高尿酸血症是一种常见的代谢性疾病，其病理损伤并不局限于肾脏、关节等部位，可引起一系列全身性炎症反应。研究发现，高尿酸血症可能通过促进炎症反应、诱导氧化应激等促进冠状动脉钙化的发生和发展，且与高血压、糖尿病等冠心病危险因素相互影响，增加冠状动脉钙化的风险。在基因层面，孟德尔随机化研究也为高尿酸血症与冠状动脉疾病存在关联提供了新的证据。本文对高尿酸血症与冠状动脉钙化之间的关系进行综述，旨在厘清高尿酸血症影响冠状动脉钙化的可能机制，为冠状动脉钙化的防治和干预提供新的思路。

Hyperuricemia is a common metabolic disease, whose pathological damage is not limited to kidney, joint and other parts, but can cause a series of systemic inflammatory reactions. Studies have found that hyperuricemia may promote the occurrence and development of coronary artery calcification by promoting inflammatory response and inducing oxidative stress, and interact with coronary heart disease risk factors such as hypertension and diabetes to increase the risk of coronary artery calcification. At the genetic level, mendelian randomization studies have also provided new evidence for the association between hyperuricemia and coronary artery disease. This article reviews the relationship between hyperuricemia and coronary artery calcification, aiming to clarify the possible mechanism of hyperuricemia affecting coronary artery calcification, and provide new ideas for the prevention and treatment of coronary artery calcification.