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中华老年病研究电子杂志 ›› 2026, Vol. 13 ›› Issue (03) : 1 -12. doi: 10.3877/cma.j.issn.2095-8757.2026.03.001

标准与共识

全身热疗专家共识
《全身热疗专家共识》编写组   
  1. 1. 310013 杭州,浙江医院
  • 收稿日期:2026-01-23 出版日期:2026-08-28
  • 基金资助:
    国家卫生健康委员会科研基金-浙江省卫生健康重大科技计划项目(WKJ-ZJ-2401)

Expert consensus on whole-body hyperthermia

Expert consensus writing group on whole-body hyperthermia   

  1. 1. 310013 Hanghzou, Zhejiang Hospital
  • Received:2026-01-23 Published:2026-08-28
引用本文:

《全身热疗专家共识》编写组. 全身热疗专家共识[J/OL]. 中华老年病研究电子杂志, 2026, 13(03): 1-12.

Expert consensus writing group on whole-body hyperthermia. Expert consensus on whole-body hyperthermia[J/OL]. Chinese Journal of Geriatrics Research(Electronic Edition), 2026, 13(03): 1-12.

近年来,随着医工学科交叉的深入和控温测温技术的进步,全身热疗的受重视程度不断提高。与局部热疗不同,全身热疗通过升高全身温度,不仅可以使病灶局部受到热应激,还能够全面发挥宿主多部位、多途径免疫应答反应,从而广泛调控机体代谢发挥治疗作用。全身热疗凭借其独特优势,已经成为热疗研究领域的前沿热点。目前,已有较多基础研究和临床研究证实了全身热疗在肿瘤与非肿瘤疾病治疗中的潜力和效果。基于此背景,本专家共识着重归纳了全身热疗的定义与分类、抗肿瘤作用机制、临床实施技术、并发症及处理原则等要点,旨在为全身热疗的临床应用和推广提供指导。

In recent years, with the deepening integration of medicine and engineering and advances in thermometry and temperature-control technologies, whole-body hyperthermia (WBH) has attracted increasing attention. Unlike local hyperthermia, WBH elevates the temperature of the entire body, thereby not only subjecting the lesion site to heat stress but also fully mobilizing the host’s immune responses at multiple sites and through multiple pathways, thus broadly regulating body metabolism to exert therapeutic effects. With its unique advantages, WBH has become a frontier hotspot in hyperthermia research. To date, a growing body of basic and clinical evidence has confirmed the therapeutic potential and efficacy of WBH in the treatment of both oncologic and non-oncologic conditions. Against this background, the expert consensus focuses on summarizing key points including the definition and classification of WBH, its antitumor mechanisms, clinical implementation techniques, complications, and management principles, with the aim of providing guidance for the clinical application and promotion of WBH.

[1]
Zschaeck S, Beck M. Whole-body hyperthermia in oncology: Renaissance in the immunotherapy era?[M]//Vaupel P, ed. Water-filtered infrared A (wIRA) irradiation: From research to clinical settings. Cham: Springer, 2022:107-115.
[2]
Evans SS, Repasky EA, Fisher DT. Fever and the thermal regulation of immunity: The immune system feels the heat[J]. Nat Rev Immunol, 2015, 15(6):335-349.
[3]
陈耀龙,杨克虎,王小钦,等.中国制订/修订临床诊疗指南的指导原则(2022版)[J].中华医学杂志,2022,102(10):697-703.
[4]
Langhorst A, Langhorst J. Integrative medicine, naturopathic and complementary medicine in the treatment of fibromyalgia syndrome: An overview against the background of clinical experiences from routine treatment[J]. Schmerz, 2023, 37(5):319-323.
[5]
Lee SY, Fiorentini G, Szasz AM, et al. Quo vadis oncological hyperthermia (2020)?[J]. Front Oncol, 2020, 10:1690.
[6]
Piazena H, Vaupel P. Hyperhydration of breast and skin cancers: Effects on thermophysical tissue properties in clinical hyperthermia with water-filtered infrared A (wIRA) irradiation-an updated review[J]. Int J Hyperthermia, 2025, 42(1):2519352.
