The association between hyponatremia, falls, osteoporosis, and fracture

doi:10.3877/cma.j.issn.2095-8757.2018.03.009

Abstract

Abstract:

Hyponatremia is the most common electrolyte disorder encountered in clinical practice, and the incidence of hyponatremia rises with age. 75%~80% of hyponatremia are mild or moderate, of which are chronic and asymptomatic. Only 13~20% get treated. Several studies have demonstrated that the incidence of falls, osteoporosis and fracture is significantly associated with hyponatremia. 1/3 of the Na⁺ are stored in the bones. Whether Na⁺ balance disorders can cause changes in bone sodium and adverse consequences need to be studied.

Key words: Hyponatremia, Falls, Osteoporosis, Fracture

Yu Zhang, Xin Li, Xiao Leng, Lin Wang. The association between hyponatremia, falls, osteoporosis, and fracture[J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2018, 05(03): 41-44.

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References 28

[1]	张宇，王林.低钠血症研究进展[J].中华老年病研究电子杂志，2015，2（2）：32-39.
[2]	Nigro N, Winzeler B, Suter-Widmer I, et al. Symptoms and characteristics of individuals with profound hyponatremia: a prospective multicenter observational study[J]. J Am Geriatr Soc, 2015, 63(3):470-475.
[3]	Edmonds ZV. Pathophysiology, impact, and management of hyponatremia[J]. J Hosp Med, 2012, Suppl 4:S1-5.
[4]	张宇，李新，王林，等.9870例老年住院患者血钠和血钾水平及其紊乱危险因素分析[J].中华老年医学杂志，2016，35（6）：572-576.
[5]	张宇，王林，王仲言，等.单中心老年死亡患者电解质失衡调查及相关因素分析[J].中华老年病研究电子杂志，2015，2（3）：39-42.
[6]	Sejling AS, Thorsteinsson AL, Pedersen-Bjergaard U, et al. Recovery from SIADH-associated osteoporosis: a case report[J]. J Clin Endocrinol Metab, 2014, 99(10):3527-3530.
[7]	张宇，李新，王林，等.老年人骨质疏松及伴有低钠血症骨质疏松的临床研究[J].中华老年医学杂志，2017，37（8）：98-102.
[8]	Murthy K, Koshkina O, Marcantonio AJ, et al. Hyponatremia and fracture risk: a hospital-based case-control study[J]. J Am Geriatr Soc, 2015, 63(8):1699-1701.
[9]	Usala RL, Fernandez SJ, Mete M, et al. Hyponatremia is associated with increased osteoporosis and bone fractures in a large US health system population[J]. J Clin Endocrinol Metab, 2015, 100(8):3021-3031.
[10]	Sharif S, Dominguez M, Imbriano L, et al. Recognition of hyponatremia as a risk factor for hip fractures in older persons[J]. J Am Geriatr Soc, 2015, 63(9):1962-1964.
[11]	Soiza RL, Cumming K, Clarke JM, et al. Hyponatremia: Special considerations in older patients[J]. J Clin Med, 2014, 3(3):944-958.
[12]	Hagino T, Ochiai S, Watanabe Y, et al. Hyponatremia at admission is associated with in-hospital death in patients with hip fracture[J]. Arch Orthop Trauma Surg, 2013, 133(4):507-511.
[13]	Ayus JC, Fuentes NA, Negri AL, et al. Mild prolonged chronic hyponatremia and risk of hip fracture in the elderly[J]. Nephrol Dial Transplant, 2016, 31(10):1662-1669.
[14]	Gankam Kengne F, Andres C, Sattar L, et al. Mild hyponatremia and risk of fracture in the ambulatory elderly[J]. QJM, 2008, 101(7):583-588.
[15]	Gunathilake R, Oldmeadow C, McEvoy M, et al. Mild hyponatremia is associated with impaired cognition and falls in community-dwelling older persons[J]. 2013, 61(10):1838-1889.
[16]	Tachi T, Yokoi T, Goto C, et al. Hyponatremia and hypokalemia as risk factors for falls[J]. Eur J Clin Nutr, 2015, 69(2):205-210.
[17]	Ahamed S, Anpalahan M, Savvas S, et al. Hyponatraemia in older medical patients: implications for falls and adverse outcomes of hospitalisation[J]. Intern Med J, 2014, 44(10):991-997.
[18]	Holm JP, Amar AO, Hyldstrup L, et al. Hyponatremia, a risk factor for osteoporosis and ractures in women[J]. Osteoporos Int, 2016, 27(3):989-1001.
[19]	Afshinnia F, Sundaram B, Ackermann RJ, et al. Hyponatremia and osteoporosis: reappraisal of a novel association[J]. Osteoporos Int, 2015, 26(9):2291-2298.
[20]	Jamal SA, Arampatzis S, Harrison SL, et al. Hyponatremia and fractures: findings from the osteoporotic fractures in men study[J]. J Bone Miner Res, 2015, 30(6):970-975.
[21]	Kruse C, Eiken P, Vestergaard P. Hyponatremia and osteoporosis:insights from the Danish national patient registry[J]. Osteoporos Int, 2015, 26(3):1005-1016.
[22]	Kruse C, Eiken P, Verbalis J, et al. The effect of chronic mild hyponatremia on bone mineral loss evaluated by retrospective national Danish patient data[J]. Bone, 2016, 84:9-14.
[23]	Henriques M. Chronic hyponatremia: a new risk factor for fragility fractures in the elderly[J]? Acta Reumatol Port, 2015, 40(3):308-309.
[24]	周白瑜，石婧，于普林.北京市社区老年人跌倒情况及其后果的相关因素研究[J].中华流行病学杂志，2013，34（8）：778-781.
[25]	Hoorn EJ, Liamis G, Zietse R, et al. Hyponatremia and bone: an emerging relationship[J]. Nat Rev Endocrinol, 2011, 8(1):33-39.
[26]	Barsony J, Sugimura Y, Verbalis JG. Osteoclast response to low extracellular sodium and the mechanism of hyponatremia-induced bone loss[J]. J Biol Chem, 2011, 286(12):10864-10875.
[27]	Kizilgul M, Ozcelik O, Apaydin M, et al. Letter to the editor: possible mechanisms of hyponatremia-induced osteoporosis[J]. J Clin Endocrinol Metab, 2015, 100(10):L89-90.
[28]	Verbalis JG, Barsony J, Sugimura Y, et al. Hyponatremia-induced osteoporosis[J]. J Bone Miner Res, 2010, 25(3):554-563.

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