Renal cell carcinoma (RCC) is a common malignancy of the urinary system, characterized by insidious early manifestations, marked heterogeneity, and a high risk of postoperative recurrence or metastasis in some patients. Current expert consensus indicates that conventional tissue biopsy and imaging modalities have inherent limitations in dynamic disease monitoring and the assessment of tumor heterogeneity. Due to its minimal invasiveness, repeatability, and capacity for real-time dynamic evaluation, liquid biopsy has become an important focus in precision oncology. Circulating tumor cells, circulating tumor DNA, exosomes, and non-coding RNAs are regarded as key liquid biopsy biomarkers in RCC. Among these, circular RNAs, long non-coding RNAs, and microRNAs have attracted increasing attention because of their relative stability and well-characterized regulatory functions, demonstrating considerable potential in the diagnosis, treatment monitoring, and prognostic assessment of RCC. Based on the latest evidencebased evidence and clinical practice from China and abroad, this consensus summarizes the current research and clinical utility of noncoding RNAs in liquid biopsy for RCC, and formulates five key consensus statements. These are intended to offer Chinese urologists more explicit references and standardized advice for the prevention and treatment of RCC, thereby further enhancing patient benefit.

To investigate the factors influencing sarcopenia among elderly patients attending medical institutions in southern Ningxia, and to provide evidence for the development of prevention and control strategies.

A total of 1 624 individuals aged 60 years and older who visited the Geriatric Departments of Ningnan Hospital, Guyuan People's Hospital, Xiji County People's Hospital, and other medical institutions between January and October 2025, were enrolled in this study. Basic demographic and lifestyle behavioral information were collected through questionnaires. Arm circumference, calf circumference, grip strength, 6meter gait speed, and appendicular skeletal muscle mass were measured. Multivariate Logistic regression models were used to analyze the independent influencing factors for possible sarcopenia and sarcopenia in the elderly population.

According to the 2019 Asian Working Group for Sarcopenia diagnostic criteria, the participants were classified into three groups: normal group (n=437, 26.9%), possible sarcopenia group (n=780, 48.0%), and sarcopenia group (n=407, 25.1%). Multivariate analysis revealed that aged≥70 years (possible sarcopenia: 70-79 years group OR=1.828, 95%CI: 1.342-2.491, 80 years group OR=3.140, 95%CI: 1.498-6.581; sarcopenia: 70-79 years group OR=2.581, 95%CI: 1.647-4.046,≥80 years group OR=9.570, 95%CI: 4.083-22.431), frailty (possible sarcopenia: OR=3.853, 95%CI: 2.061-7.204; sarcopenia: OR=3.973, 95%CI: 1.630-9.681), and high fall risk (possible sarcopenia: OR=12.446, 95%CI: 5.323-29.103; sarcopenia: OR=18.425, 95%CI: 6.637-51.154) were common risk factors for both possible sarcopenia and sarcopenia; monthly income≥3 000 CNY (possible sarcopenia: OR=0.580, 95%CI: 0.342-0.984; sarcopenia: OR=0.312, 95%CI: 0.126-0.771), higher mid-upper arm circumference (possible sarcopenia: OR=0.918, 95%CI: 0.848-0.994; sarcopenia: OR=0.725, 95%CI: 0.644-0.815) and calf circumference (possible sarcopenia: OR=0.819, 95%CI: 0.760-0.882; sarcopenia: OR=0.551, 95%CI: 0.494-0.614) were common protective factors for both conditions.

Aged≥70 years, frailty, and high fall risk are the main risk factors influencing sarcopenia in older adults in southern Ningxia. Early outpatient screening and timely interventions should be implemented for potentially highrisk populations to delay the onset and progression of sarcopenia.

To analyze the risk factors and construct a predictive model for postoperative intra-abdominal infection in elderly colorectal cancer patients, so as to provide a reference for early clinical identification and intervention.

