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中华老年病研究电子杂志 ›› 2018, Vol. 05 ›› Issue (03) : 41 -44. doi: 10.3877/cma.j.issn.2095-8757.2018.03.009

所属专题: 文献

综述

低钠血症与跌倒、骨质疏松及骨折的相关性
张宇1, 李新1, 冷晓2, 王林1,()   
  1. 1. 300211 天津医科大学第二医院干部保健医疗部 天津市老年病学研究所
    2. 21224 Baltimore, MD, Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, USA
  • 收稿日期:2018-04-27 出版日期:2018-08-28
  • 通信作者: 王林

The association between hyponatremia, falls, osteoporosis, and fracture

Yu Zhang1, Xin Li1, Xiao Leng2, Lin Wang1,()   

  1. 1. Department of Geriatric, the Second Hospital of Tianjin Medical University, Tianjin 300211, China
    2. Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, USA
  • Received:2018-04-27 Published:2018-08-28
  • Corresponding author: Lin Wang
  • About author:
    Corresponding author: Wang Lin, Email:
引用本文:

张宇, 李新, 冷晓, 王林. 低钠血症与跌倒、骨质疏松及骨折的相关性[J/OL]. 中华老年病研究电子杂志, 2018, 05(03): 41-44.

Yu Zhang, Xin Li, Xiao Leng, Lin Wang. The association between hyponatremia, falls, osteoporosis, and fracture[J/OL]. Chinese Journal of Geriatrics Research(Electronic Edition), 2018, 05(03): 41-44.

低钠血症是临床最常见的电解质紊乱类型,其发生率随年龄的增加而升高。75%~80%的低钠血症为慢性、无症状的轻中度低钠血症,其中仅有13%~20%得到纠正。近年的研究证实,低钠血症与跌倒发作、骨质疏松症以及骨折具有明显的相关性。机体中1/3的Na+储存在骨骼中,Na+平衡失调是否会引起骨骼钠的改变及其负面影响,尚需进一步深入研究。

Hyponatremia is the most common electrolyte disorder encountered in clinical practice, and the incidence of hyponatremia rises with age. 75%~80% of hyponatremia are mild or moderate, of which are chronic and asymptomatic. Only 13~20% get treated. Several studies have demonstrated that the incidence of falls, osteoporosis and fracture is significantly associated with hyponatremia. 1/3 of the Na+ are stored in the bones. Whether Na+ balance disorders can cause changes in bone sodium and adverse consequences need to be studied.

图1 低钠血症对机体组织、器官的影响
图2 低钠血症诱发骨质疏松症及骨折的病理生理基础
图3 低钠血症作用于骨细胞(成骨细胞及破骨细胞)的可能机制
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