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中华老年病研究电子杂志

中华老年病研究电子杂志 ›› 2020, Vol. 07 ›› Issue (04) : 36 -39. doi: 10.3877/cma.j.issn.2095-8757.2020.04.007

所属专题： 文献；

临床研究

红景天白头翁丸治疗老年颈动脉粥样硬化斑块疗效分析
刘明勇1, 任昶2, 周立春1,†()   
  1. 1. 100043　首都医科大学附属北京朝阳医院西区神经内科
    2. 100043　首都医科大学附属北京朝阳医院西区中医科
  • 收稿日期:2020-05-20 出版日期:2020-11-28
  • 通信作者: 周立春

Clinical curative effect of rhodiola pulsatilla pills in treating carotid artery atherosclerotic plaque in the elderly

Mingyong Liu1, Chang Ren2, Lichun Zhou1,†()   

  1. 1. Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, China
    2. Department of Traditional Chinese Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, China
  • Received:2020-05-20 Published:2020-11-28
  • Corresponding author: Lichun Zhou
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刘明勇, 任昶, 周立春. 红景天白头翁丸治疗老年颈动脉粥样硬化斑块疗效分析[J]. 中华老年病研究电子杂志, 2020, 07(04): 36-39.

Mingyong Liu, Chang Ren, Lichun Zhou. Clinical curative effect of rhodiola pulsatilla pills in treating carotid artery atherosclerotic plaque in the elderly[J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2020, 07(04): 36-39.

目的

观察红景天白头翁丸治疗老年颈动脉粥样硬化（carotid artery atherosclerotic, CAS）斑块的疗效。

方法

选取2016年11月至2017年10月首都医科大学附属北京朝阳医院收治的老年CAS患者102例，其中对照组62例，采用常规抗血小板、降脂、降压、降糖等治疗；观察组60例，在对照组治疗基础上加用红景天白头翁丸（2次/d，2丸/次，6 g/丸）。两组患者治疗前及治疗后6个月均完成双侧颈动脉超声、血尿常规、血生化及心电图等检查。以最厚的颈总动脉或颈内动脉斑块作为目标斑块，比较其治疗前后的厚度变化。两组间正态与非正态分布计量资料分别采用t检验及秩和检验，计数资料的比较采用χ2检验。

结果

两组均无失访患者。随访结束时，两组患者血常规、尿常规及心电图均未发生明显变化；观察组患者目标斑块厚度降低中位数为0.55 mm，降低百分比中位数为14.5%；对照组患者目标斑块厚度降低中位数为0.05 mm，降低百分比中位数为2.5%；两组患者目标斑块降低厚度及降低百分比的差异均有统计学意义（P<0.05）。

结论

红景天白头翁丸能够缩小老年CAS斑块，具有一定的治疗效果。

关键词: 红景天, 白头翁, 动脉粥样硬化斑块, 超声检查
Objective

To observe the effect of rhodiola bungeana pill in the treatment of carotid atherosclerotic (CAS) plaque in the elderly.

Methods

102 elderly patients with CAS admitted to Beijing Chaoyang Hospital from November 2016 to October 2017 were selected. There were 62 patients in the control group, who were treated with conventional antiplatelet, lipid-lowering, antihypertensive and hypoglycemic therapy. There were 60 patients in the observation group, who were treated with rhodiola bungeana pill (2 times/d, 2 pills/time, 6 g/pill). Bilateral carotid ultrasound, blood and urine routine, blood biochemistry and electrocardiogram were performed before and 6 months after treatment in both groups. The thickest common carotid artery or internal carotid artery plaque was taken as the target plaque, and the thickness changes before and after treatment were compared. T test was used to compare the normal distribution measurement data, the rank test was used to compare the phenanthrene normal distribution measurement data, and the χ2 test was used to compare the counting data.

Results

There were no lost patients in both groups. At the end of the follow-up, there were no significant changes in blood routine, urine routine and electrocardiogram between the two groups. In the observation group, the median reduction of target plaque thickness was 0.55 mm, the median decrease of percentage was 14.5%; in the control group, the median reduction of target plaque thickness was 0.05 mm, the median decrease of percentage was 2.5%; there were significant differences in the thickness and decrease of percentage of target plaque between the two groups (P < 0.05). Rhodiola bungeana pill has a certain therapeutic effect and can reduce the plaque of CAS in the elderly.

Key words: Rhodiola, Bungeana, Carotid atherosclerotic plaque, Ultrasound
表1 两组患者一般资料的比较
组别 例数 性别（男/女，例） 年龄（岁） 高血压[例(%)] 高脂血症[例(%)] 糖尿病[例(%)] 目标斑块厚度（mm）
观察组 60 32/28 69.5±4.0 41（68.3） 58（96.7） 21（35.0） 2.9±0.7
对照组 62 34/28 69.0±3.5 40（64.5） 59（95.2） 24（38.7） 2.9±0.9
检验值   χ2=0.028 t=1.980 χ2=0.199 - χ2=0.180 t=1.582
P值   >0.05 >0.05 >0.05 >0.05 >0.05 >0.05
组别 例数 目标斑块稳定[例(%)] 既往脑梗死[例(%)] 既往TIA[例(%)] NIHSS评分 随访时间（月）
观察组 60 15（25.0） 34（56.7） 26（43.3） 0 6.0±0.1
对照组 62 16（25.8） 35（56.4） 27（43.6） 0 6.0±0.1
检验值   χ2=0.010 χ2=0.001 χ2=0.001 - t=1.658
P值   >0.05 >0.05 >0.05 - >0.05
图1 两组患者目标斑块厚度变化的比较
图2 两组患者目标斑块厚度变化百分比的比较
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