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中华老年病研究电子杂志 ›› 2017, Vol. 04 ›› Issue (04) : 22 -27. doi: 10.3877/cma.j.issn.2095-8757.2017.04.005

所属专题: 文献

综述

非甾体类抗炎药致老年人胃肠道不良反应研究进展
陈金1, 姚健凤1,()   
  1. 1. 200040 上海,复旦大学附属华东医院消化内科
  • 收稿日期:2017-10-20 出版日期:2017-11-28
  • 通信作者: 姚健凤

Research progress of non-steroidal anti-inflammatory drugs on the gastrointestinal tract of the elderly

Jin Chen1, Jianfeng Yao1,()   

  1. 1. Department of Gastroenterology, Huadong Hospital, Fudan University, Shanghai 200040, China
  • Received:2017-10-20 Published:2017-11-28
  • Corresponding author: Jianfeng Yao
  • About author:
    Corresponding author: Yao Jianfeng, Email:
引用本文:

陈金, 姚健凤. 非甾体类抗炎药致老年人胃肠道不良反应研究进展[J]. 中华老年病研究电子杂志, 2017, 04(04): 22-27.

Jin Chen, Jianfeng Yao. Research progress of non-steroidal anti-inflammatory drugs on the gastrointestinal tract of the elderly[J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2017, 04(04): 22-27.

非甾体类抗炎药(nonsteroidal antiinflammatory drugs, NSAIDs)具有良好的抗炎、退热、镇痛等作用,因其应用方便,效果明显,目前在全世界范围内得到广泛应用,尤其在老年人群中的应用更为广泛。但NSAIDs使用过程中产生的不良反应不容忽视,仍应引起临床重视。本文总结近十年来与NSAIDs相关的文献,对NSAIDs的产生过程、运用情况、分类方法、作用机制及不良反应致病机制等方面进行简要介绍,重点综述NSAIDs所致胃肠道不良反应的临床特点及防治策略,旨在提高临床对NASIDs的认识,并为进一步的研究提供线索及方向。

NSAIDs are widely used clinically, especially in old patients because of their excellent effects on anti-inflammation, defervescence, analgesia and so on. However, the side-effects of NSAIDs cannot be ignored. In this paper, we reviewed the literatures on NSAIDs in the past ten years, and made a brief introduction NSAIDs background, classification, mechanisms of both the effects and the side-effects. We also summarized the clinical characteristics of gastrointestinal adverse reactions caused by NSAIDs and the ways how to prevent the side-effects in the elderly.

表1 NSAIDs根据化学结构分类及对应代表药物
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