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中华老年病研究电子杂志 ›› 2025, Vol. 12 ›› Issue (02) : 44 -48. doi: 10.3877/cma.j.issn.2095-8757.2025.02.008

综述

心外膜脂肪与心血管疾病关系的研究进展
张杰, 曹剑()   
  1. 100853 北京,解放军总医院第二医学中心保健四科 国家老年疾病临床医学研究中心
  • 收稿日期:2025-02-24 出版日期:2025-05-28
  • 通信作者: 曹剑

Relationship between epicardial adipose tissue and cardiovascular disease

Jie Zhang, Jian Cao()   

  1. The 4th Healthcare Department of the Second Medical Center, Chinese PLA General Hospital, National Clinical Research Center for Geriatric diseases, Beijing 100853, China
  • Received:2025-02-24 Published:2025-05-28
  • Corresponding author: Jian Cao
引用本文:

张杰, 曹剑. 心外膜脂肪与心血管疾病关系的研究进展[J/OL]. 中华老年病研究电子杂志, 2025, 12(02): 44-48.

Jie Zhang, Jian Cao. Relationship between epicardial adipose tissue and cardiovascular disease[J/OL]. Chinese Journal of Geriatrics Research(Electronic Edition), 2025, 12(02): 44-48.

心外膜脂肪(EAT)是位于心肌和心外膜之间的脂肪组织,与心肌之间不存在肌筋膜,可通过微循环相互影响,其病理生理功能在心血管疾病方面所起到的作用引起临床广泛关注。EAT既可通过摄取脂肪酸、分泌抗炎因子对邻近心肌产生保护作用,也可通过分泌炎性因子、脂肪酸浸润等途径诱发心血管疾病,对EAT的检测可对心血管疾病进行早期诊断和风险评估,同时EAT也是一个富有潜力的治疗靶点,临床或可通过改善EAT质量和功能来治疗心血管疾病。此文从EAT的生理学基础、病理生理转化机制、EAT在心血管疾病中的作用、EAT评估和靶向EAT治疗心血管疾病的方法等方面的研究进行梳理,以期系统展示EAT在心血管疾病防治中的可能作用。

Epicardial adipose tissue (EAT) is the adipose tissue located between the myocardium and the visceral layer of the epicardium. There is no muscular fascia between it and the myocardium, allowing for mutual influence through microcirculation. Its pathophysiological function in cardiovascular diseases has attracted widespread clinical attention. EAT can exert protective effects on adjacent myocardium either by uptaking fatty acids and secreting anti-inflammatory factors, or conversely, contribute to cardiovascular diseases by secreting inflammatory factors and through fatty acid infiltration. Detection of EAT can enable early diagnosis and risk assessment of cardiovascular diseases. Furthermore, EAT represents a promising therapeutic target; Clinically, improving the quality and function of EAT may offer a strategy for treating cardiovascular diseases. This article reviews current research on the physiological basis of EAT, the mechanisms underlying its transition from physiological to pathological functions, its role in cardiovascular diseases, methods for assessing EAT, and approaches for targeting EAT to treat cardiovascular diseases, with the aim of systematically illustrating the potential role of EAT in the prevention and treatment of cardiovascular diseases.

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