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中华老年病研究电子杂志 ›› 2018, Vol. 05 ›› Issue (04) : 4 -10. doi: 10.3877/cma.j.issn.2095-8757.2018.04.002

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帕金森病的昼夜节律异常
郭诗奕1, 王涛1,()   
  1. 1. 430022 武汉,华中科技大学医学院附属协和医院神经内科
  • 收稿日期:2018-05-04 出版日期:2018-11-28
  • 通信作者: 王涛

Abnormal circadian rhythm in Parkinson's disease

Shiyi Guo1, Tao Wang1()   

  • Received:2018-05-04 Published:2018-11-28
  • Corresponding author: Tao Wang
引用本文:

郭诗奕, 王涛. 帕金森病的昼夜节律异常[J]. 中华老年病研究电子杂志, 2018, 05(04): 4-10.

Shiyi Guo, Tao Wang. Abnormal circadian rhythm in Parkinson's disease[J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2018, 05(04): 4-10.

图1 睡眠和昼夜节律生理调节机制(SCN:视交叉上核;DMH:下丘脑背内侧核;hypocretin neurons:下视丘分泌素神经;VLPO:下丘脑前区的腹外侧视前区;LC:蓝斑核;NE:去甲肾上腺素;Galanin:甘丙肽;GABA:γ氨基丁酸;Sleep:睡眠;Wake:觉醒)
图2 褪黑素能系统作用机制(Darkness:黑暗;Retina:视网膜;SCN:视交叉上核;Polysynaptic pathway:多突触通路;NE:去甲肾上腺素;ATP:三磷酸腺苷;Pineal gland:松果体;β receptor:β受体;AANAT:乙酰基转移酶;Chaperone:伴侣分子;Serotonin:血清素;N-acetylserotonin:N-乙酰半胱氨酸;Melatonin:褪黑素)
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