Clinical data of elderly patients with colorectal cancer admitted to the First Hospital of Jiaxing from January 2017 to December 2023 were collected. Univariate and multivariate logistic regression analyses were performed to identify risk factors for postoperative intraabdominal infection and to develop a prediction model. The Hosmer-Lemeshow test was used to assess the goodness of fit of the model, and the receiver operating characteristic (ROC) curve was applied to evaluate its predictive performance.

A total of 1150 elderly surgical patients with colorectal cancer were included, among whom 97 (8.43%) developed intra-abdominal infection. There were statistically significant differences between elderly patients with colorectal cancer who had intraabdominal infections and those without intraabdominal infections in terms of preoperative abnormal liver function, preoperative glycated hemoglobin A1c (HbA1c), preoperative intestinal obstruction, Preoperative surgical risk classification standard-classification score, hospitalization costs, postoperative hospital stay, drainage tube indwelling time, anastomotic leakage, operation time, pathological stage, and combined organ resection (P < 0.05). Logistic regression analysis showed that elevated preoperative HbA1c (OR=1.480, 95%CI: 1.062-2.062, P < 0.05), postoperative hospital stay≥11 days (OR=7.920, 95%CI: 2.272-27.616, P < 0.05), drainage tube indwelling time≥9 days (OR=2.454, 95%CI: 1.114-5.404, P < 0.05), anastomotic leakage (OR=3.361, 95%CI: 1.125-10.042, P < 0.05), and surgical stage Ⅳ (OR=4.871, 95%CI: 1.126-21.067, P < 0.05) were independent risk factors for postoperative intra-abdominal infection. Based on these factors, a prediction model was constructed. The Hosmer-Lemeshow test showed that the model fit was good (χ²=5.007, P > 0.05), with an AUC value of 0.816 (95%CI: 0.771-0.862, P < 0.05). At the optimal probability threshold of 0.089, the model achieved a sensitivity of 89.09%, a specificity of 70.62%, and a Youden index of 0.5971.

Elevated preoperative HbA1c level, postoperative hospital stay≥11 days, drainage tube indwelling time≥9 days, anastomotic leakage, and surgical stage Ⅳ are independent risk factors for postoperative intraabdominal infection in elderly patients with colorectal cancer. The constructed predictive model shows good discriminative ability and can serve as a reference for early identification and intervention in clinical practice.

To explore the association between the serum creatinine-to-cystatin C ratio (CCR) and incident chronic pulmonary disease provide clinical evidence for the early intervention and treatment of lung diseases.

Based on data from the China Health and Retirement Longitudinal Study (CHARLS) collected between 2015 and 2018, the middleaged and elderly population without pulmonary disease in 2015 was used as the baseline, and followed up on pulmonary disease outcomes in 2018. Multivariable Cox proportional hazards regression was performed to assess the association of CCR with incident chronic pulmonary disease, with hazard ratios (HR) and 95%CI estimated. In the regression model, restricted cubic spline plots were used to explore the changing trend of the relationship between CCR and incident chronic pulmonary disease. Subgroup analysis was conducted based on the analysis of the multivariable Cox proportional hazards regression model.

A total of 8 366 subjects were included in the study. Among them, 657 individuals (7.9%) diagnosed with incident chronic pulmonary disease were divided into CCR-1, CCR-2, CCR-3, and CCR-4 groups according to the quartiles of CCR. Multivariable Cox proportional hazards regression analysis showed that, compared with the CCR-1 group, the multivariableadjusted HR(95%CI) for the CCR-2, CCR-3, and CCR-4 groups were 1.049 (0.847-1.300), 0.997 (0.793-1.254), and 0.700 (0.538-0.911), respectively. Restricted cubic spline analysis revealed a clear dose-response association of CCR with incident chronic pulmonary disease, and higher CCR was associated with a significantly lower risk of disease onset. No significant nonlinear trend was detected (overall P < 0.05 and nonlinearity P > 0.05). Subgroup analyses revealed no significant interactions between CCR and sex, age, hypertension, diabetes, or history of drinking and smoking (P > 0.05).

