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中华老年病研究电子杂志 ›› 2018, Vol. 05 ›› Issue (04) : 46 -48. doi: 10.3877/cma.j.issn.2095-8757.2018.04.011

所属专题: 文献

综述

端粒与衰老及特发性肺纤维化的相关性研究
郭娜娜1, 刘学军2,(), 杜毓锋2, 钱力2, 郝小燕2, 刘丽芳2   
  1. 1. 030000 太原,山西医科大学
    2. 030001 太原,山西医科大学第一医院老年病科
  • 收稿日期:2018-02-01 出版日期:2018-11-28
  • 通信作者: 刘学军
  • 基金资助:
    山西省应用基础研究项目青年科技研究基金面上青年基金项目(201701D221272)

Correlation between telomere and senescence and idiopathic pulmonary fibrosis

Nana Guo1, Xuejun Liu2,(), Yufeng Du2, Li Qian2, Xiaoyan Hao2, Lifang Liu2   

  1. 1. Shanxi Medical University, Taiyuan 030000, China
    2. Department of Geriatrics, the First Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2018-02-01 Published:2018-11-28
  • Corresponding author: Xuejun Liu
  • About author:
    Corresponding author: Liu Xuejun, Email:
引用本文:

郭娜娜, 刘学军, 杜毓锋, 钱力, 郝小燕, 刘丽芳. 端粒与衰老及特发性肺纤维化的相关性研究[J/OL]. 中华老年病研究电子杂志, 2018, 05(04): 46-48.

Nana Guo, Xuejun Liu, Yufeng Du, Li Qian, Xiaoyan Hao, Lifang Liu. Correlation between telomere and senescence and idiopathic pulmonary fibrosis[J/OL]. Chinese Journal of Geriatrics Research(Electronic Edition), 2018, 05(04): 46-48.

随着老龄化社会的到来,与衰老相关慢性病的发病率呈增长趋势,衰老性疾病已引起国内外多学者的广泛关注。特发性肺纤维化是一种细胞复制性衰老疾病,易受年龄的影响。端粒、端粒酶已被证实为导致衰老的重要机制之一,其在肺部衰老和疾病的发生、发展过程中起着重要作用。进一步研究了解端粒与衰老及特发性肺纤维化的关系,将有助于临床治疗方案的选择,为提高疾病转归提供理论依据。

With the advent of an aging society, the incidence of chronic diseases associated with aging is on the rise, and aging diseases have attracted widespread attention from many scholars at home and abroad. Idiopathic pulmonary fibrosis is a cell-replicating aging disease that is susceptible to age. Telomere and telomerase have been identified as one of the important mechanisms leading to aging, which plays an important role in the development and progression of lung aging and disease. Further research to understand the relationship between telomere and aging and idiopathic pulmonary fibrosis will contribute to the choice of clinical treatment options and provide a theoretical basis for improving disease outcome.

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