[1] |
Salhotra A, Shah HN, Levi B, et al.Mechanisms of bone development and repair[J].Nat Rev Mol Cell Biol, 2020,21(11):696-711.
|
[2] |
Long F.Building strong bones: Molecular regulation of the osteoblast lineage[J].Nat Rev Mol Cell Biol, 2011, 13(1):27-38.
|
[3] |
Novack DV, Teitelbaum SL.The osteoclast: Friend or foe[J]?Annu Rev Pathol, 2008, 3(4):57-84.
|
[4] |
Teitelbaum SL, Ross FP.Genetic regulation of osteoclast development and function[J].Nat Rev Genet, 2003, 4(8):638-649.
|
[5] |
Coleman RE, Croucher PI, Padhani AR, et al.Bone metastases[J].Nat Rev Dis Prim, 2020, 6:1083.
|
[6] |
Zhang H, Wang L, Cui J, et al.Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression[J].Sci Advanc, 2023, 9(14):eabo7868.
|
[7] |
Marini JC, Forlino A, Bächinger HP, et al.Osteogenesis imperfecta[J].Nat Rev Dis Prim, 2017, 3(17):52.
|
[8] |
Ponzetti M, Rucci N.Osteoblast Differentiation and signaling:Established concepts and emerging topics[J].Int J Mol Sci, 2021,22(13):6651.
|
[9] |
Lee WC, Guntur AR, Long F, et al.Energy metabolism of the osteoblast: Implications for osteoporosis[J].Endocr Rev, 2017,38(3):255-266.
|
[10] |
Ruscitto A, Chen P, Tosa I, et al.Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identity[J].Cell Stem Cell, 2023, 30(9):1179-1198.
|
[11] |
Hall AC.The role of chondrocyte morphology and volume in controlling phenotype-implications for osteoarthritis, cartilage repair, and cartilage engineering[J].Curr Rheumatol Rep, 2019,21(8):38.
|
[12] |
Choi WS, Lee G, Song WH, et al.The CH25H-CYP7B1-RORα axis of cholesterol metabolism regulates osteoarthritis[J].Nature,2019, 566(7743):254-258.
|
[13] |
Collins JA, Kim CJ, Coleman A, et al.Cartilage-specific Sirt6 deficiency represses IGF-1 and enhances osteoarthritis severity in mice[J].Annal Rheumat Dis, 2023, 82(11):1464-1473.
|
[14] |
Xu F, Li W, Yang X, et al.The roles of epigenetics regulation in bone metabolism and osteoporosis[J].Front Cell Dev Biology,2020, 8:619301.
|
[15] |
Shen J, Abu-Amer Y, O'keefe RJ, et al.Inflammation and epigenetic regulation in osteoarthritis[J].Connect Tissue Res,2017, 58(1):49-63.
|
[16] |
Deng P, Yuan Q, Cheng Y, et al.Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging[J].Cell Stem Cell, 2021, 28(6):1057-1073.
|
[17] |
Liu H, Zhai L, Liu Y, et al.The histone demethylase KDM5C controls female bone mass by promoting energy metabolism in osteoclasts[J].Sci Adv, 2023, 9(14):eadg0731.
|
[18] |
Assi R, Cherifi C, Cornelis FMF, et al.Inhibition of KDM7A/B histone demethylases restores H3K79 methylation and protects against osteoarthritis[J].Ann Rheum Dis, 2023, 82(7):963-973.
|
[19] |
Krivtsov AV, Evans K, Gadrey JY, et al.A menin-mll inhibitor induces specific chromatin changes and eradicates disease in models of mll-rearranged leukemia[J].Cancer Cell, 2019,36(6):660-673.
|
[20] |
Bitoun E, Oliver PL, Davies KE.The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling[J].Human Mol Genet, 2007, 16(1):92-106.
|
[21] |
Guenther MG, Lawton LN, Rozovskaia T, et al.Aberrant chromatin at genes encoding stem cell regulators in human mixedlineage leukemia [J].Genes Dev, 2008, 22(24):3403-3408.
|
[22] |
Krivtsov AV, Feng Z, Lemieux ME, et al.H3K79 methylation profiles define murine and human MLL-AF4 leukemias[J].Cancer Cell, 2008, 14(5):355-368.
|
[23] |
Milne TA, Martin ME, Brock HW, et al.Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus,promoting transcription and multiple histone modifications[J].Cancer Res, 2005, 65(24):11367-11374.
|
[24] |
Okada Y, Feng Q, Lin Y, et al.hDOT1L links histone methylation to leukemogenesis [J].Cell, 2005, 121(2):167-178.
|
[25] |
Yang M, Yu H, Yu X, et al.Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells[J].Cell Stem Cell, 2022, 29(3):400-418.
