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中华老年病研究电子杂志 ›› 2025, Vol. 12 ›› Issue (02) : 37 -43. doi: 10.3877/cma.j.issn.2095-8757.2025.02.007

综述

布西珠单抗治疗老年糖尿病视网膜病变研究进展
张阳洋, 高艳虹()   
  1. 200438 上海市杨浦区殷行社区卫生服务中心;200092 上海,上海交通大学附属新华医院
  • 收稿日期:2025-02-25 出版日期:2025-05-28
  • 通信作者: 高艳虹
  • 基金资助:
    上海市中西医结合学会专项基金项目(2023SQ43)

Research progress on brolucizumab in the treatment of elderly diabetic retinopathy

Yangyang Zhang, Yanhong Gao()   

  1. Yinhang Community Health Center, Yangpu District, Shanghai 200438, China; Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Received:2025-02-25 Published:2025-05-28
  • Corresponding author: Yanhong Gao
引用本文:

张阳洋, 高艳虹. 布西珠单抗治疗老年糖尿病视网膜病变研究进展[J/OL]. 中华老年病研究电子杂志, 2025, 12(02): 37-43.

Yangyang Zhang, Yanhong Gao. Research progress on brolucizumab in the treatment of elderly diabetic retinopathy[J/OL]. Chinese Journal of Geriatrics Research(Electronic Edition), 2025, 12(02): 37-43.

糖尿病视网膜病变(DR)是由高血糖导致的视网膜微血管损害引起的常见并发症之一,以视力下降为主要表现,严重者可致失明。目前,玻璃体注射抗血管内皮生长因子(VEGF)类药物是治疗DR和糖尿病黄斑水肿(DME)的一线方案。布西珠单抗是靶向VEGF-A的单克隆抗体,它属于单链抗体片段,具有分子量更低、组织渗透性更强及免疫原性风险更低的优势。临床研究表明,布西珠单抗在改善视力、延缓疾病进展等方面的效果优于或不劣于阿柏西普、雷珠单抗等药物和全视网膜激光光凝(PRP)等治疗手段,且总体安全性较好,严重不良反应发生率较低。现就布西珠单抗治疗DR的最新进展作一综述,旨在为临床提供参考。

Diabetic retinopathy (DR) is one of the common microvascular complications of diabetes, caused by retinal microvascular damage induced by chronic hyperglycemia. It is a chronic progressive disease characterized by vision loss and can lead to severe consequences such as blindness in severe cases. Currently, intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) agents have become the first-line treatment for DR and diabetic macular edema (DME). Brolucizumab, a single-chain antibody fragment targeting VEGF-A, offers advantages such as a lower molecular weight, enhanced tissue permeability, and reduced immunogenicity risk. Clinical studies have shown that brolucizumab demonstrates superior or non-inferior efficacy compared to aflibercept, ranibizumab, and panretinal laser photocoagulation (PRP) in improving visual acuity and delaying disease progression, while also exhibiting a favorable safety profile with a lower incidence of severe adverse reactions. This review summarizes the latest advancements in the application of brolucizumab for the treatment of DR.

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