[7]
Kok HP, Cressman ENK, Ceelen W, et al. Heating technology for malignant tumors: A review[J]. Int J Hyperthermia, 2020, 37(1):711-741.
[8]
Wust P, Riess H, Hildebrandt B, et al. Feasibility and analysis of thermal parameters for the whole-body hyperthermia system IRATHERM-2000[J]. Int J Hyperthermia, 2000, 16(4):325-339.
[9]
Müller W, Piazena H, Vaupel P. From sun to therapeutic wIRA[M]//Vaupel P, ed. Water-filtered infrared A (wIRA) irradiation: From research to clinical settings. Cham: Springer, 2022:17-33.
[10]
Piazena H, Müller W, Vaupel P. Physical and photobiological basics of wIRA-hyperthermia[M]//Vaupel P, ed. Water-filtered infrared A (wIRA) irradiation: From research to clinical settings. Cham: Springer, 2022:35-53.
[11]
Atkinson ER. Assessment of current hyperthermia technology[J]. Cancer Res, 1979, 39(6 Pt 2):2313-2324.
[12]
Hand JW. Heating techniques in hyperthermia.Ⅱ.Non-ionizing electromagnetic waves[J]. Br J Radiol, 1981, 54(642):446-459.
[13]
von Ardenne M, Krüger W. Combined whole-body and local hyperthermia for cancer treatment: CMT selectotherm technique[J]. Prog Clin Biol Res, 1982, 107:705-713.
[14]
Hosotani K, Katsumura H, Kabuto M, et al. Effect of whole-body hyperthermia on the development of peritumoral brain oedema[J]. Int J Hyperthermia, 1993, 9(1):25-36.
[15]
Christophi C, Winkworth A, Muralihdaran V, et al. The treatment of malignancy by hyperthermia[J]. Surg Oncol, 1998, 7(1-2):83-90.
[16]
Agishi T, Okumura T, Saikusa H, et al. A compact whole-body hyperthermia system utilizing extracorporeal circulation for anticancer treatment[J]. Gan No Rinsho, 1983, 29(5):420-423.
[17]
Karbach J, Neumann A, Brand K, et al. PhaseⅠ clinical trial of mixed bacterial vaccine (Coley's toxins) in patients with NY-ESO-1 expressing cancers: Immunological effects and clinical activity[J]. Clin Cancer Res, 2012, 18(19):5449-5459.
[18]
Viana P, Hamar P. Targeting the heat shock response induced by modulated electro-hyperthermia (mEHT) in cancer[J]. Biochim Biophys Acta Rev Cancer, 2024, 1879(2):189069.
[19]
Yang Q, Zhang R, Tang P, et al. Ultrasound may suppress tumor growth, inhibit inflammation, and establish tolerogenesis by remodeling innatome via pathways of ROS, immune checkpoints, cytokines, and trained immunity/tolerance[J]. J Immunol Res, 2021, 2021:6664453.
[20]
De Grandis MC, Ascenti V, Lanza C, et al. Locoregional therapies and remodeling of tumor microenvironment in pancreatic cancer[J]. Int J Mol Sci, 2023, 24(16):12681.
[21]
Multhoff G, Repasky EA, Vaupel P. Mild hyperthermia induced by water-filtered infrared A irradiation: A potent strategy to foster immune recognition and anti-tumor immune responses in superficial cancers[M]//Vaupel P, ed. Water-filtered infrared A (wIRA) irradiation: From research to clinical settings. Cham: Springer, 2022:129-139.
[22]
Liu P, Ye M, Wu Y, et al. Hyperthermia combined with immune checkpoint inhibitor therapy: Synergistic sensitization and clinical outcomes[J]. Cancer Med, 2023, 12(3):3201-3221.
[23]
Abreu MM, Chocron AF, Smadja DM. From cold to hot: Mechanisms of hyperthermia in modulating tumor immunology for enhanced immunotherapy[J]. Front Immunol, 2025, 16:1487296.
[24]
Mao W, Li W, Hu X. Tumor hyperthermia research progress and application prospect in tumoroids: A review[J]. Mol Clin Oncol, 2024, 20(4):31.
