切换至 "中华医学电子期刊资源库"

中华老年病研究电子杂志 ›› 2024, Vol. 11 ›› Issue (03) : 38 -44. doi: 10.3877/cma.j.issn.2095-8757.2024.03.008

综述

衰老对肌腱的影响
于小鲁1, 钟章锋2, 邹德华2, 陈陟阳3, 王景浩4, 周平辉5, 王华军1,(), 郑小飞1   
  1. 1.510630 广州,暨南大学附属第一医院运动医学科 广州市精准骨科与再生医学重点实验室 广东省速度能力研究重点实验室
    2.999078 澳门科技大学中药质量研究国家重点实验室 澳门科技大学中医药学院
    3.510632 广州,暨南大学教育部再生医学重点实验室 衰老与再生医学研究院
    4.510630 广州,暨南大学附属第一医院药学部 寒地心血管病全国重点实验室 广州市慢病基础研究与转化重点实验室
    5.233030 蚌埠,蚌埠医科大学第一附属医院骨科 蚌埠医科大学组织移植安徽省重点实验室
  • 收稿日期:2024-06-07 出版日期:2024-08-28
  • 通信作者: 王华军
  • 基金资助:
    广州市科技计划项目(2024A03J0971、2023A03J0566、2023A03J1015、2024A04J4173、202201020566)国家自然科学基金项目(82074511、82374558、81973660)广东省医学科学技术研究基金项目(A2023143)暨南大学医学联合基金资金资助(YXJC2022005)暨南大学第一临床医学院临床研究项目(2018009)广东省速度能力研究重点实验室开放基金资助项目(2023B1212010009)

Effects of senescence on tendons

Xiaolu Yu1, Zhangfeng Zhong2, Dehua Zou2, Zhiyang Chen3, Jinghao Wang4, Pinghui Zhou5, Huajun Wang1,(), Xiaofei Zheng1   

  1. 1.Department of Sports Medicine, the First Affiliated Hospital of Ji'nan University, Guangzhou Key Laboratory of Precision Orthopedics and Regenerative Medicine, Guangdong Provincial Key Laboratory of Speed Capability Research, Guangzhou 510630, China
    2.State Key Laboratory of Quality Research in Traditional Chinese Medicines, Faculty of Chinese Medicine,Macau University of Science and Technology, 999078 Macau, China
    3.Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Ji'nan University,Guangzhou 510632, China
    4.Department of Pharmacy, the First Affiliated Hospital of Ji'nan University,State Key Laboratory of Frigid Zone Cardiovascular Diseases, Guangzhou Key Laboratory of Basic and Translational Research on Chronic Diseases, Guangzhou 510630, China
    5.Department of Orthopedics,the First Affiliated Hospital of Bengbu Medical University, Anhui Province Key Laboratory of Tissue Transplantation, Bengbu Medical University, Bengbu 233030, China
  • Received:2024-06-07 Published:2024-08-28
  • Corresponding author: Huajun Wang
引用本文:

于小鲁, 钟章锋, 邹德华, 陈陟阳, 王景浩, 周平辉, 王华军, 郑小飞. 衰老对肌腱的影响[J/OL]. 中华老年病研究电子杂志, 2024, 11(03): 38-44.

Xiaolu Yu, Zhangfeng Zhong, Dehua Zou, Zhiyang Chen, Jinghao Wang, Pinghui Zhou, Huajun Wang, Xiaofei Zheng. Effects of senescence on tendons[J/OL]. Chinese Journal of Geriatrics Research(Electronic Edition), 2024, 11(03): 38-44.

随着社会老龄化程度的不断加重,衰老对肌腱的影响备受关注。目前,衰老相关致病机制尚未完全阐明。本文总结了衰老对肌腱细胞、肌腱干细胞及细胞外基质等方面的影响,并探讨了衰老相关肩袖损伤、跟腱断裂等疾病的流行病学特征和衰老肌腱潜在的改善及治疗方法,旨在为进一步研究衰老肌腱相关病理生理机制、开发有效干预策略以及相关疾病治疗提供新思路。

As the aging population in China continues to increase, the effect of senescence on tendons has attracted much attention. At present, the pathogenic mechanisms of senescence have not been fully elucidated. This article summarizes the effects of senescence on tendon cells, tendon stem cells,and extracellular matrix, and discusses the epidemiological characteristics of senescence-related diseases such as rotator cuff injury and Achilles tendon rupture, as well as potential ameliorations and treatments for senescence tendons. The aim is to provide new ideas for further research into the pathological and physiological mechanisms of senescence tendons, the development of effective intervention strategies,and the treatment of related diseases.

