Expression and significance of circular RNA in serum of elderly patients with chronic obstructive pulmonary disease

doi:10.3877/cma.j.issn.2095-8757.2020.02.008

Abstract

Abstract:

Objective

To investigate the expression and clinical significance of circular RNA (circRNA) in serum of elderly patients with chronic obstructive pulmonary disease (COPD).

Methods

80 elderly patients with COPD admitted to Lianyungang second people's Hospital from January 2014 to December 2016 were selected (observation group), and 30 healthy people were selected as the control group at the same time. The expression of serum circRNA-001988, circRNA-0000344 and circRNA-0000284 were detected and compared between the two groups. T test was used for comparison between two groups.

Results

The expressions of serum circrNA-001988, CIRcrNa-0000344 and circrNa-0000284 were all abnormal in the observation group. Compared with the control group, the expressions of circrna-001988 and circrna-0000344 in the observation group were decreased by (6.54±2.75) and (5.94±2.89) times respectively (t=3.176, 2.659, P < 0.05), and the expression of circrna-0000284 was (8.54±3.25) times higher than that of the control group (t=4.535, P < 0.05).

Conclusion

Serum circRNA level can be used as a biomarker for diagnosis and prognosis of COPD, and it has clinical predictive value.

Key words: circRNA, Chronic obstructive pulmonary disease, Diagnosis, Predictive

Futao Chen, Fukuan Zhong, Qiaohong Bai, Guangrong Bian, Ju Yang, Jiang Zhu. Expression and significance of circular RNA in serum of elderly patients with chronic obstructive pulmonary disease[J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2020, 07(02): 32-35.

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