Progress in research on kidney aging

doi:10.3877/cma.j.issn.2095-8757.2025.03.006

Abstract

Abstract:

The kidneys, as an important metabolic and excretory organ in the human body, undertake crucial physiological functions such as eliminating metabolic waste, regulating water and salt balance, and maintaining acid-base homeostasis. With the increase of age, the kidneys undergo progressive functional decline, accompanied by significant macroscopic and microscopic histological changes. This age-related renal function impairment has become an important issue urgently needing to be addressed in clinical practice. In-depth research on the pathological features of kidney aging is of great significance for understanding and improving age-related renal injury. From the molecular mechanism perspective, cellular aging plays a decisive role in the aging process of the kidneys and involves multiple cell signal transduction pathways. These pathways provide potential intervention targets for delaying or reversing kidney aging. Therefore, systematic research on the molecular mechanism of kidney aging and its clinical significance is of great value for the early diagnosis in clinical practice, the delay of kidney aging, and the development of new treatment strategies for kidney diseases. This article focuses on the pathological features, molecular mechanisms, and potential treatment directions of kidney aging, providing new ideas for related research and clinical practice.

Key words: Kidney, Aging, Pathological features, Molecular mechanism, Kidney disease

Qing Ouyang, Rukun He, Jun Chen. Progress in research on kidney aging[J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2025, 12(03): 39-46.

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