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中华老年病研究电子杂志 ›› 2026, Vol. 13 ›› Issue (01) : 40 -46. doi: 10.3877/cma.j.issn.2095-8757.2026.01.007

综述

靶向细胞焦亡的阿尔茨海默病治疗策略研究进展
丁洪基, 孙阳燕, 王灿(), 王贵珍, 李龙龙   
  1. 257000 东营,山东大学齐鲁医院东营分院病理科
  • 收稿日期:2025-11-16 出版日期:2026-02-28
  • 通信作者: 王灿

Research progress on therapeutic strategies targeting pyroptosis for Alzheimer's disease

Hongji Ding, Yangyan Sun, Can Wang(), Guizhen Wang, Longlong Li   

  1. Department of Pathology, Qilu Hospital of Shandong University Dongying Branch, Dongying 257000, China
  • Received:2025-11-16 Published:2026-02-28
  • Corresponding author: Can Wang
引用本文:

丁洪基, 孙阳燕, 王灿, 王贵珍, 李龙龙. 靶向细胞焦亡的阿尔茨海默病治疗策略研究进展[J/OL]. 中华老年病研究电子杂志, 2026, 13(01): 40-46.

Hongji Ding, Yangyan Sun, Can Wang, Guizhen Wang, Longlong Li. Research progress on therapeutic strategies targeting pyroptosis for Alzheimer's disease[J/OL]. Chinese Journal of Geriatrics Research(Electronic Edition), 2026, 13(01): 40-46.

阿尔茨海默病(Alzheimer's disease, AD)是一种以记忆力丧失和认知障碍为特征的神经退行性疾病,其发病率高居前列。细胞焦亡是一种炎性程序性细胞死亡模式。β-淀粉样蛋白和Tau蛋白参与了细胞焦亡的发生,且在焦亡激活的途径中,炎性小体、促炎细胞因子与AD的发病有关。细胞焦亡可能是神经元死亡的重要形式之一,焦亡介导的神经炎症在AD的发病和发展过程中起着核心作用。抑制焦亡及其下游的炎症过程,可以减轻AD的相关病理变化,为临床提供了新的治疗靶点。

Alzheimer's disease (AD) is a neurodegenerative disease characterized by memory loss and cognitive impairment, which has the highest incidence in the world. Pyroptosis is an inflammatory programmed cell death pattern discovered in recent years. Studies have shown that AD is closely related to pyroptosis. It has been confirmed that amyloid-beta protein and Tau proteins are involved in the occurrence of pyroptosis, and inflammasome and pro-inflammatory cytokines are involved in the pathogenesis of AD in the pathway of pyroptosis activation. Pyroptosis may be the main form of neuronal death. Pyroptosis mediated neuroinflammation plays a central role in the pathogenesis and progression of AD. Inhibition of pyroptosis and downstream inflammatory processes can alleviate the related pathological changes of AD and provide a new clinical therapeutic target.

图1 阿尔茨海默病神经病理中的细胞焦亡途径示意图
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