| [1] | 
																						 
											  Urwin M, Symmons D, Allison T, et al. Estimating the burden of musculoskeletal disorders in the community: The comparative prevalence of symptoms at different anatomical sites, and the relation to social deprivation[J]. Ann Rheum Dis, 1998,57(11):649-655. 
											 											 | 
										
																													
																						| [2] | 
																						 
											  Chard MD, Hazleman R, Hazleman BL, et al. Shoulder disorders in the elderly: A community survey[J]. Arthritis Rheum, 1991,34(6):766-769. 
											 											 | 
										
																													
																						| [3] | 
																						 
											  Chard MD, Hazleman BL. Shoulder disorders in the elderly (a hospital study)[J]. Ann Rheum Dis, 1987, 46(9):684-687. 
											 											 | 
										
																													
																						| [4] | 
																						 
											  Gabel GT. Acute and chronic tendinopathies at the elbow[J]. Curr Opin Rheumatol, 1999, 11(2):138-143. 
											 											 | 
										
																													
																						| [5] | 
																						 
											  Jarvinen TA, Kannus P, Maffulli N, et al. Achilles tendon disorders: Etiology and epidemiology[J]. Foot Ankle Clin, 2005,10(2):255-266. 
											 											 | 
										
																													
																						| [6] | 
																						 
											  Teunis T, Lubberts B, Reilly T, et al. A systematic review and pooled analysis of the prevalence of rotator cuff disease with increasing age[J]. J Shoulder Elbow Surg, 2014, 23(12):1913-1921. 
											 											 | 
										
																													
																						| [7] | 
																						 
											  Korcari A, Przybelski SJ, Gingery A, et al. Impact of aging on tendon homeostasis, tendinopathy development, and impaired healing[J]. Connect Tissue Res, 2023, 64(1):1-13. 
											 											 | 
										
																													
																						| [8] | 
																						 
											  Lavagnino M, Gardner K, Arnoczky SP. Age-related changes in the cellular, mechanical, and contractile properties of rat tail tendons[J]. Connect Tissue Res, 2013, 54(1):70-75. 
											 											 | 
										
																													
																						| [9] | 
																						 
											  Arnesen SM, Lawson MA. Age-related changes in focal adhesions lead to altered cell behavior in tendon fibroblasts[J]. Mech Ageing Dev, 2006, 127(9):726-732. 
											 											 | 
										
																													
																						| [10] | 
																						 
											  Chang HN, Pang JH, Chen CP, et al. The effect of aging on migration, proliferation, and collagen expression of tenocytes in response to ciprofloxacin[J]. J Orthop Res, 2012, 30(5):764-768. 
											 											 | 
										
																													
																						| [11] | 
																						 
											  Tsai WC, Chang HN, Yu TY, et al. Decreased proliferation of aging tenocytes is associated with down-regulation of cellular senescence-inhibited gene and up-regulation of p27[J]. J Orthop Res, 2011, 29(10):1598-1603. 
											 											 | 
										
																													
																						| [12] | 
																						 
											  Dunkman AA, Buckley MR, Mienaltowski MJ, et al. Decorin expression is important for age-related changes in tendon structure and mechanical properties[J]. Matrix Biol, 2013, 32(1):3-13. 
											 											 | 
										
																													
																						| [13] | 
																						 
											  Barani AE, Durieux AC, Sabido O, et al. Age-related changes in the mitotic and metabolic characteristics of muscle-derived cells[J]. J Appl Physiol (1985), 2003, 95(5):2089-2098. 
											 											 | 
										
																													
																						| [14] | 
																						 
											  Klatte-Schulz F, Pauly S, Scheibel M, et al. Influence of age on the cell biological characteristics and the stimulation potential of male human tenocyte-like cells[J]. Eur Cell Mater, 2012, 24:74-89. 
											 											 | 
										
																													
																						| [15] | 
																						 
											  Zhang J, Wang JH. Mechanobiological response of tendon stem cells: Implications of tendon homeostasis and pathogenesis of tendinopathy[J]. J Orthop Res, 2010, 28(5):639-643. 
											 											 | 
										
