Diagnostic value of peripheral artery ultrasound indicators in elderly patients for peripheral arterial disease

doi:10.3877/cma.j.issn.2095-8757.2025.02.005

Abstract

Abstract:

Objective

To explore the diagnostic value of peripheral artery ultrasound indicators in elderly patients for peripheral arterial disease (PAD).

Methods

A total of 60 elderly patients diagnosed with PAD in Shaanxi Provincial Second People's Hospital from December 2020 to December 2023 (PAD group) and 60 healthy elderly individuals who underwent physical examination during the same period (healthy control group) were selected. Baseline data of both groups were collected. High-resolution ultrasound was used to detect carotid intima-media thickness (CIT), radial artery intima-media thickness (RIT), femoral artery intima-media thickness (PIT), plaque characteristics, hemodynamic parameters, and vascular wall elasticity, and their correlations with PAD were analyzed. The diagnostic efficacy of ultrasound indicators for PAD was evaluated using ROC curves. T test was used for the comparison between measurement data, and chi-square test was used for the comparison between counting data.

Results

Univariate analysis showed that CIT [(0.80±0.12) mm vs (0.65±0.11) mm, t=6.522, P < 0.05]、RIT[(0.70±0.11) mm vs (0.55±0.07) mm, t=7.525, P < 0.05]及PIT[(0.69±0.09) mm vs (0.51±0.06) mm, t=8.673, P < 0.001] in the PAD group were significantly higher than those in the healthy control group. Multivariate logistic regression analysis revealed that CIT, RIT, and PIT were all risk factors for PAD in the elderly [OR(95%CI)=1.682(1.351-2.103), 1.613(1.292-2.013), 1.512(1.231-1.852); P < 0.001]. ROC curve analysis indicated that CIT, RIT, and PIT had high AUC values for PAD diagnosis, and the combined application of the three indicators yielded the highest AUC (0.898), with a sensitivity of 87.53% and a specificity of 81.64%.

Conclusion

Increased thickness of CIT, RIT, and PIT is significantly associated with the occurrence of PAD in the elderly. The combined application of multiple indicators can effectively improve the diagnostic efficacy of PAD.

Key words: Aged, Peripheral arterial disease, Intima-media thickness, Diagnostic value

Furong Zhang, Xiaona Shang. Diagnostic value of peripheral artery ultrasound indicators in elderly patients for peripheral arterial disease[J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2025, 12(02): 24-28.

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References 26

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组别	例数	年龄（岁）	男性	BMI（kg/m²）	吸烟史	总胆固醇（mmol/L）	HDL-C（mmol/L）	LDL-C（mmol/L）
健康对照组	60	70.2±7.6	35（58.3）	25.4±3.2	9（15.00）	4.15±0.46	1.36±0.32	2.36±0.41
PAD组	60	71.2±8.1	33（55.0）	25.5±3.3	11（18.33）	4.37±0.43	1.27±0.29	2.45±0.41
检验值		t=1.854	χ²=0.140	t=-1.154	χ²=0.241	t=2.564	t=3.443	t=2.433
P值		>0.05	>0.05	>0.05	>0.05	>0.05	>0.05	>0.05

组别	例数	年龄（岁）	男性	BMI（kg/m²）	吸烟史	总胆固醇（mmol/L）	HDL-C（mmol/L）	LDL-C（mmol/L）
健康对照组	60	70.2±7.6	35（58.3）	25.4±3.2	9（15.00）	4.15±0.46	1.36±0.32	2.36±0.41
PAD组	60	71.2±8.1	33（55.0）	25.5±3.3	11（18.33）	4.37±0.43	1.27±0.29	2.45±0.41
检验值		t=1.854	χ²=0.140	t=-1.154	χ²=0.241	t=2.564	t=3.443	t=2.433
P值		>0.05	>0.05	>0.05	>0.05	>0.05	>0.05	>0.05

组别	例数	内膜中层厚度（mm）			PSV（cm/s）	EDV（cm/s）	RI	PWV（m/s）
组别	例数	颈动脉	桡动脉	股动脉	PSV（cm/s）	EDV（cm/s）	RI	PWV（m/s）
健康对照组	60	0.65±0.11	0.55±0.07	0.51±0.06	28.42±5.31	9.65±1.83	0.66±0.11	7.22±1.21
PAD组	60	0.80±0.12	0.70±0.11	0.69±0.09	32.23±6.82	11.12±2.53	0.75±0.12	8.51±1.52
t值		6.522	7.525	8.673	6.895	7.214	6.344	7.393
P值		<0.05	<0.05	<0.001	>0.05	>0.05	>0.05	>0.05

组别	例数	内膜中层厚度（mm）			PSV（cm/s）	EDV（cm/s）	RI	PWV（m/s）
组别	例数	颈动脉	桡动脉	股动脉	PSV（cm/s）	EDV（cm/s）	RI	PWV（m/s）
健康对照组	60	0.65±0.11	0.55±0.07	0.51±0.06	28.42±5.31	9.65±1.83	0.66±0.11	7.22±1.21
PAD组	60	0.80±0.12	0.70±0.11	0.69±0.09	32.23±6.82	11.12±2.53	0.75±0.12	8.51±1.52
t值		6.522	7.525	8.673	6.895	7.214	6.344	7.393
P值		<0.05	<0.05	<0.001	>0.05	>0.05	>0.05	>0.05

变量	b	SE	Wald χ²	P值	OR值	95%CI
CIT	0.521	0.098	28.363	<0.001	1.682	1.351-2.103
RIT	0.478	0.095	25.422	<0.001	1.613	1.292-2.013
PIT	0.415	0.089	21.791	<0.001	1.512	1.231-1.852
常量	-2.847	0.462	37.95	<0.001	0.058	-

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