Research progress on the role of short-chain fatty acids in the pathogenesis of sarcopenia

doi:10.3760/cma.j.issn.2095-8757.2024.04.006

Abstract

Abstract:

Sarcopenia is an age-related systemic skeletal muscle degenerative disease that seriously affects the quality of life and health of the elderly.In recent years， there have been an increasing number of studies on the relationship between intestinal flora and sarcopenia.Among them， shortchain fatty acids （SCFA）， the metabolites of intestinal flora， play an important role in the pathogenesis of sarcopenia.SCFA are involved in muscle mass and composition， inflammaging aging and immune senescence， mitochondrial dysfunction and oxidative stress， insulin resistance， hepatic uptake and metabolism， and blood flow metabolism in skeletal muscle， which directly or indirectly affect the gut microbe-muscle axis.Based on the aforementioned effects of SCFA， modification of dietary and exercise regimens， and supplementation with probiotics and prebiotics may be able to serve as interventions for sarcopenia.This paper further explore the potential role of SCFA in the pathogenesis of sarcopenia， to provide new ideas for the treatment of sarcopenia.

Key words: Sarcopenia, Short-chain fatty acids, Pathogenesis, Disease intervention

Guangning Wang, Yujie Li, Kunfan Gao, Huisong Liu. Research progress on the role of short-chain fatty acids in the pathogenesis of sarcopenia[J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2024, 11(04): 31-37.