																													
																						| [16] | 
																						 
											  Zhou Z, Akinbiyi T, Xu L, et al. Tendon-derived stem/progenitor cell aging: Defective self-renewal and altered fate[J]. Aging Cell,2010, 9(5):911-915. 
											 											 | 
										
																													
																						| [17] | 
																						 
											  Kjaer M. Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading[J]. Physiol Rev, 2004,84(2):649-698. 
											 											 | 
										
																													
																						| [18] | 
																						 
											  Birk DE, Trelstad RL. Extracellular compartments in tendon morphogenesis: Collagen fibril, bundle, and macroaggregate formation[J]. J Cell Biol, 1986, 103(1):231-240. 
											 											 | 
										
																													
																						| [19] | 
																						 
											  Kannus P. Structure of the tendon connective tissue[J]. Scand J Med Sci Sports, 2000, 10(6):312-320. 
											 											 | 
										
																													
																						| [20] | 
																						 
											  Docheva D, Muller SA, Majewski M, et al. Biologics for tendon repair[J]. Adv Drug Deliv Rev, 2015, 84:222-239. 
											 											 | 
										
																													
																						| [21] | 
																						 
											  Torricelli P, Veronesi F, Pagani S, et al. In vitro tenocyte metabolism in aging and oestrogen deficiency[J]. Age (Dordr),2013, 35(6):2125-2136. 
											 											 | 
										
																													
																						| [22] | 
																						 
											  Freedman BR, Knecht RS, Tinguely Y, et al. Aging and matrix viscoelasticity affect multiscale tendon properties and tendon derived cell behavior[J]. Acta Biomater, 2022, 143:63-71. 
											 											 | 
										
																													
																						| [23] | 
																						 
											  Nagy IZ, Von Hahn HP, Verzar F. Age-related alterations in the cell nuclei and the DNA content of rat tail tendon[J]. Gerontologia,1969, 15(4):258-264. 
											 											 | 
										
																													
																						| [24] | 
																						 
											  Sugiyama Y, Naito K, Goto K, et al. Effect of aging on the tendon structure and tendon-associated gene expression in mouse foot flexor tendon[J]. Biomed Rep, 2019, 10(4):238-244. 
											 											 | 
										
																													
																						| [25] | 
																						 
											  Korcari A, Nichols AEC, Loiselle AE. Depletion of scleraxislineage cells accelerates tendon ECM aging and retains remodeling tenocytes that enhance tendon healing[J]. BioArxiv, 2022. 
											 											 | 
										
																													
																						| [26] | 
																						 
											  Connizzo BK, Piet JM, Shefelbine SJ, et al. Age-associated changes in the response of tendon explants to stress deprivation is sex-dependent[J]. Connect Tissue Res, 2020, 61(1):48-62. 
											 											 | 
										
																													
																						| [27] | 
																						 
											  Stanley RL, Fleck RA, Becker DL, et al. Gap junction protein expression and cellularity: Comparison of immature and adult equine digital tendons[J]. J Anat, 2007, 211(3):325-334. 
											 											 | 
										
																													
																						| [28] | 
																						 
											  Thorpe CT, Mcdermott BT, Goodship AE, et al. Ageing does not result in a decline in cell synthetic activity in an injury prone tendon[J]. Scand J Med Sci Sports, 2016, 26(6):684-693. 
											 											 | 
										
																													
																						| [29] | 
																						 
											  Alexander RM. Tendon elasticity and muscle function[J]. Comp Biochem Physiol A Mol Integr Physiol, 2002, 133(4):1001-1011. 
											 											 | 
										
																													
																						| [30] | 
																						 
											  Bi Y, Ehirchiou D, Kilts TM, et al. Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche[J]. Nat Med, 2007, 13(10):1219-1227. 
											 											 | 
										
																													
																						| [31] | 
																						 
											  Rui YF, Lui PP, Li G, et al. Isolation and characterization of multipotent rat tendon-derived stem cells[J]. Tissue Eng Part A,2010, 16(5):1549-1558. 
											 											 | 
										
