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中华老年病研究电子杂志

中华老年病研究电子杂志 ›› 2019, Vol. 06 ›› Issue (04) : 35 -39. doi: 10.3877/cma.j.issn.2095-8757.2019.04.008

所属专题： 文献；

综述

老年消化道肿瘤患者外周血中系统免疫炎症指数的研究进展
黄嘉宝1, 桑玉1, 全小庆1, 张存泰1,†()   
  1. 1. 430030　武汉，华中科技大学同济医学院附属同济医院综合医疗科
  • 收稿日期:2019-08-11 出版日期:2019-11-28
  • 通信作者: 张存泰

Advances in systemic immune-inflammation index in peripheral blood of elder patients with gastrointestinal cancer

Jiabao Huang1, Yu Sang1, Xiaoqing Quan1, Cuntai Zhang1,†()   

  1. 1. Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  • Received:2019-08-11 Published:2019-11-28
  • Corresponding author: Cuntai Zhang
  • About author:
    Corresponding author: Zhang Cuntai, Email:
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黄嘉宝, 桑玉, 全小庆, 张存泰. 老年消化道肿瘤患者外周血中系统免疫炎症指数的研究进展[J]. 中华老年病研究电子杂志, 2019, 06(04): 35-39.

Jiabao Huang, Yu Sang, Xiaoqing Quan, Cuntai Zhang. Advances in systemic immune-inflammation index in peripheral blood of elder patients with gastrointestinal cancer[J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2019, 06(04): 35-39.

随着人口老龄化程度的不断加重，老年人群患癌率日益增加，症状往往较为隐匿，不易及早发现，同时老年人群与年轻人群不同的生物学特征等问题亦增加了预后判断的难度。因此，选择一种简单有力的预后评价指标显得尤为重要。系统免疫炎症指数（systemic immune inflammation index, SII）作为一种全身炎症反应的评价指标，被证实与老年消化系统肿瘤患者的预后相关，可能与肿瘤状态下机体的促肿瘤与抗肿瘤因素之间失去平衡有关，失衡后中性粒细胞和血小板增多、淋巴细胞减少，SII随之增高。另外，SII与其他炎症指标如预后营养指数、白蛋白-胆红素评分、癌抗原19-9等的联合检测，可以增加对肿瘤患者预后的预测效能。此外，SII可获取性高、操作简便易行、价格低廉，易于临床广泛推广。本文就SII与老年消化系统肿瘤的相关性进行综述，旨在为进一步开展SII相关的临床研究提供参考。

关键词: 系统免疫炎症指数, 消化系统肿瘤, 炎症, 预后

With the increasing degree of population aging, cancer rates are increasing among the elderly. The symptoms are often hidden, which is not easy to be detected at an early stage. Besides, different biological characteristics between the elder and the younger people make the prognostic judgment become more challenging. Therefore, it is important to search a simple and powerful prognostic index. The systemic immune inflammation index (SII), as an evaluation index of systemic inflammatory response, has been proved to be related with the prognosis in elder patients with digestive system neoplasm. The mechanism might be out of balance with pro-tumor factors and anti-tumor factors in the body under the state of tumor. After the body got out of balance, neutrophils and platelets increased, lymphocytes reduced, SII elevated. In addition, the joint detection of SII and other biomarkers, such as prognostic nutritional index, albumin-bilirubin score, carbohydrate antigen 19-9, can increase the prognostic efficacy of patients with cancer. SII could be easy obtained, easy and simple to handle, low cost and popularizing in clinical practice easily. This review summarizes the relationship of SII and gastrointestinal cancer in elder patients, wich is aimed at providing a reference for further SII research.

Key words: Systemic immune inflammation index, Gastrointestinal cancer, Inflammation, Prognosis
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