To investigate the myocardial protection effect of erector spinae plane block for preemptive analgesia in elderly patients undergoing thoracoscopic radical surgery for lung cancer.

A total of 40 elderly patients who underwent thoracoscopic radical resection of lung cancer in Huizhou Central People's Hospital were selected. According to the wishes of patients, 19 patients were treated with ESPB combined with general anesthesia (observation group), and the other 21 patients were treated with simple general anesthesia (control group). Cardiac troponinⅠ(cTnⅠ), heart-type fatty acid binding protein (H-FABP) and creatine kinase isoenzyme (CK-MB) were detected at time points before induction (T0), at the beginning of surgery (T1), at the end of surgery (T2) and at 4 h after surgery (T3), and record the mean artery pressure (MAP) and heart rate at each time point. T test was used for comparison between groups, and repeated ANOVA was used for repeated measurement data.

The differences of MAP, heart rate, cTnⅠ, H-FABP and CK-MB between the two groups showed inter group effect, time effect and interaction effect (MAP: F=24.021, 33.512, 9.184, heart rate: F=10.340, 46.992, 3.494, cTnⅠ: F=5.354, 691.994, 64.177, H-FABP: F=7.906, 14.067, 11.560, CK-MB: F=15.926, 84.106, 4.116, P < 0.05 or P < 0.01). Compared with T0, MAP, heart rate, H-FABP and CK-MB showed significant changes at T1, T2 and T3 (P < 0.05), and cTnⅠ showed significant changes at T2 and T3 (P < 0.05).

The application of ESPB in advanced analgesia during thoracoscopic radical operation for elderly patients with lung cancer can significantly reduce the level of myocardial injury related factors and play a protective role in the myocardium.