探讨多基因位点检测对老年非小细胞肺癌（non-small cell lung cancer, NSCLC）患者化疗药物应用的指导价值。

选取2016年5月至2018年5月浙江医院收治的84例老年NSCLC患者，平均分为对照组和观察组。对照组给予常规化疗方案；观察组先行相关基因（包括ERCC1、ABCB1、CYP2D6、GSTP1、MTHFR、NUDT15、UGT1A1、XPC）检测，然后根据基因检测结果制定化疗方案。3周为1个化疗周期，共治疗2个周期。治疗后比较两组患者的近期疗效、不良反应以及相关肿瘤标志物水平。组间计量资料的比较采用t检验，计数资料的比较采用χ²检验。

治疗后，观察组客观有效率为47.62%，对照组为26.19%，差异有统计学意义（χ²=4.140，P<0.05）；观察组疾病控制率为83.33%，对照组为73.81%，差异无统计学意义（χ²=1.130，P>0.05）。治疗前，两组患者各项指标的差异均无统计学意义（P>0.05）；治疗后，两组患者癌胚抗原及糖抗原125的差异均有统计学意义（t=9.852、17.837，P<0.05）。两组患者不良反应中胃肠道反应、白细胞下降、贫血的发生差异均有统计学意义（χ²=3.880、4.200、7.110，P<0.05）。

采用多基因位点检测指导老年NSCLC患者化疗药物的应用，不仅针对性强，还能改善近期疗效、减少不良反应的发生。

To explore the guiding value of multi-geneloci detection for chemotherapy in elderly patients with non-small cell lung cancer (NSCLC).

84 elderly patients with NSCLC admitted to Zhejiang Hospital from May 2016 to May 2018 were divided into control group and observation group on average. The control group was given conventional chemotherapy directly, the observation group detected the relevant genes (including ERCC1, ABCB1, CYP2D6, GSTP1, MTHFR, nudt15, UGT1A1 and XPC), and then formulated the chemotherapy scheme according to the gene detection results. Three weeks was one chemotherapy cycle, with a total of two cycles. After treatment, the short-term efficacy, adverse reactions and related tumor markers were compared between the two groups. T test was used to compare the measurement data between groups, and χ² test was used for comparison of enumeration data.

After treatment, the objective effective rate was 47.62% in the observation group and 26.19% in the control group, the difference was statistically significant (χ²=4.140, P < 0.05); the disease control rate was 83.33% in the observation group and 73.81% in the control group, the difference was not statistically significant(χ²=1.130, P > 0.05). Before treatment, there was no significant difference in all indexes between the two groups (P > 0.05); After treatment, there were significant differences in CEA and CA125 between the two groups (t=9.852, 17.837, P < 0.05). There were significant differences in the occurrence of gastrointestinal reactions, leukopenia and anemia between 2 groups (χ²=3.880, 4.200, 7.110, P < 0.05).

Using multi-geneloci detection to guide the application of chemotherapeutic drugs in elderly patients with NSCLC is not only highly targeted, but also can improve the short-term curative effect and reduce the occurrence of adverse reactions.