVD at the 2018 follow-up, defined as heart disease or stroke. Cox proportional hazards models were used to assess the associations between frailty trajectories and incident CVD. Furthermore, inverse probability weighting-based marginal structural models were used to evaluate the mediating effect of physical activity on the association between frailty trajectories and CVD risk.

A total of 8,876 participants were included. From 2011 to 2018, transitions among robust, prefrail, and frail states showed substantial dynamism and reversibility. The optimal trajectory model identified three distinct frailty patterns (i.e., trajectory groups 1, 2, and 3), defined asa low-level stable group (n=6 094), a moderate-level increasing group (n=2 299), and a high-level increasing group (n=483). Significant differences were observed across the three trajectory groups in age, sex, educational level, marital status, body mass index, smoking, alcohol consumption, social activity, grip strength, 2.5-meter walk time, and chair stand performance (P < 0.01). Compared with the low-level stable group, the risk of incident CVD was significantly higher in the moderate-level increasing group (HR=2.15, 95%CI: 1.94-2.40, P < 0.01 ) and the high-level increasing group (HR=3.43, 95%CI: 2.92-4.04, P < 0.01), with CVD risk increasing progressively with higher frailty levels and greater frailty progression. Declines in physical activity mediated approximately 21%-23% of the association between frailty trajectories and incident CVD.

Dynamic trajectories of frailty among middle-aged and older adults were significantly associated with the risk of incident CVD, and part of this association was related to declines in physical activity. Among individuals with progressive frailty, maintaining or improving physical activity may help reduce the risk of cardiovascular disease.

To investigate the association between intrinsic capacity and COVID-19 infection as well as immunosenescence in community-dwelling older adults, and to provide evidence for precision health management in this population.

A total of 190 community-dwelling older adults who established health records at Zhejiang Hospital between January 2023 to December 2024 were enrolled as subjects. Data were collected using a general information questionnaire and the intrinsic capacity assessment scale for older adults. Peripheral blood lymphocyte subsets and other immune function parameters were measured. Latent profile model was employed to identify latent profiles of intrinsic capacity. Univariate analysis was performed to compare clinical and immunological characteristics across different profiles, and multinomial logistic regression analysis was used to identify factors associated with heterogeneity in intrinsic capacity.

Three latent profiles of intrinsic capacity were identified: the sensory-cognitive impairment group (n=28), the mobility-cognitive decline group (n=36), and the mobility-psychologically well group (n=126). Significant differences were observed among the three groups in sex, history of COVID-19 infection, age, body mass index, and lymphocyte count (χ²=15.172, 11.247; H=73.046, 10.695, 13.750; P < 0.01). Multivariate logistic regression analysis revealed that increased age (OR=1.115, 95%CI:1.059-1.173, P < 0.01) and abnormal lymphocyte count (OR=3.537, 95%CI: 1.325-9.442, P < 0.01) were independent risk factors for the sensory-cognitive impairment; increased age (OR=1.265, 95%CI:1.169-1.369, P < 0.01) and history of COVID-19 infection (OR=8.115, 95%CI: 1.945-33.854, P < 0.01) were independent risk factors for the mobility-cognitive decline.

Intrinsic capacity in community-dwelling older adults demonstrates considerable heterogeneity. Increased age, COVID-19 infection, and abnormal lymphocyte count may serve as potential screening indicators for differentiating distinct decline trajectories of intrinsic capacity. Community health practitioners should prioritize immunosenescence screening in high-risk older adults to enable early identification of populations with rapid intrinsic capacity decline and to implement targeted comprehensive interventions.

To explore the association between the chronic disease management index based on integrated chronic disease clinics and frailty in community-dwelling older patients with chronic diseases, so as to provide evidence for early prevention and control of frailty at primary healthcare institutions.

A convenience sampling method was used to recruit community-dwelling older patients with chronic diseases who were enrolled in the integrated chronic disease outpatient management program in Liangzhu Subdistrict, Hangzhou, from June to December 2025. A field survey was used to collect the patients’ general information, the Tilburg Frailty Indicator was used to assess their frailty status, and the patients’ chronic disease management index was extracted at the same time. Frailty-related indicators that were statistically significant in univariate analysis (Mann-Whitney U test, chi-square test, and Fisher's exact test) were included in a multivariable logistic regression model for further analysis. Receiver operating characteristic (ROC) curves were plotted to analyze the diagnostic performance of the chronic disease management index for frailty in community-dwelling older patients with chronic diseases.

A total of 161 community-dwelling older patients with chronic diseases were enrolled, including 45 frail patients (frailty group) and 116 non-frail patients (non-frailty group). There were statistically significant differences between the two groups in sex, age, weekly exercise frequency, types of chronic diseases, types of medications, and the chronic disease management index (P < 0.05 or P < 0.01). Logistic regression analysis showed that after adjusting for sex, age, weekly exercise frequency, types of chronic diseases, and types of medications, the chronic disease management index remained negatively associated with frailty (OR=0.845, 95%CI: 0.742-0.940, P < 0.01). ROC curve analysis showed that the area under the curve for the chronic disease management index in distinguishing frailty from non-frailty was 0.759 (95%CI: 0.680-0.839), with an optimal cutoff value of 81.25 points, a sensitivity of 84.4%, and a specificity of 59.5%.

The chronic disease management index is significantly negatively associated with frailty in community-dwelling older patients with chronic diseases. Primary healthcare institutions should pay close attention to older patients with chronic diseases who have low chronic disease management index scores, promptly conduct specialized frailty assessment and comprehensive intervention, and thereby delaying the progression of frailty.

To investigate the clinical efficacy of electrical stimulation biofeedback therapy combined with pelvic floor rehabilitation training in treating pelvic floor dysfunction in elderly women.

A total of 120 elderly female patients with pelvic floor dysfunction admitted to The Second Hospital of Tianjin Medical University from January 2023 to November 2025 were enrolled and divided into an observation group and a control group using a random number table method, with 60 patients in each group. The control group received pelvic floor rehabilitation training, while the observation group received electrical stimulation and biofeedback therapy combined with pelvic floor rehabilitation training. The total effective rate, pelvic floor muscle strength and pelvic floor function, urodynamic parameters, improvement in urinary incontinence symptoms, and the incidence of adverse reactions were compared between the two groups. The t-test was used for comparison of quantitative data, and the chi-square test or Fisher's exact test was used for comparison of categorical data.

The total effective rate after treatment in the observation group was significantly higher than that in the control group (χ²=7.212, P < 0.05). After treatment, the voltages of typeⅠand typeⅡpelvic floor muscle fibers, the fatigue degrees of typeⅠ and typeⅡ pelvic floor muscle fibers, maximum urinary flow rate, maximum urethral closure pressure, and abdominal leak point pressure in the observation group were significantly higher than those in the control group (t=4.126, 6.189, 5.347, 4.950, 6.410, 9.526, and 10.251, respectively, P < 0.01); the pelvic floor dysfunction clinical assessment scale score, 1-hour pad test result, and international consultation on incontinence questionnaire-urinary incontinence short form score were significantly lower than those in the control group (t=8.112, 4.134, and 5.311, respectively, P < 0.01). There was no statistically significant difference in the incidence of adverse reactions between the two groups (χ²=0.617, P > 0.05).

Electrical stimulation biofeedback therapy combined with pelvic floor rehabilitation training for pelvic floor dysfunction in elderly women can effectively enhance pelvic floor muscle strength and pelvic floor function, improve urodynamic parameters, alleviate urinary incontinence symptoms, and has a high safety profile.