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中华老年病研究电子杂志 ›› 2020, Vol. 07 ›› Issue (03) : 41 -47. doi: 10.3877/cma.j.issn.2095-8757.2020.03.009

所属专题: 文献

综述

睡眠障碍与阿尔茨海默病
胡华1, 吴永华2,()   
  1. 1. 215000 苏州大学附属第二医院神经内科
    2. 215000 南京医科大学附属苏州市立医院老年医学科
  • 收稿日期:2020-04-29 出版日期:2020-08-28
  • 通信作者: 吴永华
  • 基金资助:
    苏州市民生科技医疗卫生应用基础研究(SYSD2019114)

Sleep disorders and Alzheimer's disease

Hua Hu1, Yonghua Wu2,()   

  1. 1. Department of Neurology, the Second Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu Province, China
    2. Department of Geriatrics, Suzhou Municipal Hospital of Nanjing Medical University, Suzhou 215000, Jiangsu Province, China
  • Received:2020-04-29 Published:2020-08-28
  • Corresponding author: Yonghua Wu
  • About author:
    Corresponding author: Wu Yonghua, Email:
引用本文:

胡华, 吴永华. 睡眠障碍与阿尔茨海默病[J/OL]. 中华老年病研究电子杂志, 2020, 07(03): 41-47.

Hua Hu, Yonghua Wu. Sleep disorders and Alzheimer's disease[J/OL]. Chinese Journal of Geriatrics Research(Electronic Edition), 2020, 07(03): 41-47.

随着社会人口老龄化的不断加快以及人均寿命的不断增加,阿尔茨海默病患病率不断增高,而老年人大多会出现不同程度的生理性睡眠改变,甚至发展为各种类型的睡眠障碍。目前,关于阿尔茨海默病的具体机制尚未明确,有关睡眠与阿尔茨海默病的关系也不清楚。本文通过阐述不同类型睡眠障碍与阿尔茨海默病的关系,从与睡眠中枢相关β-淀粉样蛋白病理性沉积学说、神经递质系统失衡假说、昼夜节律紊乱机制等多方面探讨两者的关联机制以及临床现有治疗方案,旨在为阿尔茨海默病睡眠障碍的有效治疗及延缓阿尔兹海默病的进展提供理论依据和参考。

With the accelerating aging of the population and the continuous increase of life expectancy, the prevalence of Alzheimer's disease is constantly increasing, and the elderly will mostly appear different degrees of physiological sleep changes, and even develop into various types of sleep disorders. The exact mechanism of Alzheimer's disease is not yet clear, nor is the relationship between sleep and alzheimer's. This article tries to clarify the relationship between different types of sleep disorders and Alzheimer's disease, and discusses the association mechanism and clinical treatment from various aspects, such as the theory of pathological deposition of beta-amyloid protein associated with the sleep center, the hypothesis of imbalance of neurotransmitter system, and the mechanism of circadian rhythm disorde, so as to provide theoretical basis and reference for the effective treatment of sleep disorder in Alzheimer's disease.

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