|
[26] |
Nil Z, Deshwar AR, Huang Y, et al.Rare de novo gain-of-function missense variants in DOT1L are associated with developmental delay and congenital anomalies[J].Am J Human Genet, 2023,110(11):1919-1937.
|
[27] |
Zhao S, Allis CD, Wang GG.The language of chromatin modification in human cancers[J].Nat Rev Cancer, 2021,21(7):413-430.
|
[28] |
Vatapalli R, Sagar V, Rodriguez Y, et al.Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer[J].Nat Communicat, 2020, 11(1):4153.
|
[29] |
Hou Y, Huang S, Liu J, et al.DOT1L promotes cell proliferation and invasion by epigenetically regulating STAT5B in renal cell carcinoma[J].Am J Cancer Res, 2023, 13(1):276-292.
|
[30] |
Sharma G, Sultana A, Abdullah KM, et al.Epigenetic regulation of bone remodeling and bone metastasis[J].Semin Cell Dev Bio,2024, 154(Pt C):275-285.
|
[31] |
Ghayor C, Weber FE.Epigenetic regulation of bone remodeling and its impacts in osteoporosis[J].Int J Mol Sci, 2016, 17(9):1446.
|
[32] |
Berendsen AD, Olsen BR.Bone development[J].Bone, 2015,80:14-18.
|
[33] |
Long F, Ornitz DM.Development of the endochondral skeleton[J].Cold Spring Harb Perspect Bio, 2013, 5(1):a008334.
|
[34] |
Kronenberg HM.Developmental regulation of the growth plate[J].Nature, 2003, 423(6937):332-336.
|
[35] |
Sutter PA, Karki S, Crawley I, et al.Mesenchyme-specific loss of Dot1L histone methyltransferase leads to skeletal dysplasia phenotype in mice[J].Bone, 2021, 142:115677.
|
[36] |
Jo SY, Domowicz MS, Henry JG, et al.The role of dot1l in prenatal and postnatal murine chondrocytes and trabecular bone[J].JBMR Plus, 2020, 4(2):e10254.
|
[37] |
Yao Q, Wu X, Tao C, et al.Osteoarthritis: Pathogenic signaling pathways and therapeutic targets[J].Signal Transduct Target Ther,2023, 8(1):56.
|
[38] |
Martel-Pelletier J, Barr AJ, Cicuttini FM, et al.Osteoarthritis[J].Nat Rev Dis Prim, 2016, 2:16072.
|
[39] |
Baird DA, Paternoster L, Gregory JS, et al.Investigation of the relationship between susceptibility loci for hip osteoarthritis and dual x-ray absorptiometry-derived hip shape in a population-based cohort of perimenopausal women[J].Arthritis Rheumatol, 2018,70(12):1984-1993.
|
[40] |
He D, Liu J, Hai Y, et al.Increased DOT1L in synovial biopsies of patients with OA and RA[J].Clin Rheumat, 2018, 37(5):1327-1332.
|
[41] |
Monteagudo S, Cornelis FMF, Aznar-Lopez C, et al.DOT1L safeguards cartilage homeostasis and protects against osteoarthritis[J].Nat Communicat, 2017, 8:15889.
|
[42] |
Yang Y, Liu Y, Wang Y, et al.Regulation of SIRT1 and its roles in inflammation [J].Front Immunol, 2022, 13:831168.
|
[43] |
Wang J, Zhang Y, Cao J, et al.The role of autophagy in bone metabolism and clinical significance[J].Autophagy, 2023,19(9):2409-2427.
|
[44] |
Batshon G, Elayyan J, Qiq O, et al.Serum NT/CT SIRT1 ratio reflects early osteoarthritis and chondrosenescence [J].Annal Rheumat Dis, 2020, 79(10):1370-1380.
|
[45] |
Matsuzaki T, Matsushita T, Takayama K, et al.Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice[J].Annal Rheumat Dis, 2014, 73(7):1397-1404.
|
[46] |
De Roover A, Nunez AE, Cornelis FM, et al.Hypoxia induces DOT1L in articular cartilage to protect against osteoarthritis[J/OL].JCI Insight, 2021, 6(24): e150451.
|
[47] |
Lories RJ, Corr M, Lane NE.To Wnt or not to Wnt: The bone and joint health dilemma[J].Nat Rev Rheumatol, 2013, 9(6):328-339.
|
[48] |
Mahmoudi T, Boj SF, Hatzis P, et al.The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis[J].PLoS biology, 2010, 8(11):e1000539.
|
[49] |
Collins FL, Rios-Arce ND, Schepper JD, et al.The potential of probiotics as a therapy for osteoporosis[J].Microbiol Spectr, 2017,5(4): 10.1128/microbiolspec.bad-0015-2016.
