To observe the hemostatic effects of hemocoagulase and epinephrine on airway bleeding caused by fibrobronchoscopy.

160 patients in whom fibrobronchoscopy for airway diseases produced bleeding were enrolled and Adopt random figure table, randomized into A and B groups between Jan, 2011 and Dec, 2014, A group treated with hemocoagulase (n=80) and B group with epinephrine (n=80). The aforesaid drugs were immediately injected locally once bleeding due to fibrobronchoscopy. A group were given 2-4 units of hemocoagulase diluted in saline, and B group were given 0.5-2 mg of epinephrine at 1:10 000 dilution. Hemostatic effects were observed at 10, 20, and 30 seconds in biopsy locations, blood in sputum 12, and 24 h post operation, and complications including HR≥100 bpm, SBP≥150 mmHg, DBP≥95 mmHg, SPO₂decreased≥10%, palpitation, dyspnea, headache, and paleness were recorded.χ²test was applied to compare between groups.

At 10 seconds hemostatic effects of epinephrine were better than hemocoagulase, at 20 and 30 seconds hemostatic effects of the two drugs had no significant difference (χ²=2.770, 1.440, 1.290, 0.360, P> 0.05). Incidence of bloody sputum at 12 and 24h were significantly lower in A group (χ²=5.370, 5.770,P< 0.01). Presentations of elevated heart rate, increased blood pressure, declined blood oxygen saturation, palpitation, chest distress were significantly less in A group (χ²=13.580, 17.320, 13.090, 12.690, 10.420, 4.100, 5.620,P< 0.05 or 0.01).

Hemostatic effects of hemocoagulase and epinephrine are similar. Hemocoagulase treatment has less complications compared with epinephrine. Hemocoagulase should be the first choice of hemostatic therapy for older adults.