The association between hyperuricemia and coronary artery calcification

doi:10.3877/cma.j.issn.2095-8757.2023.04.008

Abstract

Abstract:

Hyperuricemia is a common metabolic disease, whose pathological damage is not limited to kidney, joint and other parts, but can cause a series of systemic inflammatory reactions. Studies have found that hyperuricemia may promote the occurrence and development of coronary artery calcification by promoting inflammatory response and inducing oxidative stress, and interact with coronary heart disease risk factors such as hypertension and diabetes to increase the risk of coronary artery calcification. At the genetic level, mendelian randomization studies have also provided new evidence for the association between hyperuricemia and coronary artery disease. This article reviews the relationship between hyperuricemia and coronary artery calcification, aiming to clarify the possible mechanism of hyperuricemia affecting coronary artery calcification, and provide new ideas for the prevention and treatment of coronary artery calcification.

Key words: Hyperuricemia, Coronary artery calcification, Inflammation, Oxidative stress, Comorbidities, Genetics, Review

Xiaoyan Gong, Qingwei Chen. The association between hyperuricemia and coronary artery calcification[J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2023, 10(04): 47-49.

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References 22

[1]	Chen-Xu M, Yokose C, Rai SK, et al. Contemporary prevalence of gout and hyperuricemia in the United States and decadal trends: The National Health and Nutrition Examination Survey, 2007-2016[J]. Arthritis Rheumatol, 2019, 71(6):991-999.
[2]	Liu R, Han C, Wu D, et al. Prevalence of hyperuricemia and gout in mainland China from 2000 to 2014: A systematic review and meta-analysis[J]. Biomed Res Int, 2015, 2015:762820.
[3]	Li Y, Shen Z, Zhu B, et al. Demographic, regional and temporal trends of hyperuricemia epidemics in mainland China from 2000 to 2019: A systematic review and meta-analysis[J]. Glob Health Action, 2021, 14(1):1874652.
[4]	Jun JE, Lee YB, Lee SE, et al. Elevated serum uric acid predicts the development of moderate coronary artery calcification independent of conventional cardiovascular risk factors[J]. Atherosclerosis, 2018, 272:233-239.
[5]	Kiss LZ, Bagyura Z, Csobay-Novák C, et al. Serum uric acid is independently associated with coronary calcification in an asymptomatic population[J]. J Cardiovasc Transl Res, 2019, 12(3):204-210.
[6]	Liang L, Hou X, Bainey KR, et al. The association between hyperuricemia and coronary artery calcification development: A systematic review and meta-analysis[J]. Clin Cardiol, 2019, 42(11):1079-1086.
[7]	Wang X, Liu X, Qi Y, et al. High level of serum uric acid induced monocyte inflammation is related to coronary calcium deposition in the middle-aged and elder population of China: A five-year prospective cohort study[J]. J Inflamm Res, 2022, 15:1859-1872.
[8]	Luis-Rodríguez D, Donate-Correa J, Martín-Núñez E, et al. Serum urate is related to subclinical inflammation in asymptomatic hyperuricaemia[J]. Rheumatology (Oxford), 2021, 60(1):371-379.
[9]	Agrawal M, Niroula A, Cunin P, et al. TET2-mutant clonal hematopoiesis and risk of gout[J]. Blood, 2022,140(10):1094-1103.
[10]	Doğru S, Yaşar E, Yeşilkaya A. Uric acid can enhance MAPK pathway-mediated proliferation in rat primary vascular smooth muscle cells via controlling of mitochondria and caspase-dependent cell death[J]. J Recept Signal Transduct Res, 2022, 42(3):293-301.
[11]	Kimura Y, Yanagida T, Onda A, et al. Soluble uric acid promotes atherosclerosis via ampk (amp-activated protein kinase)-mediated inflammation[J]. Arterioscler Thromb Vasc Biol, 2020, 40(3):570-582.
[12]	Chen M, Lu X, Lu C, et al. Soluble uric acid increases PDZK1 and ABCG2 expression in human intestinal cell lines via the TLR4-NLRP3 inflammasome and PI3K/Akt signaling pathway[J]. Arthritis Res Ther, 2018,20(1):20.
[13]	Roumeliotis S, Roumeliotis A, Dounousi E, et al. Dietary antioxidant supplements and uric acid in chronic kidney disease: A review[J]. Nutrients, 2019, 11(8):1911.
[14]	Song C, Zhao X. Uric acid promotes oxidative stress and enhances vascular endothelial cell apoptosis in rats with middle cerebral artery occlusion[J]. Biosci Rep, 2018, 38(3):BSR20170939.
[15]	Borghi C, Rosei EA, Bardin T, et al. Serum uric acid and the risk of cardiovascular and renal disease[J]. J Hypertens, 2015, 33(9):1729-1741.
[16]	Yuan H, Yu C, Li X, et al. Serum uric acid levels and risk of metabolic syndrome: A dose-response meta-analysis of prospective studies[J]. J Clin Endocrinol Metab, 2015, 100(11):4198-4207.
[17]	Wang J, Qin T, Chen J, et al. Hyperuricemia and risk of incident hypertension: A systematic review and meta-analysis of observational studies[J/OL]. PLoS One, 2014, 9(12):e114259.
[18]	Lv Q, Meng XF, He FF, et al. High serum uric acid and increased risk of type 2 diabetes: A systemic review and meta-analysis of prospective cohort studies[J/OL]. PLoS One, 2013, 8(2):e56864.
[19]	Maloberti A, Biolcati M, Ruzzenenti G, et al. The role of uric acid in acute and chronic coronary syndromes[J]. J Clin Med, 2021,10(20):4750.
[20]	White J, Sofat R, Hemani G, et al. Plasma urate concentration and risk of coronary heart disease: A Mendelian randomisation analysis[J]. Lancet Diabetes Endocrinol, 2016, 4(4):327-336.
[21]	Kleber ME, Delgado G, Grammer TB, et al. Uric acid and cardiovascular events: A mendelian randomization study[J]. J Am Soc Nephrol, 2015, 26(11):2831-2838.
[22]	Borghi C, Domienik-Karłowicz J, Tykarski A, et al. Expert consensus for the diagnosis and treatment of patient with hyperuricemia and high cardiovascular risk: 2021 update[J]. Cardiol J, 2021, 28(1):1-14.

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