[25]
Wan Mohd Zawawi WFA, Hibma MH, Salim MI, et al. Hyperthermia by near infrared radiation induced immune cells activation and infiltration in breast tumor[J]. Sci Rep, 2021, 11(1):10278.
[26]
Li T, Hu Z, Song F, et al. Photonic hyperthermia synergizes with immune-activators to augment tumor-localized immunotherapy[J]. Small Methods, 2023, 7(5):e2300116.
[27]
Kwon S, Jung S, Baek SH. Combination therapy of radiation and hyperthermia, focusing on the synergistic anti-cancer effects and research trends[J]. Antioxidants (Basel), 2023, 12(4):924.
[28]
Vaupel P, Piazena H, Notter M, et al. From localized mild hyperthermia to improved tumor oxygenation: Physiological mechanisms critically involved in oncologic thermo-radio-immunotherapy[J]. Cancers (Basel), 2023, 15(5):1394.
[29]
Kawai N, Nagai T, Naiki-Ito A, et al. Combination therapy with radiation and hyperthermia-induced clinical complete response of small cell carcinoma of prostate[J]. IJU Case Rep, 2022, 5(2):113-116.
[30]
Vos LMC, Aronson SL, van Driel WJ, et al. Translational and pharmacological principles of hyperthermic intraperitoneal chemotherapy for ovarian cancer[J]. Best Pract Res Clin Obstet Gynaecol, 2022, 78:86-102.
[31]
Yan B, Liu C, Wang S, et al. Magnetic hyperthermia induces effective and genuine immunogenic tumor cell death with respect to exogenous heating[J]. J Mater Chem B, 2022, 10(28):5364-5374.
[32]
Takeda T, Yamada D, Amano S, et al. Hyperthermia enhances antitumor effects of immune checkpoint inhibitors and immune cell therapy[J]. Gan To Kagaku Ryoho, 2024, 51(10):1053-1055.
[33]
Zöller N, Kippenberger S. Influence of wIRA irradiation on wound healing: Focus on the dermis[M]//Vaupel P, ed. Water-filtered infrared A (wIRA) irradiation: From research to clinical settings. Cham: Springer, 2022:195-202.
[34]
Kuratli J, Leonard CA, Frohns A, et al. Refinement of water-filtered infrared A (wIRA) irradiations of in vitro acute and persistent chlamydial infections[J]. J Photochem Photobiol B, 2022, 234:112533.
[35]
Knobel A, Hanusch K, Auen N, et al. Whole-body hyperthermia in psychiatry[M]//Vaupel P, ed. Water-filtered infrared A (wIRA) irradiation: From research to clinical settings. Cham: Springer, 2022:155-164.
[36]
Bachem A, Reed CI. The penetration of light through human skin[J]. Am J Physiol, 1931, 97(1):86-91.
[37]
Witte E. über die qualitativen und quantitativen unterschiede in den strahlungen von natursonne und therapeutisch genutztem kunstlicht sowie über eine neue lampe zur künstlichen herstellung praktisch sonnengleichen lichtes[J]. Strahlentherapie, 1937, 58:113-124.
[38]
Vaupel P, Stofft E. Wassergefilterte infrarot-a-strahlung im vergleich zu konventioneller infrarotstrahlung oder fango-paraffin-packungen: Temperaturprofile bei lokaler wärmetherapie[M]//Vaupel P, Krüger W, eds. Wärmetherapie mit wassergefilterter infrarot-a-strahlung: Grundlagen und anwendungsmöglichkeiten. 2nd ed. Stuttgart: Hippokrates, 1995:135-147.
[39]
Heckel Medizintechnik GmbH. Heckel-Hyperthermietechnik[EB/OL]. [2026-03-02].

URL    
[40]
Von Ardenne Institut für Angewandte Medizinische Forschung GmbH. Von Ardenne-Hyperthermietechnik[EB/OL]. [2026-03-02].

URL    
[41]
Rowe-Horwege RW. Hyperthermia, systemic[M]//Webster JG, ed. Encyclopedia of medical devices and instrumentation. 2nd ed. New York: John Wiley & Sons, 2006:42-62.