[1]
Urwin M, Symmons D, Allison T, et al. Estimating the burden of musculoskeletal disorders in the community: The comparative prevalence of symptoms at different anatomical sites, and the relation to social deprivation[J]. Ann Rheum Dis, 1998,57(11):649-655.
[2]
Chard MD, Hazleman R, Hazleman BL, et al. Shoulder disorders in the elderly: A community survey[J]. Arthritis Rheum, 1991,34(6):766-769.
[3]
Chard MD, Hazleman BL. Shoulder disorders in the elderly (a hospital study)[J]. Ann Rheum Dis, 1987, 46(9):684-687.
[4]
Gabel GT. Acute and chronic tendinopathies at the elbow[J]. Curr Opin Rheumatol, 1999, 11(2):138-143.
[5]
Jarvinen TA, Kannus P, Maffulli N, et al. Achilles tendon disorders: Etiology and epidemiology[J]. Foot Ankle Clin, 2005,10(2):255-266.
[6]
Teunis T, Lubberts B, Reilly T, et al. A systematic review and pooled analysis of the prevalence of rotator cuff disease with increasing age[J]. J Shoulder Elbow Surg, 2014, 23(12):1913-1921.
[7]
Korcari A, Przybelski SJ, Gingery A, et al. Impact of aging on tendon homeostasis, tendinopathy development, and impaired healing[J]. Connect Tissue Res, 2023, 64(1):1-13.
[8]
Lavagnino M, Gardner K, Arnoczky SP. Age-related changes in the cellular, mechanical, and contractile properties of rat tail tendons[J]. Connect Tissue Res, 2013, 54(1):70-75.
[9]
Arnesen SM, Lawson MA. Age-related changes in focal adhesions lead to altered cell behavior in tendon fibroblasts[J]. Mech Ageing Dev, 2006, 127(9):726-732.
[10]
Chang HN, Pang JH, Chen CP, et al. The effect of aging on migration, proliferation, and collagen expression of tenocytes in response to ciprofloxacin[J]. J Orthop Res, 2012, 30(5):764-768.
[11]
Tsai WC, Chang HN, Yu TY, et al. Decreased proliferation of aging tenocytes is associated with down-regulation of cellular senescence-inhibited gene and up-regulation of p27[J]. J Orthop Res, 2011, 29(10):1598-1603.
[12]
Dunkman AA, Buckley MR, Mienaltowski MJ, et al. Decorin expression is important for age-related changes in tendon structure and mechanical properties[J]. Matrix Biol, 2013, 32(1):3-13.
[13]
Barani AE, Durieux AC, Sabido O, et al. Age-related changes in the mitotic and metabolic characteristics of muscle-derived cells[J]. J Appl Physiol (1985), 2003, 95(5):2089-2098.
[14]
Klatte-Schulz F, Pauly S, Scheibel M, et al. Influence of age on the cell biological characteristics and the stimulation potential of male human tenocyte-like cells[J]. Eur Cell Mater, 2012, 24:74-89.
[15]
Zhang J, Wang JH. Mechanobiological response of tendon stem cells: Implications of tendon homeostasis and pathogenesis of tendinopathy[J]. J Orthop Res, 2010, 28(5):639-643.
[16]
Zhou Z, Akinbiyi T, Xu L, et al. Tendon-derived stem/progenitor cell aging: Defective self-renewal and altered fate[J]. Aging Cell,2010, 9(5):911-915.
[17]
Kjaer M. Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading[J]. Physiol Rev, 2004,84(2):649-698.
[18]