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References 52

［1］	崔华，王朝晖，吴剑卿，等.老年人肌少症防控干预中国专家共识（2023）［J］.中华老年医学杂志，2023，42（2）：144-153.
［2］	Sayer AA， Cruz-Jentoft A.Sarcopenia definition， diagnosis and treatment： Consensus is growing［J］.Age Ageing， 2022，51（10）：afac220.
［3］	顾一航，缪健，胡心怡，等.老年综合评估筛查高龄肌少症危险因素的研究［J］.徐州医科大学学报，2023，43（1）：7-13.
［4］	Papadopoulou SK.Sarcopenia： A contemporary health problem among older adult populations［J］.Nutrients， 2020， 12（5）：1293.
［5］	Ticinesi A， Mancabelli L， Tagliaferri S， et al.The gut-muscle axis in older subjects with low muscle mass and performance： A proof of concept study exploring fecal microbiota composition and function with shotgun metagenomics sequencing［J］.Int J Mol Sci，2020， 21（23）：8946.
［6］	Han DS， Wu WK， Liu PY， et al.Differences in the gut microbiome and reduced fecal butyrate in elders with low skeletal muscle mass［J］.Clin Nutr， 2022， 41（7）：1491-1500.
［7］	He Y， Cui W， Fang T， et al.Metabolites of the gut microbiota may serve as precise diagnostic markers for sarcopenia in the elderly［J］.Front Microbiol， 2023， 14：1301805.
［8］	Rauf A， Khalil AA， Rahman UU， et al.Recent advances in the therapeutic application of short-chain fatty acids （SCFAs）： An updated review［J］.Crit Rev Food Sci Nutr， 2022， 62（22）：6034-6054.
［9］	周张宁，张勤，归崎峰，等.肠道微生态与肌少症研究新进展［J］.中华老年医学杂志，2022，41（5）：610-613.
［10］	黄少玲，宋国丽.肠道菌群代谢物在阿尔茨海默病中的作用及机制［J］.中华神经科杂志，2022，55（5）：524-528.
［11］	徐秋月，段勇.肠道菌群在冠心病中的作用机制及生物标志物应用进展［J］.中华检验医学杂志，2023，46（7）：748-753.
［12］	陈影，桂明，李丽雅.短链脂肪酸在风湿免疫病发病机制中的研究进展［J］.中华风湿病学杂志，2023，27（4）：272-276.
［13］	黄俊杰，郭玺.肠道菌群及其代谢物与动脉粥样硬化的关系［J］.中华心血管病杂志，2023，51（5）：548-554.：
［14］	van der Hee B， Wells JM.Microbial regulation of host physiology by short-chain fatty acids［J］.Trends Microbiol， 2021， 29（8）：700-712.
［15］	Yan J， Pan Y， Shao W， et al.Beneficial effect of the short-chain fatty acid propionate on vascular calcification through intestinal microbiota remodelling［J］.Microbiome， 2022， 10（1）：195.
［16］	Deleu S， Machiels K， Raes J， et al.Short chain fatty acids and its producing organisms： An overlooked therapy for IBD［J］？EBioMedicine， 2021， 66：103293.
［17］	Wang Z， Liu J， Li F， et al.The gut-lung axis in severe acute pancreatitis-associated lung injury： The protection by the gut microbiota through short-chain fatty acids［J］.Pharmacol Res，2022， 182：106321.
［18］	Liu P， Wang Y， Yang G， et al.The role of short-chain fatty acids in intestinal barrier function， inflammation， oxidative stress， and colonic carcinogenesis［J］.Pharmacol Res， 2021， 165：105420.
［19］	Takahashi D， Hoshina N， Kabumoto Y， et al.Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells［J］.EBioMedicine，2020， 58：102913.
［20］	He J， Zhang P， Shen L， et al.Short-chain fatty acids and their association with signalling pathways in inflammation， glucose and lipid metabolism［J］.Int J Mol Sci， 2020， 21（17）：6356.
［21］	Liu T， Sun Z， Yang Z， et al.Microbiota-derived short-chain fatty acids and modulation of host-derived peptides formation：Focused on host defense peptides［J］.Biomed Pharmacother， 2023，162：114586.
［22］	Mann ER， Lam YK， Uhlig HH.Short-chain fatty acids： Linking diet， the microbiome and immunity［J］.Nat Rev Immunol， 2024，24（8）：577-595.
［23］	王子豪，王宇，杨鑫，等.肠道菌群与骨质疏松症相关分子机制的研究进展［J］.中国微生态学杂志，2024，36（4）：487-492.
［24］	Gonzalez-Gil AM， Elizondo-Montemayor L.The role of exercise in the interplay between myokines， hepatokines， osteokines，adipokines， and modulation of inflammation for energy substrate redistribution and fat mass loss： A review［J］.Nutrients， 2020，12（6）：1899.
［25］	He M， Wei W， Zhang Y， et al.Gut microbial metabolites SCFAs and chronic kidney disease［J］.J Transl Med， 2024， 22（1）：172.
［26］	Yang Z， Tang C， Sun X， et al.Protective effects of SCFAs on organ injury and gut microbiota modulation in heat-stressed rats［J］.Ann Microbiol， 2024， 74：6.
［27］	Du Y， He C， An Y， et al.The role of short chain fatty acids in inflammation and body health［J］.Int J Mol Sci， 2024， 25（13）：7379.
［28］	Juban G.Transcriptional control of macrophage inflammatory shift during skeletal muscle regeneration［J］.Semin Cell Dev Biol，2021， 119：82-88.
