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中华老年病研究电子杂志 ›› 2021, Vol. 08 ›› Issue (01) : 41 -44. doi: 10.3877/cma.j.issn.2095-8757.2021.01.010

所属专题: 文献

综述

胆汁酸与高血压的关系
卢丹1, 方宁远2, 汪海娅2,()   
  1. 1. 430060 武汉市第三医院全科医学科
    2. 200127 上海交通大学医学院附属仁济医院老年科
  • 收稿日期:2020-04-28 出版日期:2021-02-28
  • 通信作者: 汪海娅

The relationship between bile acid and hypertension

Dan Lu1, Ningyuan Fang2, Haiya Wang2,()   

  1. 1. Department of General Practice, Wuhan Third Hospital, Wuhan 430060, China
    2. Department of Geriatrics, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
  • Received:2020-04-28 Published:2021-02-28
  • Corresponding author: Haiya Wang
引用本文:

卢丹, 方宁远, 汪海娅. 胆汁酸与高血压的关系[J/OL]. 中华老年病研究电子杂志, 2021, 08(01): 41-44.

Dan Lu, Ningyuan Fang, Haiya Wang. The relationship between bile acid and hypertension[J/OL]. Chinese Journal of Geriatrics Research(Electronic Edition), 2021, 08(01): 41-44.

高血压是最常见的慢性病,也是心血管病最主要的危险因素。目前,关于原发性高血压的病因和发病机制尚未完全阐明,进一步深入探索其相关因素,对于心血管疾病的预防和治疗有着重大的临床意义。胆汁酸是核受体法尼醇X受体的内源性激动剂,同时也是11β羟化固醇脱氢酶的内源性抑制剂,可能参与了原发性高血压等心血管疾病的发生和进展。本文现对胆汁酸与高血压等心血管疾病的关系进行综述,以期为临床提供参考。

Hypertension is the most common chronic disease and the main risk factor of cardiovascular disease. At present, the etiology and pathogenesis of essential hypertension has not been fully elucidated. Further exploration of its related factors has great clinical significance for the prevention and treatment of cardiovascular disease. Bile acids are endogenous agonists of farnesol X receptor and endogenous inhibitors of 11 β - hydroxysteroid dehydrogenase, which may be involved in the occurrence and progress of cardiovascular diseases such as essential hypertension. This article reviews the relationship between bile acids and cardiovascular diseases such as hypertension, in order to provide reference for clinical practice.

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