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Chinese Journal of Geriatrics Research(Electronic Edition) ›› 2019, Vol. 06 ›› Issue (02): 35-39. doi: 10.3877/cma.j.issn.2095-8757.2019.02.003

Special Issue:

• Review • Previous Articles     Next Articles

Effect of internal environment on renal aging

Hengda Zhang1, Chao Liu1, Xuefeng Sun1,()   

  1. 1. Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing 100853, China
  • Received:2019-01-30 Online:2019-05-28 Published:2019-05-28
  • Contact: Xuefeng Sun
  • About author:
    Corresponding author: Sun Xuefeng, Email:

Abstract:

Renal aging is the basis of renal disease in the elderly. The internal environment affects organ aging by regulating apoptosis, autophagy, inflammation, regeneration and repair. In this paper, we summarize our research on the effects of the internal environment on renal aging, and reviews the literature at home and abroad, introduce the establishment of animal models of internal environment affecting renal aging and the research progress of the mechanisms affecting renal aging and elderly renal diseases, and put forward some research proposal. To provide some valuable reference for related basic research and clinical transformation.

Key words: Renal aging, Internal environment, Animal model, Mechanism, Research progress

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