[42]
Brockow T, Wagner A, Franke A, et al. A randomized controlled trial on the effectiveness of mild water-filtered near infrared whole-body hyperthermia as an adjunct to a standard multimodal rehabilitation in the treatment of fibromyalgia[J]. Clin J Pain, 2007, 23(1):67-75.
[43]
Walz J, Hinzmann J, Haase I, et al. Whole body hyperthermia in pain therapy. A controlled trial on patients with fibromyalgia[J]. Schmerz, 2013, 27(1):38-45.
[44]
Romeyke T, Stummer H. Multi-modal pain therapy of fibromyalgia syndrome with integration of systemic whole-body hyperthermia—effects on pain intensity and mental state: A non-randomised controlled study[J]. J Musculoskelet Pain, 2014, 22(4):341-355.
[45]
Schleenbecker HG, Schmidt KL. Zur wirkung einer iterativen milden ganzkörperhyperthermie auf den fibromyalgieschmerz[J]. Phys Med Rehab Kuror, 1998, 8:113-117.
[46]
Ettrich U, Konrad B, Prate K, et al. Mild whole body hyperthermia in combination with inpatient multimodal oriented pain therapy: Evaluation in patients with chronic unspecific lumbar back pain[J]. Orthopäde, 2014, 43(2):165-174.
[47]
Weller E, Ullrich D. Infrarot-a-hyperthermie-anwendung bei patienten mit analgetica-abusus wegen chronischer rückenschmerzen[C]//95. Kongress der Gesellschaft für Physikalische Medizin und Rehabilitation. 1990-10-05.
[48]
Lange U, Müller-Ladner U, Dischereit G. Wirkung iterativer ganzkörperhyperthermie mit wassergefilterter infrarot-a-strahlung bei ankylosierender spondylitis - eine kontrollierte, randomisierte, prospektive studie[J]. Akt Rheumatol, 2017, 42(2):122-128.
[49]
Zauner D, Quehenberger F, Hermann J, et al. Whole body hyperthermia treatment increases interleukin 10 and toll-like receptor 4 expression in patients with ankylosing spondylitis: A pilot study[J]. Int J Hyperthermia, 2014, 30(6):393-401.
[50]
Tarner IH, Müller-Ladner U, Uhlemann C, et al. The effect of mild whole-body hyperthermia on systemic levels of TNF-alpha, IL-1 beta and IL-6 in patients with ankylosing spondylitis[J]. Clin Rheumatol, 2009, 28(4):397-402.
[51]
Stegemann I, Hinzmann J, Haase I, et al. Ganzkörperhyperthermie mit wassergefilterter infrarot-a-strahlung bei patienten mit axialer spondyloarthritis[J]. Orthopädie Unfallchirurgie Praxis, 2013(10):458-463.
[52]
Lange U, Schwab F, Müller-Ladner U, et al. Wirkung iterativer ganzkörperhyperthermie mit wassergefilterter infrarot-a-strahlung bei arthritis psoriatica - eine kontrollierte, randomisierte, prospektive studie[J]. Akt Rheumatol, 2014, 39(5):310-316.
[53]
Mischke M. Wirkungen einer einmaligen bzw. seriellen infrarot-a-hyperthermie bei patienten mit arterieller hypertonie der WHO-StadienⅠandⅡ[D]. Berlin: Humboldt-Universität Zu Berlin, 1991.
[54]
Meffert H, Scherf HP, Meffert B. Milde infrarot-a-hyperthermie: Auswirkungen von serienbestrahlungen mit wassergefilterter infrarotstrahlung auf gesunde und kranke mit arterieller hypertonie bzw. systemischer sklerodermie[J]. Akt Dermatol, 1993, 19:142-148.
[55]
Janssen CW, Lowry CA, Mehl MR, et al. Whole-body hyperthermia for the treatment of major depressive disorder: A randomized clinical trial[J]. JAMA Psychiatry, 2016, 73(8):789-795.
[56]
Naumann J, Grebe J, Kaifel S, et al. Effects of hyperthermic baths on depression, sleep and heart rate variability in patients with depressive disorder: A randomized clinical pilot trial[J]. BMC Complement Altern Med, 2017, 17(1):172.
