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中华老年病研究电子杂志 ›› 2018, Vol. 05 ›› Issue (03) : 24 -27. doi: 10.3877/cma.j.issn.2095-8757.2018.03.005

所属专题: 文献

临床研究

画钟试验和画钟时长在轻度认知功能障碍诊断中的应用
徐珊瑚1, 金煜1, 陈林辉1, 卢兴娇1, 刘小利1,()   
  1. 1. 310012 杭州,浙江医院神经内科
  • 收稿日期:2018-02-12 出版日期:2018-08-28
  • 通信作者: 刘小利
  • 基金资助:
    浙江省科技厅资助项目(2014C33242、2015C33135); 浙江省医药卫生一般研究资助项目(2012KYB001、2014KYA027、2015KYA003)

Application of clock drawing test and its time consume in the diagnosis of mild cognitive impairment

Shanhu Xu1, Yu Jin1, Linhui Chen1, Xingjiao Lu1, Xiaoli Liu1,()   

  1. 1. Department of Neurology, Zhejiang Hospital, Hangzhou 310013, China
  • Received:2018-02-12 Published:2018-08-28
  • Corresponding author: Xiaoli Liu
  • About author:
    Corresponding author: Liu Xiaoli, Email:
引用本文:

徐珊瑚, 金煜, 陈林辉, 卢兴娇, 刘小利. 画钟试验和画钟时长在轻度认知功能障碍诊断中的应用[J/OL]. 中华老年病研究电子杂志, 2018, 05(03): 24-27.

Shanhu Xu, Yu Jin, Linhui Chen, Xingjiao Lu, Xiaoli Liu. Application of clock drawing test and its time consume in the diagnosis of mild cognitive impairment[J/OL]. Chinese Journal of Geriatrics Research(Electronic Edition), 2018, 05(03): 24-27.

目的

探讨画钟试验和画钟时长在轻度认知功能障碍(mild cognitive impairment,MCI)诊断中的应用价值。

方法

选取2015年12月至2016年12月就诊于浙江医院进行认知功能评估调查的104例MCI患者(MCI组)和188例健康老年人(对照组),均行简易神经心理量表(mini-mental state examination,MMSE)和画钟试验评估。比较两组对象画钟试验得分以及各组中得分满分者画钟时长的差异,并分析画钟试验诊断MCI的敏感性和特异性。

结果

两组对象MMSE得分的差异无统计学意义(t=1.907,P>0.05)。MCI组画钟试验得分显著低于对照组(t=3.190,P<0.01)。对照组画钟试验不同得分分布情况明显优于MCI组(z=8.171,P<0.01)。MCI组画钟时长显著长于对照组(t=2.941,P<0.01)。以画钟试验得分≤3分进行MCI诊断的敏感度为38.46%,特异度为76.60%;以得分≤4分进行诊断的敏感度为52.88%,特异度为61.70%。

结论

画钟试验一定程度上有助于鉴别诊断MCI和健康人群,而且MCI患者画钟时长明显长于健康人群。

Objective

To investigate the value of clock drawing test (CDT) and the time consumed in CDT in the diagnosis of mild cognitive impairment (MCI).

Methods

Patients with mild cognitive impairment (MCI group, n=104) and healthy controls (control group, n=188) who were admitted to Zhejiang hospital from December 2015 to December 2016 were selected and underwent neuropsychological examination, including Mini-mental state examination (MMSE) and CDT. The score of CDT and the time consume in correct clock drawing between two groups were compared. The sensitivity and specificity of CDT in diagnosing MCI were also analyzed.

Results

There was no significant difference in MMSE scores in two groups (t=1.907, P>0.05), while the CDT scores of MCI group were significantly lower than that of the control group (t=3.190, P<0.01). The distribution of higher scores in the MCI group was significantly worse than that in control group (z=8.171, P<0.01). The time consumed in MCI group was significantly longer than that in control group (t=2.941, P<0.01). At a cutoff of ≤3, the CDT had a sensitivity of 38.46% and specificity of 76.60%; at a cutoff of ≤4, the CDT had a sensitivity of 52.88% and specificity of 61.70%.

Conclusion

CDT and its time consume are helpful to differentiate MCI from healthy control.

表1 两组患者的一般资料的比较
表2 两组对象MMSE、画钟试验得分及不同画钟试验得分分布情况的比较
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