切换至 "中华医学电子期刊资源库"

中华老年病研究电子杂志 ›› 2024, Vol. 11 ›› Issue (01) : 5 -10. doi: 10.3877/cma.j.issn.2095-8757.2024.01.002

衰弱综合征

炎症标志物与老年衰弱综合征
吴立1, 蒋婧瑾1,()   
  1. 1. 310003 杭州,浙江大学医学院附属第一医院老年医学科
  • 收稿日期:2023-11-08 出版日期:2024-02-28
  • 通信作者: 蒋婧瑾
  • 基金资助:
    国家重点研发计划项目(2020YFC2008900)

Inflammatory markers and frailty in the elderly

Li Wu1, Jingjin Jiang1,()   

  1. 1. Department of Geriatics, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
  • Received:2023-11-08 Published:2024-02-28
  • Corresponding author: Jingjin Jiang
引用本文:

吴立, 蒋婧瑾. 炎症标志物与老年衰弱综合征[J]. 中华老年病研究电子杂志, 2024, 11(01): 5-10.

Li Wu, Jingjin Jiang. Inflammatory markers and frailty in the elderly[J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2024, 11(01): 5-10.

老年衰弱综合征是老年人群常见的致残性因素,机体的炎症过程与老年衰弱之间存在密切联系。近年来,研究人员对炎症标志物在老年衰弱综合征中的作用进行了广泛的研究,这些标志物包括细胞因子、白细胞、氧化应激指标、C反应蛋白、肿瘤坏死因子等。本文回顾目前关于炎症标志物与老年衰弱综合征的研究成果,分析它们在诊断、预测和干预老年衰弱综合征方面的潜在应用价值,以便于临床筛选老年衰弱综合征的干预靶点,促进更有效的预防和管理策略,从而提升老年人群的健康和生活质量。

Geriatric frailty syndrome is a common debilitating condition among the elderly population, which is closely associated with systemic inflammation processes. In recent years, researchers have extensively studied the role of inflammatory biomarkers in geriatric frailty, including cytokines, white blood cells, oxidative stress indicators, C-reactive protein, tumor necrosis factor, etc. This paper aims to review the current research findings on the relationship between inflammatory biomarkers and geriatric frailty syndrome, analyzing their potential value in diagnosis, prediction, and intervention of frailty in the elderly, facilitating the development of more effective strategies for prevention and management, ultimately improving the health and quality of life of the elderly.

