To evaluation the correlation of serum NT-proBNP and its changes on prognosis of maintenance hemodialysis patients.

We randomly selected 300 cases of maintenance hemodialysis patients from blood purification center in our hospital. Serum NT-proBNP concentrations were determined at the beginning and after 6 months of dialysis respectively, and followed up the subjects for 1 year. complications and mortality were analyzed the as the effects of NT-proBNP levels and its changes.T-test was further used to dertermined differences between two groups which appeared normal distribution, Rank sum test was further used to dertermined differences between two groups which appeared non-normal distribution. Chi-Square was further used to dertermined differences between count data. Logistic regression analysis was used to test the influence factors.

NT-proBNP levels of 300 maintenance dialysis patients were significantly increased.(1) The primary disease, vascular access and the NT-proBNP levels are associated with cardio cerebral vascular complication in these patients (χ²=7.670、5.293,Z=-2.374,-2.787;P<0.05 or 0.01). All other factors were not correlated with the complications (P>0.05). Sex, age, primary diseases, vascular access, year of dialysis, NT-proBNP at baseline and 6 months after dialysis were not associated with cardio cerebral vascular complication when using cardio cerebral vascular complications as the dependent factor to do the Logistic regression analysis (P>0.05). (2) Primary disease, vascular access and the NT-proBNP levels are associated with survival in these patients (χ²=8.572, 5.911,Z=-4.447,-5.086;P<0.05 or 0.01). Logistic regression analysis showed that vascular access, the year of dialysis and the NT-proBNP levels associated with the risk of death in patients when using survival as the dependent factor (P<0.05 or 0.01). (3) Within half year, NT-proBNP increased less than 1 000ng/L has increased cerebrovascular complications and death rate compared with NT-proBNP increased more than 1 000ng/L, but no statistic significance (χ²=1.05,P>0.05). (4) Kaplan-Meier survival analysis showed that NT-proBNP more than 5 000ng/L of patients with an shorter survival time than NT-proBNP lower than 5 000ng/L (χ²=9.964,P<0.05).

The level of NT-proBNP in maintenance hemodialysis patients was increased. The increased NT-proBNP was associated with the risk of cardio cerebral vascular complications and death in hemodialysis patients.