[57]
Hanusch KU, Janssen CH, Billheimer D, et al. Whole-body hyperthermia for the treatment of major depression: Associations with thermoregulatory cooling[J]. Am J Psychiatry, 2013, 170(7):802-804.
[58]
Kobayashi Y, Ito Y, Ostapenko VV, et al. Fever-range whole-body heat treatment stimulates antigen-specific T-cell responses in humans[J]. Immunol Lett, 2014, 162(1 Pt A):256-261.
[59]
Mace TA, Zhong L, Kokolus KM, et al. Effector CD8+ T cell IFN-γ production and cytotoxicity are enhanced by mild hyperthermia[J]. Int J Hyperthermia, 2012, 28(1):9-18.
[60]
Gaipl U. Immunologische Wirkungsmechanismen der Hyperthermie[C]//22. Jahrestagung der Deutschen Gesellschaft für Radioonkologie. Mannheim, 2016-06-16.
[61]
Weigelin B. Activating serial killers of cancer cells with artificial fever: Hyperthermia as supporting strategy for immunotherapy of cancer[C]//Symposium Modern Hyperthermia. Krakow, 2015-11-14.
[62]
Skitzki JJ, Repasky EA, Evans SS. Hyperthermia as an immunotherapy strategy for cancer[J]. Curr Opin Investig Drugs, 2009, 10(6):550-558.
[63]
Bull JMC, Scott GL, Strebel FR, et al. Fever-range whole-body thermal therapy combined with cisplatin, gemcitabine and daily interferon-α: A description of a phaseⅠ-Ⅱ protocol[J]. Int J Hyperthermia, 2008, 24(8):649-662.
[64]
Zaltenbach G. Erfahrungen bei asthma bronchiale und anderen atemwegserkrankungen mit sauerstoff-mehrschritt-therapie und hyperthermie[J]. Erfahrungsheilkunde, 1988, 37(2):79-82.
[65]
Brockow T, Beck I, Müller H, et al. Applicability and effectiveness of mild infrared whole-body hyperthermia in symptomatic osteoarthritis: A pilot study[C]//9th Annual Symposium on Complementary Health Care. Exeter, 2002-12-04—2002-12-06.
[66]
Förster J, Fleischanderl S, Wittstock S, et al. Infrared-mediated hyperthermia is effective in the treatment of scleroderma-associated Raynaud's phenomenon[J]. J Invest Dermatol, 2005, 125(6):1313-1316.
[67]
Förster J, Storch A, Fleischanderl S, et al. Neutrophil respiratory burst is decreased in scleroderma and normalized by near-infrared mediated hyperthermia[J]. Clin Exp Dermatol, 2006, 31(6):799-806.
[68]
Sachse C. Studie der Charité Berlin: Ganzkörperhyperthermie bei Reizdarmsyndrom[C]//Ⅶ. Hyperthermie-Kongress der Deutschen Gesellschaft für Hyperthermie. Berlin, 2016:11.
[69]
Liu P, Wu J, Chen L, et al. Water-filtered infrared a radiation hyperthermia combined with immunotherapy for advanced gastrointestinal tumours[J]. Cancer Med, 2024, 13(14):e70024.
[70]
Wey S. Mammakarzinom-komplementäre Praxis[J]. EHK, 2017, 66:302-314.
[71]
Heckel M, Heckel I. Beobachtungen an 479 infrarothyperthermiebehandlungen - beitrag zur methode der ganzkörperüberwärmung[J]. Med Welt, 1979, 30:971-975.
[72]
Kokura S, Yoshida N, Okuda T, et al. Hyperthermia ameliorates 2,4,6-trinitrobenzene sulphonic acid-induced colitis in rats: The role of heat shock proteins[J]. Int J Hyperthermia, 2007, 23(1):17-28.
[73]
Zais ODA. Hyperthermie und borreliose-verschiedene therapiestrategien[C]//Ⅷ. Hyperthermie-Symposium der Deutschen Gesellschaft für Hyperthermie. Berlin, 2017:6.