[1]
Franceschi C, Bonafè M, Valensin S, et al. Inflamm-aging. An evolutionary perspective on immunosenescence[J]. Ann N Y Acad Sci, 2000, 908:244-254.
[2]
Sayed N, Huang Y, Nguyen K, et al. An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging[J]. Nat Aging, 2021, 1:598-615.
[3]
Gómez-Rubio P, Trapero I, Cauli O, et al. Salivary IL-6 concentration is associated with frailty syndrome in older individuals[J]. Diagnostics (Basel), 2022, 12(1):117.
[4]
Tembo MC, Holloway-Kew KL, Bortolasci CC, et al. Association between serum interleukin-6 and frailty in older men: cross-sectional data[J]. Eur Geriatr Med, 2021, 12(4):887-892.
[5]
Samson LD, Buisman AM, Ferreira JA, et al. Inflammatory marker trajectories associated with frailty and ageing in a 20-year longitudinal study[J/OL]. Clin Transl Immunology, 2022, 11(2):e1374.
[6]
Jergović M, Thompson HL, Bradshaw CM, et al. IL-6 can singlehandedly drive many features of frailty in mice[J]. Geroscience, 2021, 43(2):539-549.
[7]
Mourtzi N, Georgakis M, Ntanasi E, et al. Genetically downregulated Interleukin-6 signalling is associated with a lower risk of frailty[J]. Age Ageing, 2023, 52(1):afac318[pii].
[8]
Xu T, Xia R, He F, et al. 5-Hydroxymethylfurfural induces mice frailty through cell senescence-associated sarcopenia caused by chronic inflammation[J/OL]. Heliyon, 2023, 9(2):e13217.
[9]
Kochar BD, Cai W, Ananthakrishnan AN. Inflammatory bowel disease patients who respond to treatment with anti-tumor necrosis factor agents demonstrate improvement in pre-treatment frailty[J]. Dig Dis Sci, 2022, 67(2):622-628.
[10]
Cho HC, Huang Y, Hung JT, et al. Puf-A promotes cancer progression by interacting with nucleophosmin in nucleolus[J]. Oncogene, 2022, 41(8):1155-1165.
[11]
Karki R, Sharma BR, Tuladhar S, et al. Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes[J]. Cell, 2021, 184(1):149-168.e17.
[12]
Kane AE, Keller KM, Heinze-milne S, et al. A murine frailty index based on clinical and laboratory measurements:cLinks between frailty and pro-inflammatory cytokines differ in a sex-specific manner[J]. J Gerontol A Biol Sci Med Sci, 2019, 74(3):275-282.
[13]
Edvardsson M, Sund-Levander M, Milberg A, et al. Elevated levels of CRP and IL-8 are related to reduce survival time: 1-year follow-up measurements of different analytes in frail elderly nursing home residents[J]. Scand J Clin Lab Invest, 2019, 79(5):288-292.
[14]
Hammami S, Ghzaiel I, Hammouda S, et al. Evaluation of pro-inflammatory cytokines in frail Tunisian older adults[J/OL]. PLoS One, 2020, 15(11):e0242152.
[15]
Goldberg EL, Dixit VD. Drivers of age-related inflammation and strategies for healthspan extension[J]. Immunol Rev, 2015, 265(1):63-74.
[16]
Palmer J, Pandit V, Zeeshan M, et al. The acute inflammatory response after trauma is heightened by frailty: A prospective evaluation of inflammatory and endocrine system alterations in frailty[J]. J Trauma Acute Care Surg, 2019, 87(1):54-60.
[17]
Juárez-Cedillo T, Vargas-Alarcón G, Martínez-Rodríguez N, et al. Interleukin 10 gene polymorphisms and frailty syndrome in elderly Mexican people: (Sadem study)[J/OL]. Mol Genet Genomic Med, 2019, 7(9):e918.
[18]
Asadi Shahmirzadi A, Edgar D, Liao CY, et al. Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice[J]. Cell Metab, 2020, 32(3):447-456.e6.
[19]
Li CW, Yu K, Shyh-Chang N, et al. Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention[J]. J Cachexia Sarcopenia Muscle, 2019, 10(3):586-600.
[20]
Samson LD, Engelfriet P, Verschuren W, et al. Impaired JAK-STAT pathway signaling in leukocytes of the frail elderly[J]. Immun Ageing, 2022, 19(1):5.
[21]
Dent E, Hoogendijk EO, Moldovan M. Frailty index from routine laboratory measurements correlates with leukocyte telomere length: Letters to the Editor[J]. Geriatr Gerontol Int, 2018, 18(4):654-655.
[22]
Teixeira-Gomes A, Laffon B, Valdiglesias V, et al. Exploring early detection of frailty syndrome in older adults: Evaluation of oxi-immune markers, clinical parameters and modifiable risk factors[J]. Antioxidants (Basel), 2021, 10(12):1975.
[23]
Valdiglesias V, Marcos-Pérez D, Lorenzi M, et al. Immunological alterations in frail older adults: A cross sectional study[J]. Exp Gerontol, 2018, 112:119-126.
[24]
Xu W, Liang Y, Lin Z. Association between neutrophil-lymphocyte ratio and frailty: The chinese longitudinal healthy longevity survey[J]. Front Med (Lausanne), 2021, 8:783077.
