Advances in mechanism of intervertebral disc degeneration: The regulating role of melatonin

doi:10.3877/cma.j.issn.2095-8757.2022.04.011

Abstract

Abstract:

Melatonin and its metabolites have many physiological functions. In the pathophysiological environment, melatonin not only antagonizes inflammation and oxidative stress, but also regulates autophagy and apoptosis. This paper reviews the role and mechanism of melatonin in intervertebral disc aging and degeneration from aspects of inflammation, autophagy, oxidative stress, extracellular matrix metabolism and senescence of intervertebral disc cells, in order to provide ideas for the treatment of intervertebral disc degeneration diseases.

Key words: Melatonin, Intervertebral disc degeneration, Inflammation, Autophagy, Oxidative stress, Extracellular matrix, Cell senescence

Bin Lyu, Liangcong Hu, Xudong Xie, Bobin Mi, Jishan Yuan, Guohui Liu. Advances in mechanism of intervertebral disc degeneration: The regulating role of melatonin[J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2022, 09(04): 58-64.

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