The role of mitochondrial DNA in pathogenesis of pulmonary fibrosis

doi:10.3877/cma.j.issn.2095-8757.2018.01.008

Abstract

Abstract:

Mitochondrial DNA (mtDNA) encoding 13 proteins, is one of the most important genetic material in vivo. mtDNA can be easily damaged by reactive oxygen species. Recent studies have found that mtDNA damage can lead to mitochondrial dysfunction, which is linked with pulmonary epithelial cell apoptosis and the pathogenesis of pulmonary fibrosis. Maintaining mtDNA integrity may provide new therapeutic targets for the treatment of pulmonary fibrosis. The work reviews the role of mtDNA in the pulmonary fibrosis and the advances of mtDNA damage repair mechanisms.

Key words: Mitochondrial DNA, Pulmonary fibrosis, Reactive oxygen species, Research progress

Tongtong Xue, Xuejun Liu, Yufeng Du. The role of mitochondrial DNA in pathogenesis of pulmonary fibrosis[J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2018, 05(01): 43-48.

/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://zhlnbyjdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-8757.2018.01.008

https://zhlnbyjdzzz.cma-cmc.com.cn/EN/Y2018/V05/I01/43

References 24

[1]	Caminati A,Madotto F,Cesana G, et al. Epidemiologicalstudies in idiopathic pulmonary fibrosis：pitfalls in methodologiesand data interpretation[J].Eur Respir Rev, 2015, 24(137):436-444．
[2]	Anderson S. Shotgun DNA sequencing using cloned DNase I-generated fragments[J]. Nucleic Acids Res, 1981, 9(13):3015-3027.
[3]	Zhang D,Wang L,Guo H, et al. Complete mitochondrial genome of Florida pompano Trachinotus carolinus ( Teleostei, Carangidae)[J]. Mitochondrial DNA A DNA Mapp Seq Anal, 2016, 27(1):597-598.
[4]	Held NM,Houtkooper RH. Mitochondrial quality control pathways as determinants of metabolic health[J]. Bioessays 2015, 37(8):867-876.
[5]	Gazdhar A,Lebrecht D,Roth M, et al. Time-dependent and somatically acquired mitochondrial DNA mutagenesis and respiratory chain dysfunction in a scleroderma model of lung fibrosis[J].Sci Rep, 2014, 4:5336.
[6]	Rowlands DJ. Mitochondria dysfunction: A novel therapeutic target in pathological lung remodeling or bystander[J]? Pharmacol Ther, 2016, 166:96-105.
[7]	Cheresh P,Kim SJ,Tulasiram S, et al. Oxidative stress and pulmonary fibrosis[J]. Biochim Biophys Acta, 2013, 1832(7):1028-1040.
[8]	Merrill WW,Reynolds HY. Bronchial lavage in inflammatory lung disease[J]. Clin Chest Med，1983, 4(1):71-84.
[9]	Baroke E,Gauldie J,Kolb M. New treatment and markers of prognosis for idiopathic pulmonary fibrosis: lessons learned from translational research[J]. Expert Rev Respir Med, 2013, 7(5):465-478.
[10]	King TE Jr,Pardo A,Selman M. Idiopathic pulmonary fibrosis[J]. Lancet, 2011, 378(9807):1949-1961.
[11]	Noble PW,Barkauskas CE,Jiang D. Pulmonary fibrosis:patternsand perpetrators[J]. J Clin Invest, 2012, 122(8):2756-2762.
[12]	Wang XM,Chen JJ,Lancaster L, et al. Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis[J]. J Exp Med, 2006, 203(13):2895-2906.
[13]	Chilosi M,Carloni A,Rossi A, et al. Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema.[J]. Transl Res, 2013, 162(3):156-173.
[14]	Bao L,Diao H,Dong N, et al. Histone deacetylase inhibitor induces cell apoptosis and cycle arrest in lung cancer cells via mitochondrial injury and p53 up-acetylation[J]. Cell Biol Toxicol, 2016, 32(6):469-482.
[15]	Wallace DC. A mitochondrial bioenergetic etiology of disease[J]. J Clin Invest, 2013, 123(4):1405-1412.
[16]	Wang Z,Choi S,Lee J, et al. Mitochondrial variations in non-small cell lung cancer (NSCLC) survival[J]. Cancer Inform, 2015, 14(Suppl):1-9.
[17]	Schumacker PT,Gillespie MN,Nakahira K, et al. Mitochondria in lung biology and pathology: More than just a powerhouse[J]. Am J Physiol Lung Cell Mol Physiol, 2014, 306(11):L962–L974.
[18]	Ganta KK,Mandal A,Chaubey B. Depolarization of mitochondrial membrane potential is the initial event in non-nucleoside reverse transcriptase inhibitor efavirenz induced cytotoxicity[J]. Cell Biol Toxicol, 2017, 33(1):69-82.
[19]	Kim SJ,Cheresh P,Williams D, et al. Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells[J]. J Biol Chem, 2014, 289(9):6165-6176.
[20]	Cheresh P,Morales-Nebreda L,Kim SJ, et al. Asbestos-induced pulmonary fibrosis is augmented in 8-oxoguanine DNA glycosylase knockout mice[J]. Am J Respir Cell Mol Biol, 2015, 52(1):25-36.
[21]	Kaniak-Golik A,Skoneczna A. Mitochondria-nucleus network for genome stability[J]. Free Radic Biol Med, 2015, 82:73-104.
[22]	Kincaid B,Bossy-Wetzel E. Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration[J]. Front Aging Neurosci, 2013, 5:48.
[23]	Bindu S,Pillai VB,Kanwal A, et al. SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage[J]. Am J Physiol Lung Cell Mol Physiol, 2017, 312(1): L68-L78.
[24]	Sosulski ML,Gongora R,Feghali-bostwick C, et al. Sirtuin 3 deregulation promotes pulmonary fibrosis[J]. J Gerontol A Biol Sci Med Sci, 2017, 72(5): 595-602.

Please choose a citation manager

Content to export