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中华老年病研究电子杂志 ›› 2017, Vol. 04 ›› Issue (02) : 39 -42. doi: 10.3877/cma.j.issn.2095-8757.02.007

所属专题: 文献

综述

外周血microRNA在阿尔茨海默病诊治中的研究进展
许娟1, 徐静1, 孟冉1, 赵园园1, 郑伟1, 吴玉泉1,()   
  1. 1. 310013 杭州,中国人民解放军第一一七医院干部病房
  • 收稿日期:2017-04-03 出版日期:2017-05-28
  • 通信作者: 吴玉泉
  • 基金资助:
    浙江省自然科学基金资助项目(LY13H250001); 杭州市科技发展计划项目(20130633B31)

Research progress of peripheral blood miRNA in Alzheimer's disease

Juan Xu1, Jing Xu1, Ran Meng1, Yuanyuan Zhao1, Wei Zheng1, Yuquan Wu1,()   

  1. 1. Department of Cadre Ward, the 117th Hospital of PLA, Hangzhou 310013, China
  • Received:2017-04-03 Published:2017-05-28
  • Corresponding author: Yuquan Wu
  • About author:
    Corresponding author: Wu Yuquan, Email:
引用本文:

许娟, 徐静, 孟冉, 赵园园, 郑伟, 吴玉泉. 外周血microRNA在阿尔茨海默病诊治中的研究进展[J/OL]. 中华老年病研究电子杂志, 2017, 04(02): 39-42.

Juan Xu, Jing Xu, Ran Meng, Yuanyuan Zhao, Wei Zheng, Yuquan Wu. Research progress of peripheral blood miRNA in Alzheimer's disease[J/OL]. Chinese Journal of Geriatrics Research(Electronic Edition), 2017, 04(02): 39-42.

目前,阿尔兹海默病(Alzheimer's Disease, AD)的早期诊断尚缺乏有效的方法,可靠、便捷的生物学标志物是临床研究的方向。外周血miRNA表达稳定,检测方法简单易行,可进行批量筛查,是理想的早期筛查手段。本文以血清、外周血单核细胞、全血、血浆等多种来源的miRNA作为研究对象,综述miRNA在AD诊治中的研究进展,以期为AD的诊断提供新思路。

Clinical diagnosis of Alzheimer’s disease (AD) is difficult in early stages. Reliable biomarkers are required for diagnosis of AD. The detection of miRNAs which is stable in peripheral blood is an ideal means of performing early screening because of its convenience, non-invasiveness, and suitability for screening large populations. This paper introduces the miRNAs detection in serum, blood mononuclear cells, whole blood or plasma in Alzheimer's disease, providing a new method for AD diagnosis.

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