Birk DE, Trelstad RL. Extracellular compartments in tendon morphogenesis: Collagen fibril, bundle, and macroaggregate formation[J]. J Cell Biol, 1986, 103(1):231-240.
[19]
Kannus P. Structure of the tendon connective tissue[J]. Scand J Med Sci Sports, 2000, 10(6):312-320.
[20]
Docheva D, Muller SA, Majewski M, et al. Biologics for tendon repair[J]. Adv Drug Deliv Rev, 2015, 84:222-239.
[21]
Torricelli P, Veronesi F, Pagani S, et al. In vitro tenocyte metabolism in aging and oestrogen deficiency[J]. Age (Dordr),2013, 35(6):2125-2136.
[22]
Freedman BR, Knecht RS, Tinguely Y, et al. Aging and matrix viscoelasticity affect multiscale tendon properties and tendon derived cell behavior[J]. Acta Biomater, 2022, 143:63-71.
[23]
Nagy IZ, Von Hahn HP, Verzar F. Age-related alterations in the cell nuclei and the DNA content of rat tail tendon[J]. Gerontologia,1969, 15(4):258-264.
[24]
Sugiyama Y, Naito K, Goto K, et al. Effect of aging on the tendon structure and tendon-associated gene expression in mouse foot flexor tendon[J]. Biomed Rep, 2019, 10(4):238-244.
[25]
Korcari A, Nichols AEC, Loiselle AE. Depletion of scleraxislineage cells accelerates tendon ECM aging and retains remodeling tenocytes that enhance tendon healing[J]. BioArxiv, 2022.
[26]
Connizzo BK, Piet JM, Shefelbine SJ, et al. Age-associated changes in the response of tendon explants to stress deprivation is sex-dependent[J]. Connect Tissue Res, 2020, 61(1):48-62.
[27]
Stanley RL, Fleck RA, Becker DL, et al. Gap junction protein expression and cellularity: Comparison of immature and adult equine digital tendons[J]. J Anat, 2007, 211(3):325-334.
[28]
Thorpe CT, Mcdermott BT, Goodship AE, et al. Ageing does not result in a decline in cell synthetic activity in an injury prone tendon[J]. Scand J Med Sci Sports, 2016, 26(6):684-693.
[29]
Alexander RM. Tendon elasticity and muscle function[J]. Comp Biochem Physiol A Mol Integr Physiol, 2002, 133(4):1001-1011.
[30]
Bi Y, Ehirchiou D, Kilts TM, et al. Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche[J]. Nat Med, 2007, 13(10):1219-1227.
[31]
Rui YF, Lui PP, Li G, et al. Isolation and characterization of multipotent rat tendon-derived stem cells[J]. Tissue Eng Part A,2010, 16(5):1549-1558.
[32]
Zhang J, Wang JH. Moderate exercise mitigates the detrimental effects of aging on tendon stem cells[J/OL]. PLoS One, 2015,10(6):e0130454.
[33]
Wu H, Zhao G, Zu H, et al. Aging-related viscoelasticity variation of tendon stem cells (TSCs) characterized by quartz thickness shear mode (TSM) resonators[J]. Sens Actuators (Warrendale Pa),2015, 210:369-380.
[34]
Gehwolf R, Wagner A, Lehner C, et al. Pleiotropic roles of the matricellular protein Sparc in tendon maturation and ageing[J]. Sci Rep, 2016, 6:32635.
[35]
Jiang D, Xu B, Gao P. Effects of young extracellular matrix on the biological characteristics of aged tendon stem cells[J]. Adv Clin Exp Med, 2018, 27(12):1625-1630.
[36]
Kohler J, Popov C, Klotz B, et al. Uncovering the cellular and molecular changes in tendon stem/progenitor cells attributed to tendon aging and degeneration[J]. Aging Cell, 2013, 12(6):988-999.
