探讨老年综合评估（comprehensive geriatric assessment, CGA）指导下的综合干预措施对老年肌少症的治疗效果。

采用浙江医院研发的CGA软件进行评估，筛选出2018年6-12月原解放军第一一七医院（现联勤保障部队第九〇三医院）收治的老年肌少症患者120例。其中对照组（60例）患者仅治疗基础疾病，不给予肌少症干预措施；观察组在治疗基础疾病的同时根据CGA结果进行肌少症综合干预，包括运动疗法、营养疗法、药物治疗以及对生活、环境、用药、心理等进行管理。观察两组患者入组时、治疗3个月、治疗6个月的实验室检查（包括血白蛋白、血红蛋白、空腹血糖、胆固醇、甘油三酯以及钠、钾、钙等电解质）结果、人体成分（包括无机盐、蛋白质、体脂肪、BMI以及四肢肌量指数）分析结果和肌少症评估（包括步速、握力及日常生活能力）情况。计量资料的组间比较采用独立样本t检验，计数资料的比较采用χ²检验；两组患者连续性时点指标的比较采用重复测量方差分析。

两组患者白蛋白水平、蛋白质水平、四肢肌量指数及步速的差异均具有组间效应（F=3.783、4.038、61.114、124.119，均P<0.05），治疗3个月和治疗6个月时两组患者白蛋白水平、蛋白质水平、四肢肌量指数及步速的差异均有统计学意义（均P<0.05）；其他指标的差异均无组间效应（均P>0.05）。

CGA指导下的综合干预措施对老年肌少症的短期治疗是有效的，长期治疗效果尚有待证实。

To to explore the therapeutic effect of comprehensive intervention measures under the guidance of comprehensive geriatric assessment (CGA) on senil sarcopenia in the elderly.

120 elderly patients with sarcopenia who were admitted to No.93 Hospital of the Joint Logistic Support Force from June to December 2018 were evaluated by using CGA software developed by Zhejiang Hospital. The control group (60 cases) was only treated with basic diseases, without sarcopenia intervention measures;The observation group received comprehensive intervention for sarcopenia according to CGA results while treating basic diseases, including exercise therapy, nutrition therapy, drug therapy, and management of life, environment, medication and psychology. Before treatment, 3 months and 6 months after treatment, the results of laboratory examination (including serum albumin, hemoglobin, fasting blood glucose, cholesterol, triglyceride and electrolytes such as sodium, potassium and calcium), body composition (including inorganic salt, protein, body fat, BMI and muscle mass index of extremities) and assessment of sarcopenia (including walking speed, body fat, body fat and muscle mass index of extremities) were observed. T test was used to compare the measurement data between groups, and the χ² test was used to compare the enumeration data. Repeated measure analysis of variance was used to compare continuous time point indicators between the two groups.

The albumin level, protein level, limb muscle mass index and walking speed in two groups had inter-group effects (F=3.783, 4.038, 61.114, 124.119, P < 0.05), and there were statistically significant differences in albumin level, protein level, limb muscle mass index and walking speed between two groups after 3 months and 6 months of treatment (P < 0.05). There was no inter-group effect in other indicators (P > 0.05).

Comprehensive intervention measures under the guidance of CGA are effective in the short-term treatment of senile sarcopenia, but the long-term treatment effect remains to be confirmed.