																													
																						| [32] | 
																						 
											  Zhang J, Wang JH. Moderate exercise mitigates the detrimental effects of aging on tendon stem cells[J/OL]. PLoS One, 2015,10(6):e0130454. 
											 											 | 
										
																													
																						| [33] | 
																						 
											  Wu H, Zhao G, Zu H, et al. Aging-related viscoelasticity variation of tendon stem cells (TSCs) characterized by quartz thickness shear mode (TSM) resonators[J]. Sens Actuators (Warrendale Pa),2015, 210:369-380. 
											 											 | 
										
																													
																						| [34] | 
																						 
											  Gehwolf R, Wagner A, Lehner C, et al. Pleiotropic roles of the matricellular protein Sparc in tendon maturation and ageing[J]. Sci Rep, 2016, 6:32635. 
											 											 | 
										
																													
																						| [35] | 
																						 
											  Jiang D, Xu B, Gao P. Effects of young extracellular matrix on the biological characteristics of aged tendon stem cells[J]. Adv Clin Exp Med, 2018, 27(12):1625-1630. 
											 											 | 
										
																													
																						| [36] | 
																						 
											  Kohler J, Popov C, Klotz B, et al. Uncovering the cellular and molecular changes in tendon stem/progenitor cells attributed to tendon aging and degeneration[J]. Aging Cell, 2013, 12(6):988-999. 
											 											 | 
										
																													
																						| [37] | 
																						 
											  Ruzzini L, Abbruzzese F, Rainer A, et al. Characterization of agerelated changes of tendon stem cells from adult human tendons[J].Knee Surg Sports Traumatol Arthrosc, 2014, 22(11):2856-2866. 
											 											 | 
										
																													
																						| [38] | 
																						 
											  Xu Y, Murrell GA. The basic science of tendinopathy[J]. Clin Orthop Relat Res, 2008, 466(7):1528-1538. 
											 											 | 
										
																													
																						| [39] | 
																						 
											  Riley G. The pathogenesis of tendinopathy. A molecular perspective[J]. Rheumatology (Oxford), 2004, 43(2):131-142. 
											 											 | 
										
																													
																						| [40] | 
																						 
											  Tsuzaki M, Yamauchi M, Banes AJ. Tendon collagens:Extracellular matrix composition in shear stress and tensile components of flexor tendons[J]. Connect Tissue Res, 1993,29(2):141-152. 
											 											 | 
										
																													
																						| [41] | 
																						 
											  Waggett AD, Ralphs JR, Kwan AP, et al. Characterization of collagens and proteoglycans at the insertion of the human Achilles tendon[J]. Matrix Biol, 1998, 16(8):457-470. 
											 											 | 
										
																													
																						| [42] | 
																						 
											  Stammers M, Ivanova IM, Niewczas IS, et al. Age-related changes in the physical properties, cross-linking, and glycation of collagen from mouse tail tendon[J]. J Biol Chem, 2020, 295(31):10562-10571. 
											 											 | 
										
																													
																						| [43] | 
																						 
											  Couppè C, Hansen P, Kongsgaard M, et al. Mechanical properties and collagen cross-linking of the patellar tendon in old and young men[J]. J Appl Physiol (1985), 2009, 107(3):880-886. 
											 											 | 
										
																													
																						| [44] | 
																						 
											  Haut RC, Lancaster RL, Decamp CE. Mechanical properties of the canine patellar tendon: Some correlations with age and the content of collagen[J]. J Biomech, 1992, 25(2):163-173. 
											 											 | 
										
																													
																						| [45] | 
																						 
											  Vogel HG. Influence of maturation and age on mechanical and biochemical parameters of connective tissue of various organs in the rat[J]. Connect Tissue Res, 1978, 6(3):161-166. 
											 											 | 
										
