To study the therapeutic effects of endoscopic submucosal dissection (ESD) in the treatment of early gastric cancer.

200 patients with early gastric cancer admitted to the Second Hospital of Tianjin Medical University from February, 2017 to January, 2020 were randomly divided into control group (100 cases) and study group (100 cases). The control group underwent endoscopic mucosal resection (EMR), while the study group underwent ESD. Observe the lesion resection status, surgical indicators, pepsinogen (PG) levels, and prognosis of two groups using t test or χ² test.

The lesion resection area, gastric cancer mass resection rate, gastric cancer complete resection rate, and gastric cancer curative resection rate of the study group were all higher than those of the control group (t=25.610; χ²=4.301, 4.247 and 4.046; P < 0.05). Compared with the control group, the intraoperative bleeding volume was lower (t=17.663, P < 0.05) and the hospital stay was shorter (t=11.330, P < 0.05) in the study group. 7 days after surgery, compared with the control group, the study group had higher PGI and PGI/PGII (t=5.056 and 9.951, P < 0.05), and lower PGII (t=7.455, P < 0.05). The overall incidence of complications in the study group was lower than that in the control group (χ²=3.988, P < 0.05).

Compared with EMR, ESD treatment for early gastric cancer can better remove tumor tissue, reduce bleeding, improve PG levels, shorten hospital stay, and reduce the incidence of complications.