Research progress on microRNA in the treatment of senile osteoarthritis

doi:10.3877/cma.j.issn.2095-8757.2020.03.012

Abstract

Abstract:

Osteoarthritis is one of the most common joint diseases in the elderly, but there are still many unresolved problems in the detailed pathogenesis. MicroRNA are small double-stranded RNA that negatively regulate gene expression, and play a key role in the differentiation, development and homeostasis of chondrocytes by participating in biological processes such as signaling pathway transduction, apoptosis and senescence, and autophagy. Numerous studies have shown that there are significant differences in the expression of microRNA in normal articular cartilage and senile osteoarthritis chondrocytes, and in animal models, intra-articular delivery of therapeutic microRNA has been shown to alleviate senile osteoarthritis, so some specific microRNA have been proposed as a circulating biomarker and novel therapeutic strategy for senile osteoarthritis. However, due to the differences in the groups and numbers of patients in each study, as well as the differences in the methods and scope of detection techniques, the results still need to be further verified. How to transform it into the treatment of senile osteoarthritis will be the next research focus in the future.

Key words: Aged, Osteoarthritis, MicroRNA, Treatment, Review

Xiyong Li, Su Yang, Xiongjie Zhang, Songfeng Li, Pengfei Han. Research progress on microRNA in the treatment of senile osteoarthritis[J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2022, 09(03): 51-55.

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References 38

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