[74]
Klemm P, Schulz N, Boettger P, et al. Heat therapy in rheumatic and musculoskeletal diseases-an overview of clinical and molecular effects[J]. Int J Hyperthermia, 2024, 41(1):2322667.
[75]
Dancsak T, Figueroa G, Ottosen M, et al. Management of conscious sedation for patients undergoing fever-range whole-body thermal therapy for advanced and metastatic malignancies[C]//International Congress of Hyperthermic Oncology (ICHO). 2008-04-09—2008-04-12.
[76]
Scott GL, Bull JMC, Koch SM. Management of conscious sedation for the comfort and control of physiological/hemodynamic factors of patients with advanced and/or metastatic malignancies undergoing fever-range whole-body hyperthermia thermo-chemo-bio-therapy[C]//9th International Congress on Hyperthermic Oncology. St. Louis, 2004:89.
[77]
Kraybill WG, Olenki T, Evans SS, et al. A phase I study of fever-range whole-body hyperthermia in patients with advanced solid tumours: Correlation with mouse models[J]. Int J Hyperthermia, 2002, 18(3):253-266.
[78]
Robins HI, Cohen JD, Schmitt CL, et al. Phase I clinical trial of carboplatin and 41.8 °C whole-body hyperthermia in cancer patients[J]. J Clin Oncol, 1993, 11(9):1787-1794.
[79]
Kerner T, Deja M, Ahlers O, et al. Whole-body hyperthermia: A secure procedure for patients with various malignancies?[J]. Intensive Care Med, 1999, 25(9):959-965.
[80]
Heckel-Reusser S. Whole-body hyperthermia (WBH): Historical aspects, current use, and future perspectives[M]//Vaupel P, ed. Water-filtered infrared A (wIRA) irradiation: From research to clinical settings. Cham: Springer, 2022:143-154.
[81]
Hegewisch-Becker S, Gruber Y, Corovic A, et al. Whole-body hyperthermia (41.8 °C) combined with bimonthly oxaliplatin, high-dose leucovorin and 5-fluorouracil 48-hour continuous infusion in pretreated metastatic colorectal cancer: A phaseⅡ study[J]. Ann Oncol, 2002, 13(8):1197-1204.
[82]
Hildebrandt B, Dräger J, Kerner T, et al. Whole-body hyperthermia in the scope of von Ardenne's systemic cancer multistep therapy (sCMT) combined with chemotherapy in patients with metastatic colorectal cancer: A phaseⅠ/Ⅱ study[J]. Int J Hyperthermia, 2004, 20(3):317-333.
[83]
Bakshandeh-Bath A, Stoltz AS, Homann N, et al. Preclinical and clinical aspects of carboplatin and gemcitabine combined with whole-body hyperthermia for pancreatic adenocarcinoma[J]. Anticancer Res, 2009, 29(8):3069-3077.
[84]
Atmaca A, Al-Batran SE, Neumann A, et al. Whole-body hyperthermia in combination with carboplatin in patients with recurrent ovarian cancer: A phaseⅡ study[J]. Gynecol Oncol, 2009, 112(2):384-388.
[85]
Deja M, Ahlers O, Macguill M, et al. Changes in hepatic blood flow during whole-body hyperthermia[J]. Int J Hyperthermia, 2010, 26(2):95-100.
[86]
Ismail-Zade RS, Zhavrid EA, Aleinikova OV, et al. Use of LAK cells and systemic chemotherapy with hyperthermia in the management of chemoresistant tumors[J]. Vopr Onkol, 2010, 56(6):681-686.
[87]
Zhao C, Dai C, Chen X. Whole-body hyperthermia combined with hyperthermic intraperitoneal chemotherapy for the treatment of stage Ⅳ advanced gastric cancer[J]. Int J Hyperthermia, 2012, 28(8):735-741.
[88]
Herzog A. Extreme Ganzkörperhyperthermie bei patientinnen mit metastasiertem mammakarzinom[C]//Ⅶ. Hyperthermie-Symposium der Deutschen Gesellschaft für Hyperthermie. Berlin, 2016:14.