［29］	李新科，杨雪，张萱，等.短链脂肪酸对肠道屏障保护作用的研究进展［J］.动物营养学报，2024，36（8）：4861-4871.
［30］	孔健达，徐欣然，陈世娟，等.肠道菌群合成的短链脂肪酸对运动表现的改善作用［J］.生理科学进展，2024，55（2）：91-98.
［31］	Liao X， Wu M， Hao Y， et al.Exploring the preventive effect and mechanism of senile sarcopenia based on "gut-muscle axis"［J］.Front Bioeng Biotechnol， 2020， 8：590869.
［32］	Pham NHT， Joglekar MV， Wong WKM， et al.Short-chain fatty acids and insulin sensitivity： A systematic review and metaanalysis［J］.Nutr Rev， 2024， 82（2）：193-209.
［33］	徐磊，倪震，张缨.运动、肠道菌群代谢物-短链脂肪酸与骨骼肌代谢调控［J］.中国生物化学与分子生物学报，2022，38（1）：1-7.
［34］	Frampton J， Murphy KG， Frost G， et al.Short-chain fatty acids as potential regulators of skeletal muscle metabolism and function［J］.Nat Metab， 2020， 2（9）：840-848.
［35］	Hays KE， Pfaffinger JM， Ryznar R.The interplay between gut microbiota， short-chain fatty acids， and implications for host health and disease［J］.Gut Microbes， 2024， 16（1）：2393270.
［36］	Jeong DY， Ryu MS， Yang HJ， et al.γ-PGA-rich chungkookjang，short-term fermented soybeans： Prevents memory impairment by modulating brain insulin sensitivity， neuro-inflammation， and the gut-microbiome-brain axis［J］.Foods， 2021， 10（2）：221.
［37］	Chen Y， Zhou J， Wang L.Role and mechanism of gut microbiota in human disease［J］.Front Cell Infect Microbiol， 2021， 11：625913.
［38］	Fraumene C， Manghina V， Cadoni E， et al.Caloric restriction promotes rapid expansion and long-lasting increase of Lactobacillus in the rat fecal microbiota［J］.Gut Microbes， 2018，9（2）：104-114.
［39］	Dong TS， Luu K， Lagishetty V， et al.A high protein calorie restriction diet alters the gut microbiome in obesity［J］.Nutrients，2020， 12（10）：3221.
［40］	Perry CA， Van Guilder GP， Kauffman A， et al.A calorie-restricted dash diet reduces body fat and maintains muscle strength in obese older adults［J］.Nutrients， 2019， 12（1）：102.
［41］	Park S， Shin BK.Intermittent fasting with a high-protein diet mitigated osteoarthritis symptoms by increasing lean body mass and reducing inflammation in osteoarthritic rats with Alzheimer's disease-like dementia［J］.Br J Nutr， 2022， 127（1）：55-67.
［42］	Ticinesi A， Lauretani F， Milani C， et al.Aging gut microbiota at the cross-road between nutrition， physical frailty， and sarcopenia：Is there a gut-muscle axis［J］？ Nutrients， 2017， 9（12）：1303.
［43］	Wu X， Unno T， Kang S， et al.A Korean-style balanced diet has a potential connection with Ruminococcaceae enterotype and reduction of metabolic syndrome incidence in Korean adults［J］.Nutrients， 2021， 13（2）：495.
［44］	Cruz-Jentoft AJ， Dawson Hughes B， Scott D， et al.Nutritional strategies for maintaining muscle mass and strength from middle age to later life： A narrative review［J］.Maturitas， 2020， 132：57-64.
［45］	Donati Zeppa S， Agostini D， Gervasi M， et al.Mutual interactions among exercise， sport supplements and microbiota［J］.Nutrients，2019， 12（1）：17.
［46］	Yang A， Lv Q， Chen F， et al.The effect of vitamin D on sarcopenia depends on the level of physical activity in older adults［J］.J Cachexia Sarcopenia Muscle， 2020， 11（3）：678-689.
［47］	Huang WC， Hsu YJ， Li H， et al.Effect of Lactobacillus plantarum TWK10 on improving endurance performance in humans［J］.Chin J Physiol， 2018， 61（3）：163-170.
［48］	Huang WC， Lee MC， Lee CC， et al.Effect of Lactobacillus plantarum TWK10 on exercise physiological adaptation，performance， and body composition in healthy humans［J］.Nutrients， 2019， 11（11）：2836.
［49］	Chen YM， Wei L， Chiu YS， et al.Lactobacillus plantarum TWK10 supplementation improves exercise performance and increases muscle mass in mice［J］.Nutrients， 2016， 8（4）：205.
［50］	Wieërs G， Belkhir L， Enaud R， et al.How probiotics affect the microbiota［J］.Front Cell Infect Microbiol， 2020， 9：454.
［51］	Liu C， Cheung WH， Li J， et al.Understanding the gut microbiota and sarcopenia： a systematic review［J］.J Cachexia Sarcopenia Muscle， 2021， 12（6）：1393-1407.
［52］	Rodriguez J， Delzenne NM.Modulation of the gut microbiotaadipose tissue-muscle interactions by prebiotics［J］.J Endocrinol，2021， 249（1）：R1-R23.

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