|
[50] |
Raisz LG.Pathogenesis of osteoporosis: Concepts, conflicts, and prospects[J].J Clinic Investigat, 2005, 115(12):3318-3325.
|
[51] |
Sirufo MM, De Pietro F, Bassino EM, et al.Osteoporosis in skin diseases[J].Int J Mol Sci, 2020, 21(13):4749.
|
[52] |
Rachner TD, Khosla S, Hofbauer LC.Osteoporosis: Now and the future[J].Lancet, 2011, 377(9773):1276-1287.
|
[53] |
Walker MD, Shane E.Postmenopausal osteoporosis[J].New Engl J Med, 2023, 389(21):1979-1991.
|
[54] |
Gao Y, Ge W.The histone methyltransferase DOT1L inhibits osteoclastogenesis and protects against osteoporosis[J].Cell Death Dis, 2018, 9(2):33.
|
[55] |
Wang C, Chen R, Zhu X, et al.DOT1L decelerates the development of osteoporosis by inhibiting SRSF1 transcriptional activity via microRNA-181-mediated KAT2B inhibition[J].Genomics, 2024, 116(1):110759.
|
[56] |
Yi Y, Ge S.Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemias[J].J Hematol Oncol, 2022,15(1):35.
|
[57] |
Kurani H, Razavipour SF, Harikumar KB, et al.DOT1L is a novel cancer stem cell target for triple-negative breast cancer[J].Cli Cancer Res, 2022, 28(9):1948-1965.
|
[58] |
Ali NM, Niada S, Brini AT, et al.Genomic and transcriptomic characterisation of undifferentiated pleomorphic sarcoma of bone[J].J Pathol, 2019, 247(2):166-176.
|
[59] |
Li YJ, Zhang C, Martincuks A, et al.STAT proteins in cancer:Orchestration of metabolism[J].Nat Rev Cancer, 2023, 23(3):115-34.
|
[60] |
Perakakis N, Farr OM, Mantzoros CS.Leptin in leanness and obesity: JACC state-of-the-art review[J].J Am Coll Cardiol, 2021,77(6):745-760.
|
[61] |
Jeffery EC, Mann TLA, Pool JA, et al.Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair [J].Cell Stem Cell, 2022, 29(11):1547-1561.
|
[62] |
Jurek B, Neumann ID.The oxytocin receptor: From intracellular signaling to behavior[J].Physiol Rev, 2018, 98(3):1805-1908.
|
[63] |
Hanley MR, Benton HP, Lightman SL, et al.A vasopressin-like peptide in the mammalian sympathetic nervous system[J].Nature,1984, 309(5965):258-261.
|
[64] |
Hakanson DO, Bergstrom WH.Phototherapy-induced hypocalcemia in newborn rats: Prevention by melatonin[J].Science, 1981, 214(4522):807-809.
|
[65] |
Zhao Y, Peng X, Wang Q, et al.Crosstalk between the neuroendocrine system and bone homeostasis[J].Endocr Rev,2024, 45(1):95-124.
|
[66] |
Chen H, Hu B, Lv X, et al.Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis[J].Nat Communicat, 2019,10(1):181.
|
[67] |
Babey ME, Krause WC, Chen K, et al.A maternal brain hormone that builds bone[J].Nature, 2024, 632(8024):357-365.
|
[68] |
Franz H, Villarreal A, Heidrich S, et al.DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex[J].Nucleic Acids Res, 2019, 47(1):168-183.
|
[69] |
Gray De Cristoforis A, Ferrari F, Clotman F, et al.Differentiation and localization of interneurons in the developing spinal cord depends on DOT1L expression[J].Mol Brain, 2020, 13(1):85.
|
[70] |
Appiah B, Fullio CL, Ossola C, et al.DOT1L activity affects neural stem cell division mode and reduces differentiation and ASNS expression[J].EMBO Rep, 2023, 24(8):e56233.
|
[71] |
Cui J, Carey J, Reijo Pera RA.Identification of DOT1L inhibitor in a screen for factors that promote dopaminergic neuron survival[J].Front Aging Neurosci, 2022, 14:1026468.
|
[72] |
Ferrari F, Arrigoni L, Franz H, et al.DOT1L-mediated murine neuronal differentiation associates with H3K79me2 accumulation and preserves SOX2-enhancer accessibility[J].Nat Communicat,2020, 11(1):5200.
|
[73] |
Roidl D, Hellbach N, Bovio PP, et al.DOT1L activity promotes proliferation and protects cortical neural stem cells from activation of atf4-ddit3-mediated er stress in vitro[J].Stem cells (Dayton,Ohio), 2016, 34(1):233-245.
|
[74] |
Kronman H, Torres-Berrío A, Sidoli S, et al.Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons[J].Nat Neurosci, 2021, 24(5):667-676.
|