[89]
Herzog A. Prolonged survival times in patients with advanced or metastatic pancreatic cancer after chemotherapy in combination with hyperthermia[C]//International Congress of Hyperthermic Oncology (ICHO). 2016-04-11—2016-04-15.
[90]
Hildebrandt B, Hegewisch-Becker S, Kerner T, et al. Current status of radiant whole-body hyperthermia at temperatures > 41.5 ℃ and practical guidelines for the treatment of adults: The German Interdisciplinary Working Group on Hyperthermia[J]. Int J Hyperthermia, 2005, 21(2):169-183.
[91]
Steinhausen D, Meyer WK, von Ardenne M. Evaluation of systemic tolerance of 42.0 ℃ infrared-A whole-body hyperthermia in combination with hyperglycemia and hyperoxemia: A phase Ⅰ study[J]. Strahlenther Onkol, 1994, 170(6):322-334.
[92]
Krasny SA, Mavrichev AS, Zhavrid EA, et al. Combined treatment of renal cancer invading renal vein or vena cava interior[J]. Exp Oncol, 1995, 17:318-322.
[93]
Takeuchi T, Takeuchi A, Yokoyama M. Clinical experiences of far-infrared whole-body hyperthermia by the use of RHD 2002[C]//Proceedings of the 7th International Congress on Hyperthermic Oncology. Rome, 1996, 2:272-274.
[94]
von Ardenne M. Systemische krebs-mehrschritt-therapie: hyperthermie und hyperglykämie als therapiebasis[M]. Stuttgart: Hippokrates Verlag, 1997:186.
[95]
Bremer K, Meyer A, Lohmann R. Pilot study of whole-body hyperthermia combined with chemotherapy in patients with metastasized pretreated progressive breast, ovarian and colorectal carcinomas[J]. Tumordiagn Ther, 2001, 22:115-120.
[96]
Wehner H, von Ardenne A, Kaltofen S. Whole-body hyperthermia with water-filtered infrared radiation: Technical-physical aspects and clinical experiences[J]. Int J Hyperthermia, 2001, 17(1):19-30.
[97]
von Ardenne A, Wehner H. Extreme whole-body hyperthermia with water-filtered infrared radiation[M]//Baronzio GF, Hager ED, eds. Hyperthermia in cancer treatment: A primer. Boston: Springer, 2006:237-246.
[98]
Robins HI, Dennis WH, Neville AJ, et al. A nontoxic system for 41.8℃ whole-body hyperthermia: Results of a phaseⅠstudy using a radiant heat device[J]. Cancer Res, 1985, 45(8):3937-3944.
[99]
Douwes F. Komplextherapie der chronischen borreliose (lyme disease)-ein neuer therapieansatz: Die Antibiotika augmentierte Thermoeradikation (AAT)[J]. OM Ernährung, 2018(164):F10-F15.
[100]
Deutsche Gesellschaft für Hyperthermie. Leitlinie zur Ganzkörperhyperthermie: Version 1.0[J]. Forum Hyperthermie, 2018(1):5-24.
[101]
Gaworek J, Mayer CT. Tödliche hitze für tumorzellen[J]. Pflegezeitschrift, 2003(1):15-18.
[102]
Reichel M, Scheeren T, Douwes O, et al. Tiefe intravenöse analgosedierung zur extremen ganzkörperhyperthermie in kombination mit chemotherapie[J]. Forum Komplementäre Onkologie (Die Naturheilkunde), 2004(3):4-8.
[103]
Gaworek J, Douwes F. Tödliche hitze für tumorzellen-extreme ganzkörperhyperthermie in der onkologie[J]. Forum Komplementäre Onkologie (Die Naturheilkunde), 2004(5):5-7.
[104]
Jia D, Liu J. Current devices for high-performance whole-body hyperthermia therapy[J]. Expert Rev Med Devices, 2010, 7(3):407-423.
[105]
Hohneck AL, Schmitz-Solheid V, Gencer D, et al. Predictors of successful whole-body hyperthermia in cancer patients: Target temperature achievement and safety analysis[J]. Cancers (Basel), 2025, 17(16):2716.
[106]
Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)[J]. Eur J Cancer, 2009, 45(2):228-247.
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