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中华老年病研究电子杂志

中华老年病研究电子杂志 ›› 2020, Vol. 07 ›› Issue (02) : 32 -35. doi: 10.3877/cma.j.issn.2095-8757.2020.02.008

所属专题： 文献；

临床研究

环状RNA在老年慢性阻塞性肺疾病患者血清中的表达及意义
陈福涛1, 钟富宽1,†(), 白巧红1, 卞光荣1, 杨飏1, 朱江1   
  1. 1. 222000　江苏省连云港市第二人民医院呼吸科
  • 收稿日期:2019-05-24 出版日期:2020-05-28
  • 通信作者: 钟富宽
  • 基金资助:
    连云港市卫生科研项目(201718)

Expression and significance of circular RNA in serum of elderly patients with chronic obstructive pulmonary disease

Futao Chen1, Fukuan Zhong1,†(), Qiaohong Bai1, Guangrong Bian1, Ju Yang1, Jiang Zhu1   

  1. 1. Department of Respiration, the Second Hospital of Lianyungang, Lianyungang 222000, China
  • Received:2019-05-24 Published:2020-05-28
  • Corresponding author: Fukuan Zhong
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引用本文：

陈福涛, 钟富宽, 白巧红, 卞光荣, 杨飏, 朱江. 环状RNA在老年慢性阻塞性肺疾病患者血清中的表达及意义[J]. 中华老年病研究电子杂志, 2020, 07(02): 32-35.

Futao Chen, Fukuan Zhong, Qiaohong Bai, Guangrong Bian, Ju Yang, Jiang Zhu. Expression and significance of circular RNA in serum of elderly patients with chronic obstructive pulmonary disease[J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2020, 07(02): 32-35.

目的

探讨环状RNA（circular ribonucleic acid, circRNA）在老年慢性阻塞性肺疾病（chronic obstructive pulmonary disease, COPD）患者血清中的表达及临床意义。

方法

选择连云港市第二人民医院2014年1月至2016年12月收治的老年COPD患者80例（观察组），另择同期健康体检人群30例作为对照组。检测比较两组对象血清circRNA-001988、circRNA-0000344和circRNA-0000284的表达情况。组间比较采用t检验。

结果

观察组患者血清circRNA-001988、circRNA-0000344和circRNA-0000284的表达均异常，其中circRNA-001988、circRNA-0000344较对照组分别下调了（6.54±2.75）、（5.94±2.89）倍，circRNA-0000284较对照组上调了（8.54±3.25）倍，差异均有统计学意义（t=3.176、2.659、4.535，P<0.05）。

结论

血清环状RNA水平检测可作为COPD诊断和预后的生物标志物，具有一定的临床预测价值。

关键词: 环状RNA, 慢性阻塞性肺病, 诊断, 预测
Objective

To investigate the expression and clinical significance of circular RNA (circRNA) in serum of elderly patients with chronic obstructive pulmonary disease (COPD).

Methods

80 elderly patients with COPD admitted to Lianyungang second people's Hospital from January 2014 to December 2016 were selected (observation group), and 30 healthy people were selected as the control group at the same time. The expression of serum circRNA-001988, circRNA-0000344 and circRNA-0000284 were detected and compared between the two groups. T test was used for comparison between two groups.

Results

The expressions of serum circrNA-001988, CIRcrNa-0000344 and circrNa-0000284 were all abnormal in the observation group. Compared with the control group, the expressions of circrna-001988 and circrna-0000344 in the observation group were decreased by (6.54±2.75) and (5.94±2.89) times respectively (t=3.176, 2.659, P < 0.05), and the expression of circrna-0000284 was (8.54±3.25) times higher than that of the control group (t=4.535, P < 0.05).

Conclusion

Serum circRNA level can be used as a biomarker for diagnosis and prognosis of COPD, and it has clinical predictive value.

Key words: circRNA, Chronic obstructive pulmonary disease, Diagnosis, Predictive
图1 两组对象circRNA-001988表达水平的比较
图2 两组对象circRNA-0000344表达水平的比较
图3 两组对象circRNA-0000284表达水平的比较
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