[37]
Ruzzini L, Abbruzzese F, Rainer A, et al. Characterization of agerelated changes of tendon stem cells from adult human tendons[J].Knee Surg Sports Traumatol Arthrosc, 2014, 22(11):2856-2866.
[38]
Xu Y, Murrell GA. The basic science of tendinopathy[J]. Clin Orthop Relat Res, 2008, 466(7):1528-1538.
[39]
Riley G. The pathogenesis of tendinopathy. A molecular perspective[J]. Rheumatology (Oxford), 2004, 43(2):131-142.
[40]
Tsuzaki M, Yamauchi M, Banes AJ. Tendon collagens:Extracellular matrix composition in shear stress and tensile components of flexor tendons[J]. Connect Tissue Res, 1993,29(2):141-152.
[41]
Waggett AD, Ralphs JR, Kwan AP, et al. Characterization of collagens and proteoglycans at the insertion of the human Achilles tendon[J]. Matrix Biol, 1998, 16(8):457-470.
[42]
Stammers M, Ivanova IM, Niewczas IS, et al. Age-related changes in the physical properties, cross-linking, and glycation of collagen from mouse tail tendon[J]. J Biol Chem, 2020, 295(31):10562-10571.
[43]
Couppè C, Hansen P, Kongsgaard M, et al. Mechanical properties and collagen cross-linking of the patellar tendon in old and young men[J]. J Appl Physiol (1985), 2009, 107(3):880-886.
[44]
Haut RC, Lancaster RL, Decamp CE. Mechanical properties of the canine patellar tendon: Some correlations with age and the content of collagen[J]. J Biomech, 1992, 25(2):163-173.
[45]
Vogel HG. Influence of maturation and age on mechanical and biochemical parameters of connective tissue of various organs in the rat[J]. Connect Tissue Res, 1978, 6(3):161-166.
[46]
Kostrominova TY, Brooks SV. Age-related changes in structure and extracellular matrix protein expression levels in rat tendons[J].Age (Dordr), 2013, 35(6):2203-2214.
[47]
Birch HL, Bailey JV, Bailey AJ, et al. Age-related changes to the molecular and cellular components of equine flexor tendons[J].Equine Vet J, 1999, 31(5):391-396.
[48]
Thorpe CT, Streeter I, Pinchbeck GL, et al. Aspartic acid racemization and collagen degradation markers reveal an accumulation of damage in tendon collagen that is enhanced with aging[J]. J Biol Chem, 2010, 285(21):15674-15681.
[49]
Sharon N. IUPAC-IUB Joint Commission on Biochemical Nomenclature (JCBN). Nomenclature of glycoproteins,glycopeptides and peptidoglycans. Recommendations 1985[J]. Eur J Biochem, 1986, 159(1):1-6.
[50]
Thorpe CT, Birch HL, Clegg PD, et al. The role of the noncollagenous matrix in tendon function[J]. Int J Exp Pathol, 2013,94(4):248-259.
[51]
Ippolito E, Natali PG, Postacchini F, et al. Morphological,immunochemical, and biochemical study of rabbit achilles tendon at various ages[J]. J Bone Joint Surg Am, 1980, 62(4):583-598.
[52]
Clayton RA, Court-Brown CM. The epidemiology of musculoskeletal tendinous and ligamentous injuries[J]. Injury,2008, 39(12):1338-1344.
[53]
Hijioka A, Suzuki K, Nakamura T, et al. Degenerative change and rotator cuff tears. An anatomical study in 160 shoulders of 80 cadavers[J]. Arch Orthop Trauma Surg, 1993, 112(2):61-64.
