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中华老年病研究电子杂志 ›› 2022, Vol. 09 ›› Issue (02) : 40 -43. doi: 10.3877/cma.j.issn.2095-8757.2022.02.009

老年消化疾病

艾普拉唑与奥美拉唑治疗老年人消化性溃疡的疗效比较
周义1,(), 李瓒2, 汤国彬1, 李元明1, 韦思琪1   
  1. 1. 628000 四川省广元市中心医院消化内科
    2. 628099 四川省广元市中医医院普通外科
  • 收稿日期:2021-10-21 出版日期:2022-05-28
  • 通信作者: 周义

Efficacy comparison of eprazole and omeprazole in the treatment of peptic ulcer in the elderly

Yi Zhou1,(), Zan Li2, Guobin Tang1, Yuanming Li1, Siqi Wei1   

  1. 1. Department of Gastroenterology, Guangyuan Central Hospital, Guangyuan 628000, China
    2. Department of General Surgery, Guangyuan Hospital of Traditional Chinese Medicine, Guangyuan 628099, China
  • Received:2021-10-21 Published:2022-05-28
  • Corresponding author: Yi Zhou
引用本文:

周义, 李瓒, 汤国彬, 李元明, 韦思琪. 艾普拉唑与奥美拉唑治疗老年人消化性溃疡的疗效比较[J/OL]. 中华老年病研究电子杂志, 2022, 09(02): 40-43.

Yi Zhou, Zan Li, Guobin Tang, Yuanming Li, Siqi Wei. Efficacy comparison of eprazole and omeprazole in the treatment of peptic ulcer in the elderly[J/OL]. Chinese Journal of Geriatrics Research(Electronic Edition), 2022, 09(02): 40-43.

目的

比较艾普拉唑与奥美拉唑治疗老年消化性溃疡的疗效。

方法

选取2020年4月至2021年4月在广元市中心医院确诊的老年消化性溃疡患者78例,其中39例采用奥美拉唑+阿莫西林+呋喃唑酮治疗(对照组),余39例采用艾普拉唑+阿莫西林+呋喃唑酮治疗(观察组),均持续治疗14 d。比较两组患者治疗后的临床疗效、幽门螺旋杆菌(Hp)清除率,以及治疗前后血管生长因子、炎症因子、胃肠动力学水平,并记录不良反应发生情况。计数资料的比较采用χ2检验,计量资料的比较采用t检验。

结果

观察组治疗后的总有效率和Hp清除率均明显高于对照组(χ2=5.186、4.337,P<0.05)。治疗后,与对照组比较,观察组血管内皮生长因子和碱性成纤维细胞生长因子水平升高更加显著(t=5.189、5.306,P<0.01);IL-17、IL-10、一氧化氮水平下降更加显著(t=5.207、3.190、5.643,P<0.01);胃泌素、生长抑素、胃动素水平改善更加显著(t=6.370、4.510、3.195,P<0.01)。两组患者不良反应发生率的差异无统计学意义(χ2=0.557,P>0.05)。

结论

艾普拉唑治疗老年消化性溃疡的疗效优于奥美拉唑,可提高Hp清除率和血管生长因子水平,降低炎症因子水平,改善胃动力,促进损坏黏膜修复。

Objective

To compare the efficacy of eprazole and omeprazole in the treatment of elderly patients with peptic ulcer.

Methods

A total of 78 elderly patients with peptic ulcer diagnosed in Guangyuan Central Hospital during April 2020 and April 2021 were selected. Among them, 39 patients were treated with omeprazole + amoxicillin + furazolidone (control group), and 39 patients were treated with eprazole + amoxicillin + furazolidone (observation group), both treatments lasted for 14 days. The clinical efficacy, clearance rate of Helicobacter pylori (Hp), levels of vascular growth factors, inflammatory factors and gastrointestinal dynamics before and after treatment were compared between the two groups, and adverse reactions were recorded. Chi-square test was used for comparison of counting data groups, t test was used for comparison of measurement data.

Results

The total effective rate and Hp clearance rate of observation group were significantly higher than those of control group (χ2=5.186, 4.337, P < 0.05). After treatment, compared with the control group, the levels of vascular endothelial growth factor and basic fibroblast growth factor in the observation group increased more significantly (t=5.189, 5.306, P < 0.01); the levels of IL-17, IL-10 and nitric oxide in the observation group decreased significantly (t=5.207, 3.190, 5.643, P < 0.01); the levels of gastrin, somatostatin and motilin in the observation group were significantly improved (t=6.370, 4.510, 3.195, P < 0.01). There was no significant difference in the incidence of adverse reactions between the two groups (χ2=0.557, P > 0.05).

Conclusion

The efficacy of eprazole in the treatment of senile peptic ulcer is better than omeprazole, which can improve Hp clearance rate and vascular growth factor level, reduce inflammatory factor level, improve gastric motility and promote damaged mucosa repair.

表1 两组患者治疗前后血管生长因子水平比较(pg/mL,±s
表2 两组患者治疗前后炎症因子水平比较(±s
表3 两组患者治疗前后胃肠动力学相关指标检测结果比较(±s
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