Higher CCR levels were significantly associated with a lower risk of incident chronic pulmonary disease, indicating a significant inverse association.

To investigate the effects of a novel ankle pump exercise monitor with realtime monitoring and feedback functions on the prevention of deep vein thrombosis (DVT) in elderly patients after hip fracture surgery.

A total of 120 elderly patients aged ≥60 years with hip fractures who were treated in the orthopedic department of a tertiary hospital in Zhejiang Province from January to December 2022 were enrolled using convenience sampling. The patients were divided into two groups by a random number table and were further divided into two subgroups according to surgical procedure (hip replacement versus intramedullary nailing). Both groups received routine postoperative care. The control group performed ankle pump exercises under the supervision of nurses, while the intervention group used the novel ankle pump exercise monitor with realtime monitoring and feedback functions to guide their training. The exercise training compliance rates were compared between the two groups during the intervention. D-dimer levels, and femoral and popliteal vein diameters and flow velocities were compared between the two groups at baseline and on day 7 after intervention. In addition, the increase in thigh circumference of the affected limb from baseline to day 7 was also compared between the two groups. Chisquare test or Fisher's exact test was used to compare the categorical data, and MannWhitney U test was used to compare the continuous data.

No statistically significant difference in the ankle pump exercise achievement rate was observed between the two groups on day 1 of intervention (χ²=0.323, P > 0.05). In contrast, the intervention group showed significantly higher ankle pump exercise achievement rates than the control group at day 3 and 7 postintervention (χ²=22.500, 30.531; P < 0.01). At baseline, no statistically significant differences were observed in any of the measured parameters between the two groups (P > 0.05). After intervention, the intervention group demonstrated significantly improved D-dimer levels, femoral and popliteal vein blood flow velocities, and popliteal vein diameter compared with the control group (Z=2.129, 2.141, 4.627, 2.655; P < 0.05 or P < 0.01). Regardless of whether patients underwent hip arthroplasty or intramedullary nailing, the intervention group demonstrated significantly improved D-dimer levels, femoral and popliteal vein blood flow velocities, and popliteal vein diameter compared with the control group after intervention (Z=2.031, 2.114, 3.987, 2.521; 2.118, 2.087, 3.654, 2.612; P < 0.05 or P < 0.01).

The novel ankle pump exercise monitor significantly enhances postoperative ankle pump exercise adherence, accelerates lower limb venous blood flow, reduces D-dimer levels, and decreases limb edema, showing good efficacy in preventing deep vein thrombosis in elderly hip fracture patients.

Aging-related bone disease (e.g., osteoarthritis and osteoporosis) and cardiovascular disease (e.g., hypertension, atherosclerosis, atrial fibrillation, and heart failure) are common chronic degenerative disease in the elderly population. In recent years, epidemiological studies have suggested that patients with osteoarthritis or osteoporosis may have an increased risk of cardiovascular events, while patients with cardiovascular disease may also exhibit bone loss, deterioration of bone microarchitecture, or aggravated joint degeneration. However, the causal direction and specific mechanistic links between these conditions remain incompletely defined. Current evidence indicates that inflammaging, oxidative stress, endocrine dysregulation, disordered mineral metabolism, metabolic reprogramming, impaired autophagy, and extracellular matrix remodeling may collectively contribute to pathological changes in bone, joint, vascular, and cardiac tissues. This review systematically summarizes recent advances in the comorbidity between aging-related bone disease and cardiovascular disease from two perspectives: shared risk factors and fundamental aging-related mechanisms, and disease-specific crosstalk mechanisms. It also discusses the limitations of existing evidence and the potential clinical translational value of this field, aiming to provide a reference for mechanistic research on bone-cardiovascular comorbidity and the optimization of integrated management strategies.