[54]
Chard MD, Cawston TE, Riley GP, et al. Rotator cuff degeneration and lateral epicondylitis: A comparative histological study[J]. Ann Rheum Dis, 1994, 53(1):30-34.
[55]
Houshian S, Tscherning T, Riegels-Nielsen P. The epidemiology of Achilles tendon rupture in a Danish county[J]. Injury, 1998,29(9):651-654.
[56]
Hess GW. Achilles tendon rupture: A review of etiology,population, anatomy, risk factors, and injury prevention[J]. Foot Ankle Spec, 2010, 3(1):29-32.
[57]
Albers IS, Zwerver J, Diercks RL, et al. Incidence and prevalence of lower extremity tendinopathy in a Dutch general practice population: A cross sectional study[J]. BMC Musculoskelet Disord, 2016, 17:16.
[58]
Grosset JF, Breen L, Stewart CE, et al. Influence of exercise intensity on training-induced tendon mechanical properties changes in older individuals[J]. Age (Dordr), 2014, 36(3):9657.
[59]
Zhang J, Yuan T, Wang JH. Moderate treadmill running exercise prior to tendon injury enhances wound healing in aging rats[J].Oncotarget, 2016, 7(8):8498-8512.
[60]
Jiang D, Jiang Z, Zhang Y, et al. Effect of young extrinsic environment stimulated by hypoxia on the function of aged tendon stem cell[J]. Cell Biochem Biophys, 2014, 70(2):967-973.
[1] 何甘霖, 陈香侬, 李萍, 甄佳怡, 李京霞, 邹外一, 许多荣. 白血病异基因造血干细胞移植术后股骨坏死的影响因素[J/OL]. 中华关节外科杂志(电子版), 2024, 18(04): 450-456.
[2] 李友, 唐林峰, 杜伟伟, 刘海亮, 余新水, 沈佳宇, 巨积辉. 皮瓣联合掌长肌腱折叠单排三点式固定治疗指背侧创面伴锤状指畸形的临床效果观察[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(06): 485-490.
[3] 刘昌玲, 张金丽, 张志, 李孝建, 汤文彬, 胡逸萍, 陈宾, 谢晓娜. 负载人脂肪干细胞外泌体的甲基丙烯酰化明胶水凝胶对人皮肤成纤维细胞增殖和迁移的影响[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(06): 517-525.
[4] 雷子威, 凌萍, 沈纵, 魏晨如, 朱邦晖, 伍国胜, 孙瑜. 类器官肺损伤疾病模型构建及应用的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(06): 531-535.
[5] 宋勤琴, 李双汝, 李林, 杜鹃, 刘继松. 间充质干细胞源性外泌体在改善病理性瘢痕中作用的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(06): 550-553.
[6] 关丁丁, 李伟, 孔维诗, 包郁露, 孙瑜. 负载干细胞的光交联蛋白基水凝胶在组织工程中应用的研究进展[J/OL]. 中华损伤与修复杂志(电子版), 2024, 19(05): 447-452.
[7] 胡思平, 熊性宇, 徐航, 杨璐. 衰老相关分泌表型因子在前列腺癌发生发展中的作用机制[J/OL]. 中华腔镜泌尿外科杂志(电子版), 2024, 18(05): 425-434.
[8] 傅红兴, 王植楷, 谢贵林, 蔡娟娟, 杨威, 严盛. 间充质干细胞促进胰岛移植效果的研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(06): 351-360.
[9] 王大伟, 陆雅斐, 皇甫少华, 陈玉婷, 陈澳, 江滨. 间充质干细胞通过调控免疫机制促进创面愈合的研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(06): 361-366.
[10] 刘文竹, 唐窈, 刘付臣. 诱导多潜能干细胞在神经肌肉疾病研究中的应用进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(06): 367-373.
[11] 袁园园, 岳乐淇, 张华兴, 武艳, 李全海. 间充质干细胞在呼吸系统疾病模型中肺组织分布及治疗机制的研究进展[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(06): 374-381.
[12] 蔡艺丹, 方坚, 张志强, 陈莉, 张世安, 夏磊, 阮梅, 李东良. 经颈静脉肝内门体分流术对肝硬化门脉高压患者肠道菌群及肝功能的影响[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(05): 285-293.
[13] 王俊楠, 刘晔, 李若涵, 叶青松. 间充质干细胞调控肠脑轴治疗神经系统疾病的潜力[J/OL]. 中华细胞与干细胞杂志(电子版), 2024, 14(05): 313-319.
[14] 王向前, 李清峰, 陈磊, 丘文丹, 姚志成, 李熠, 吴荣焕. 姜黄素抑制肝细胞癌索拉非尼耐药作用及其调控机制[J/OL]. 中华肝脏外科手术学电子杂志, 2024, 13(05): 729-735.
[15] 谢志涛, 高小康, 王丽敏, 张净宇, 李文静, 高冰, 胡永成. 同种异体肌腱在运动系统常见损伤中的应用[J/OL]. 中华老年骨科与康复电子杂志, 2024, 10(04): 237-242.
阅读次数
全文


摘要