Proinflammatory Signaling in Arterial Aging

doi:10.3877/cma.j.issn.2095-8757.2016.03.008

Abstract

Abstract:

Arterial aging is an essential element of the systemic aging. With advanced age, angiotensin II (Ang II) and its signaling cascades are chronically activated, leading to a low-grade inflammation (proinflammation) in the cardiovascular system. Ang II signaling and its downstream target molecules play a key role in arterial remodeling and dysfunction with aging. This brief review focuses on the proinflammatory molecules in the arterial wall and the signaling pathways of Ang II, which provides an insight into the underlying molecular mechanisms behind arterial aging but also reveals novel potential molecular targets to prevent and treat arterial aging and age-associated arterial disease.

Key words: Aging, Inflammation, Signal transduction, Vascular Remodeling

Li Zhang, Yu Liu, Yushi Wang, Yi Huang, Da Lei, Yang Zheng, Cuntai Zhang, Mingyi Wang. Proinflammatory Signaling in Arterial Aging[J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2016, 03(03): 28-32.

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