Clinical efficiency of hyperbaric oxygen combined with alteplase on acute ischemic stroke

doi:10.3877/cma.j.issn.2095-8757.2019.02.005

Abstract

Abstract:

Objective

To investigate the clinical efficacy of hyperbaric oxygen combined with alteplase in the treatment of acute ischemic stroke (AIS).

Methods

38 patients with AIS were recruited from July 2016 to July 2017 in Taian City Central Hospital, and they were divided into two groups: 18 patients were treated by hyperbaric oxygen combined with alteplase intravenous thrombolysis (observation group), 20 patients were only treated by Alteplase intravenous thrombolysis (control group). All patients were treated with alteplase intravenous thrombolysis within 3 hours after the onset of symptoms, and they were assessed before the treatment, 2 hours, 24 hours and 7 days after the treatment according to NIHSS and modified Rank in Scale (mRS).

Results

The NIHSS score of the observation group was significantly higher than that of the control group before the treatment (t = 4.216, P<0.01). The NIHSS scores of the observation group at 2 h, 24 h, 7 d and 90 d after the treatment were significantly lower than those of the control group (t = -3.957, -3.975, -2.184, -1.296, P<0.01), and the mRS of 90 days after onset in the observation group was also significantly lower than that in the control group (t = -1.960, P<0.01).

Conclusion

Hyperbaric oxygen combined with alteplase intravenous thrombolysis can improve the neurological function of patients in the early stage of AIS.

Key words: Hyperbaric oxygen, Alteplase, Intravenous thrombolysis, Acute ischemic stroke

Juan Li, Wenhui Zhang, Fangbo Ning, Shen Yang, Xuexia Ma, Fangfang Zhao. Clinical efficiency of hyperbaric oxygen combined with alteplase on acute ischemic stroke[J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2019, 06(02): 44-47.

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References 8

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组别	例数	性别（男/女，例）	年龄（岁）	90 d死亡情况[例(%)]	出血转化[例(%)]
观察组	18	11/7	45～75（62.12±12.45）	2（11.1）	0（0）
对照组	20	12/8	55～78（63.45±10.37）	3（15.0）	1（5.0）
检验值	?	χ²=1.143	t=-1.414	χ²=1.147	χ²=1.406
P值	?	>0.05	>0.05	>0.05	>0.05
组别	例数	肢体瘫痪[例(%)]	失语[例(%)]	高血压[例(%)]	糖尿病[例(%)]	房颤[例(%)]	冠心病[例(%)]
观察组	18	18（100）	10（55.6）	14（77.8）	9（50.0）	5（27.7）	14（77.8）
对照组	20	20（100）	11（55.0）	16（80.0）	11（55.0）	6（30.0）	15（75.0）
检验值	?	χ²=2.333	χ²=0.938	χ²=2.019	χ²=1.587	χ²=0.744	χ²=0.012
P值	?	>0.05	>0.05	>0.05	>0.05	>0.05	>0.05

组别	例数	性别（男/女，例）	年龄（岁）	90 d死亡情况[例(%)]	出血转化[例(%)]
观察组	18	11/7	45～75（62.12±12.45）	2（11.1）	0（0）
对照组	20	12/8	55～78（63.45±10.37）	3（15.0）	1（5.0）
检验值	?	χ²=1.143	t=-1.414	χ²=1.147	χ²=1.406
P值	?	>0.05	>0.05	>0.05	>0.05
组别	例数	肢体瘫痪[例(%)]	失语[例(%)]	高血压[例(%)]	糖尿病[例(%)]	房颤[例(%)]	冠心病[例(%)]
观察组	18	18（100）	10（55.6）	14（77.8）	9（50.0）	5（27.7）	14（77.8）
对照组	20	20（100）	11（55.0）	16（80.0）	11（55.0）	6（30.0）	15（75.0）
检验值	?	χ²=2.333	χ²=0.938	χ²=2.019	χ²=1.587	χ²=0.744	χ²=0.012
P值	?	>0.05	>0.05	>0.05	>0.05	>0.05	>0.05

组别	例数	NIHSS评分					发病90 d mRS评分
组别	例数	入院时	溶栓后2 h	溶栓后24 h	溶栓后7 d	发病90 d	发病90 d mRS评分
观察组	18	16.8±2.7	9.8±2.1	6.5±1.8	4.2±0.6	3.8±0.5	2.5±0.3
对照组	20	15.9±3.1	11.8±3.3	8.8±2.1	5.2±1.6	4.2±1.1	3.1±0.4
t值	?	4.216	-3.957	-3.975	-2.184	-1.296	-1.960
P值	?	<0.01	<0.01	<0.01	<0.05	>0.05	>0.05

组别	例数	NIHSS评分					发病90 d mRS评分
组别	例数	入院时	溶栓后2 h	溶栓后24 h	溶栓后7 d	发病90 d	发病90 d mRS评分
观察组	18	16.8±2.7	9.8±2.1	6.5±1.8	4.2±0.6	3.8±0.5	2.5±0.3
对照组	20	15.9±3.1	11.8±3.3	8.8±2.1	5.2±1.6	4.2±1.1	3.1±0.4
t值	?	4.216	-3.957	-3.975	-2.184	-1.296	-1.960
P值	?	<0.01	<0.01	<0.01	<0.05	>0.05	>0.05

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