																													
																						| [46] | 
																						 
											  Kostrominova TY, Brooks SV. Age-related changes in structure and extracellular matrix protein expression levels in rat tendons[J].Age (Dordr), 2013, 35(6):2203-2214. 
											 											 | 
										
																													
																						| [47] | 
																						 
											  Birch HL, Bailey JV, Bailey AJ, et al. Age-related changes to the molecular and cellular components of equine flexor tendons[J].Equine Vet J, 1999, 31(5):391-396. 
											 											 | 
										
																													
																						| [48] | 
																						 
											  Thorpe CT, Streeter I, Pinchbeck GL, et al. Aspartic acid racemization and collagen degradation markers reveal an accumulation of damage in tendon collagen that is enhanced with aging[J]. J Biol Chem, 2010, 285(21):15674-15681. 
											 											 | 
										
																													
																						| [49] | 
																						 
											  Sharon N. IUPAC-IUB Joint Commission on Biochemical Nomenclature (JCBN). Nomenclature of glycoproteins,glycopeptides and peptidoglycans. Recommendations 1985[J]. Eur J Biochem, 1986, 159(1):1-6. 
											 											 | 
										
																													
																						| [50] | 
																						 
											  Thorpe CT, Birch HL, Clegg PD, et al. The role of the noncollagenous matrix in tendon function[J]. Int J Exp Pathol, 2013,94(4):248-259. 
											 											 | 
										
																													
																						| [51] | 
																						 
											  Ippolito E, Natali PG, Postacchini F, et al. Morphological,immunochemical, and biochemical study of rabbit achilles tendon at various ages[J]. J Bone Joint Surg Am, 1980, 62(4):583-598. 
											 											 | 
										
																													
																						| [52] | 
																						 
											  Clayton RA, Court-Brown CM. The epidemiology of musculoskeletal tendinous and ligamentous injuries[J]. Injury,2008, 39(12):1338-1344. 
											 											 | 
										
																													
																						| [53] | 
																						 
											  Hijioka A, Suzuki K, Nakamura T, et al. Degenerative change and rotator cuff tears. An anatomical study in 160 shoulders of 80 cadavers[J]. Arch Orthop Trauma Surg, 1993, 112(2):61-64. 
											 											 | 
										
																													
																						| [54] | 
																						 
											  Chard MD, Cawston TE, Riley GP, et al. Rotator cuff degeneration and lateral epicondylitis: A comparative histological study[J]. Ann Rheum Dis, 1994, 53(1):30-34. 
											 											 | 
										
																													
																						| [55] | 
																						 
											  Houshian S, Tscherning T, Riegels-Nielsen P. The epidemiology of Achilles tendon rupture in a Danish county[J]. Injury, 1998,29(9):651-654. 
											 											 | 
										
																													
																						| [56] | 
																						 
											  Hess GW. Achilles tendon rupture: A review of etiology,population, anatomy, risk factors, and injury prevention[J]. Foot Ankle Spec, 2010, 3(1):29-32. 
											 											 | 
										
																													
																						| [57] | 
																						 
											  Albers IS, Zwerver J, Diercks RL, et al. Incidence and prevalence of lower extremity tendinopathy in a Dutch general practice population: A cross sectional study[J]. BMC Musculoskelet Disord, 2016, 17:16. 
											 											 | 
										
																													
																						| [58] | 
																						 
											  Grosset JF, Breen L, Stewart CE, et al. Influence of exercise intensity on training-induced tendon mechanical properties changes in older individuals[J]. Age (Dordr), 2014, 36(3):9657. 
											 											 | 
										
																													
																						| [59] | 
																						 
											  Zhang J, Yuan T, Wang JH. Moderate treadmill running exercise prior to tendon injury enhances wound healing in aging rats[J].Oncotarget, 2016, 7(8):8498-8512. 
											 											 | 
										
																													
																						| [60] | 
																						 
											  Jiang D, Jiang Z, Zhang Y, et al. Effect of young extrinsic environment stimulated by hypoxia on the function of aged tendon stem cell[J]. Cell Biochem Biophys, 2014, 70(2):967-973. 
											 											 |