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Chinese Journal of Geriatrics Research(Electronic Edition) ›› 2025, Vol. 12 ›› Issue (01): 41-47. doi: 10.3760/cma.j.issn.2095-8757.2025.01.008

• Review • Previous Articles    

Advances in the relationship between mitochondrial dysfunction and signaling pathways associated with ischemic stroke among the elderly

Xueke Guang1, Chengyun Liu1, Weilin Lu1,()   

  1. 1. Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
  • Received:2024-09-18 Online:2025-02-28 Published:2025-06-17
  • Contact: Weilin Lu

Abstract:

As the global ageing trend intensifies, the number of elderly patients suffering from ischaemic stroke (IS) is increasing. It is therefore essential to identify effective targets for treatment and improve the prognosis of elderly stroke patients. Mitochondrial dysfunction is closely related to ageing,which affects neuronal viability and functional prognosis, is a key factor in the pathogenesis of IS. This paper reviews mitochondrial dysfunction and IS-related signaling pathways [nuclear factor erythroid 2 related factor (NRF2) signaling pathway, protein kinase RNA-like ER kinase (PERK) signaling pathway,Phosphoinositide 3-kinase /protein kinase B (PI3K/Akt) signaling pathway, cyclic GMP-AMP synthase(cGAS)-STING signaling pathway]by searching and analyzing the relevant literature, to provide new therapeutic strategies for preventing and treating ischemic stroke and decreasing the disability and mortality rates among the elderly.

Key words: Aged, Ischemic stroke, Mitochondrial dysfunction, Signal pathway

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