Alzheimer's disease (AD) is a neurodegenerative disease characterized by memory loss and cognitive impairment, which has the highest incidence in the world. Pyroptosis is an inflammatory programmed cell death pattern discovered in recent years. Studies have shown that AD is closely related to pyroptosis. It has been confirmed that amyloid-beta protein and Tau proteins are involved in the occurrence of pyroptosis, and inflammasome and pro-inflammatory cytokines are involved in the pathogenesis of AD in the pathway of pyroptosis activation. Pyroptosis may be the main form of neuronal death. Pyroptosis mediated neuroinflammation plays a central role in the pathogenesis and progression of AD. Inhibition of pyroptosis and downstream inflammatory processes can alleviate the related pathological changes of AD and provide a new clinical therapeutic target.