探讨老年肺癌患者的营养状况和炎症水平及其相关性。

选择2016年10月至2019年3月运城市中心医院收治的肺癌患者120例（观察组）及同期健康体检者120例（对照组）。采用主观整体营养评定量表（PG-SGA）进行营养评定，分为A（0～3分）、B（4～8分）、C（≥9分）三级，同时利用ELASA法测定血清炎性指标[包括白介素1（interleukin-1，IL-1）、肿瘤坏死因子α（tumor necrosis factor α, TNF-α）]。比较两组对象营养状况和炎症水平，分析其相关性。组间比较采用独立样本t检验，计数资料的比较采用χ²检验。

观察组营养不良患者占85.7%，对照组营养不良患者占55.0%，差异有统计学意义（χ²=32.163，P<0.05）。观察组IL-1、TNF-α水平均显著高于对照组（t=6.052、4.479，均P<0.01）。不同营养分级肺癌患者IL-1水平的差异无统计学意义（F=0.143，P>0.05）、TNF-α水平的差异有统计学意义（F=50.005，P<0.01）。营养良好的肺癌患者IL-1、TNF-α水平均显著低于中度和重度营养不良者（t=-5.068、-9.686，均P<0.01），中度营养不良肺癌患者TNF-α水平显著低于重度营养不良者（t=-5.584，P<0.01）。

老年肺癌患者普遍存在营养不良和慢性低度炎症情况，营养不良与慢性低度炎症可能呈相互促进作用。

To explore nutritional status, inflammatory level and their correlation in elderly patients with lung cancer.

120 patients with lung cancer (observation group) and 120 healthy people (control group) admitted to Yuncheng Central Hospital from October 2016 to March 2019 were selected. The subjective overall nutrition assessment scale (PG-SGA) was used for nutrition assessment, which was divided into class A (0 to 3 points), class B (4 to 8 points), and class C (≥9 points). At the same time, the serum inflammatory indicators [including interleukin-1 (IL-1), tumor necrosis factor α (TNF-α)] were measured by ELASA method. The nutritional status and inflammation levels of the two groups were compared, and their correlation was analyzed. The comparison between groups was performed using independent sample t test, and the comparison of count data was performed using chi-square test.

The malnutrition patients in the observation group accounted for 85.7%, and the malnutrition patients in the control group accounted for 55.0%, the difference was statistically significant (χ²=32.163, P < 0.05). The levels of IL-1 and TNF-α in the observation group were significantly higher than those in the control group (t=6.052, 4.479, P < 0.01). There was no significant difference in IL-1 levels between patients with different nutritional grades of lung cancer (F=0.143, P > 0.05), and the difference in TNF-α levels was statistically significant (F=50.005, P < 0.01). The levels of IL-1 and TNF-α in well-nourished patients with lung cancer were significantly lower than those with moderate and severe malnutrition (t=-5.068, -9.686, all P < 0.01), and the levels of TNF-α in patients with moderately malnourished lung cancer were significantly lower than those with severe malnutrition (t=-5.584, P < 0.01).

Malnutrition and chronic low-grade inflammation are common in elderly patients with lung cancer. Malnutrition and chronic low-grade inflammation may promote each other.