[25]
Wilson D, Drew W, Jasper A, et al. Frailty is associated with neutrophil dysfunction which is correctable with phosphoinositol-3-kinase inhibitors[J]. J Gerontol A Biol Sci Med Sci, 2020, 75(12):2320-2325.
[26]
Blacher E, Tsai C, Litichevskiy L, et al. Aging disrupts circadian gene regulation and function in macrophages[J]. Nat Immunol, 2022, 23(2):229-236.
[27]
Kadoguchi T, Shimada K, Miyazaki T, et al. Promotion of oxidative stress is associated with mitochondrial dysfunction and muscle atrophy in aging mice[J]. Geriatr Gerontol Int, 2020, 20(1):78-84.
[28]
Wu IC, Shiesh SC, Kuo PH, et al. High oxidative stress is correlated with frailty in elderly chinese[J]. J Am Geriatr Soc, 2009, 57(9):1666-1671.
[29]
Serviddio G, Romano AD, Greco A, et al. Frailty syndrome is associated with altered circulating redox balance and increased markers of oxidative stress[J]. Int J Immunopathol Pharmacol, 2009, 22(3):819-827.
[30]
Kameda M, Teruya T, Yanagida M, et al. Frailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility[J]. Proc Natl Acad Sci U S A, 2020, 117(17):9483-9489.
[31]
éCT R, Sangali TD, Clausell NO, et al. C-reactive protein and frailty in heart failure[J]. Am J Cardiol, 2022, 166:65-71.
[32]
Sadjapong U, Yodkeeree S, Sungkarat S, et al. Multicomponent exercise program reduces frailty and inflammatory biomarkers and improves physical performance in community-dwelling older adults: A randomized controlled trial[J]. Int J Environ Res Public Health, 2020, 17(11):3760.
[33]
Yang Y, Hao Q, Flaherty JH, et al. Comparison of procalcitonin, a potentially new inflammatory biomarker of frailty, to interleukin-6 and C-reactive protein among older Chinese hospitalized patients[J]. Aging Clin Exp Res, 2018, 30(12):1459-1464.
[34]
Pilotto A, Dini S, Daragjati J, et al. Combined use of the multidimensional prognostic index (MPI) and procalcitonin serum levels in predicting 1-month mortality risk in older patients hospitalized with community-acquired pneumonia (CAP): A prospective study[J]. Aging Clin Exp Res, 2018, 30(2):193-197.
[35]
Lee WJ, Chen LK, Liang CK, et al. Soluble ICAM-1, independent of IL-6, is associated with prevalent frailty in community-dwelling elderly taiwanese people[J/OL]. PLoS One, 2016, 11(6):e0157877.
[36]
Kou L, Yang N, Dong B, et al. Interaction between SELP genetic polymorphisms with inflammatory cytokine interleukin-6 (IL-6) gene variants on cardiovascular disease in Chinese Han population[J]. Mamm Genome, 2017, 28(9-10):436-442.
[37]
Hernández B, Fuentes E, Palomo I, et al. Increased platelet function during frailty[J]. Exp Hematol, 2019, 77:12-25.e2.
[38]
Calder PC. Omega-3 fatty acids and inflammatory processes: from molecules to man[J]. Biochem Soc Trans, 2017, 45(5):1105-1115.
[39]
Angulo J, El Assar M, álvarez-Bustos A, et al. Physical activity and exercise: Strategies to manage frailty[J]. Redox Biol, 2020, 35:101513.
[1] 黄洁, 赵丹, 韩冰, 刘波. 腰椎退行性疾病患者术后早期下地时机及效果的研究进展[J]. 中华损伤与修复杂志(电子版), 2024, 19(02): 168-171.
[2] 陈静, 王晓玲, 安康. 老年进展期胃癌术后腹膜转移的相关因素及治疗进展[J]. 中华普外科手术学杂志(电子版), 2024, 18(02): 225-228.
[3] 李凤仪, 李若凡, 高旭, 张超凡. 目标导向液体干预对老年胃肠道肿瘤患者术后血流动力学、胃肠功能恢复的影响[J]. 中华普外科手术学杂志(电子版), 2024, 18(01): 29-32.
[4] 宋玮, 黄修丽, 李鑫, 史雅琼, 张晔, 邓飞, 高燕. 改良衰弱指数对重症肺部感染的预后分析[J]. 中华肺部疾病杂志(电子版), 2024, 17(01): 119-122.
[5] 张煜彭, 李浩南, 付焱, 冯继伟, 刘凯, 张文凯. 术后房颤对老年髋部骨折患者预后影响的研究进展[J]. 中华老年骨科与康复电子杂志, 2024, 10(01): 51-56.
[6] 汤峥丽, 王芳, 王唯坚. 中老年人群幽门螺杆菌感染对非酒精性脂肪肝及冠状动脉粥样硬化影响的关联性分析[J]. 中华消化病与影像杂志(电子版), 2024, 14(02): 137-140.
[7] 陈润祥, 张大涯, 陈世锔, 张晓冬, 黄士美, 陈晨, 李达, 曾凡, 白飞虎. 281例消化性溃疡出血的临床特征[J]. 中华临床医师杂志(电子版), 2023, 17(11): 1147-1153.
[8] 郭震天, 张宗明, 赵月, 刘立民, 张翀, 刘卓, 齐晖, 田坤. 机器学习算法预测老年急性胆囊炎术后住院时间探索[J]. 中华临床医师杂志(电子版), 2023, 17(09): 955-961.
[9] 孙爱成, 曹月洲, 贾振宇, 赵林波, 施海彬, 刘圣. 低灌注强度比值对老年急性前循环大血管闭塞性脑卒中患者机械取栓治疗预后的影响[J]. 中华介入放射学电子杂志, 2024, 12(01): 15-21.
[10] 葛静萍, 尹媛媛, 李燕. 梯度压力袜联合间歇充气加压在老年新型冠状病毒肺炎患者预防下肢深静脉血栓形成中的应用[J]. 中华介入放射学电子杂志, 2024, 12(01): 70-74.
[11] 李兰, 向华, 莫伟, 胡琴, 李琴, 吴雅琴, 李玉莲, 彭小蓉. 社区老年人静脉血栓栓塞症认知水平的调查研究[J]. 中华介入放射学电子杂志, 2024, 12(01): 75-81.
[12] 解艳红, 陈凌燕, 邵晓露, 沈珊珊, 李方舟, 蓝肖燕. 老年住院患者衰弱风险预测模型研究进展[J]. 中华老年病研究电子杂志, 2024, 11(01): 11-17.
[13] 冯永拿, 叶健. 呼出气一氧化氮在老年哮喘-慢性阻塞性肺疾病重叠诊断中的价值[J]. 中华老年病研究电子杂志, 2024, 11(01): 30-34.
[14] 沈洁, 谢鸿阳, 夏翠俏, 黄勇华. 脑小血管病与认知衰弱的研究现状[J]. 中华脑血管病杂志(电子版), 2024, 18(02): 181-184.
[15] 聂倩倩, 程桂荣, 曾燕, 鄢华. 代谢性心血管疾病共病增加中国社区老年人痴呆风险[J]. 中华脑血管病杂志(电子版), 2024, 18(01): 27-32.
阅读次数
全文


摘要